1.Bilateral idiopathic optic perineuritis in a young Malay woman: A case report
Ayesha Mohd Zain ; Umi Kalthum Md Noh ; Mushawiahti Mustapha ; Norshamsiah Md. Din ; Mae Lynn Catherine Bastion
Neurology Asia 2015;20(4):407-409
A 28-year-old Malay woman presented with severe loss of vision in both eyes associated with periocular
pain on eye movement. She was completely blind at presentation and examination showed optic discs
swelling. Optic nerve imaging showed ‘doughnut sign’, characteristic of optic perineuritis. Steroid was
given over six months. Visual function improved gradually and was maintained at one year follow-up.
This case highlights the importance of differentiation between optic neuritis and optic perineuritis as
visual recovery depends on prolonged management with corticosteroid in optic perineuritis.
Optic Neuritis
2.Unilateral Optic Neuritis after Acute Hepatitis A.
Jeong Bin BONG ; Hyun Goo KANG ; Dae Soo SHIN ; Hyung Suk HAN
Korean Journal of Clinical Neurophysiology 2016;18(1):28-30
No abstract available.
Hepatitis A*
;
Hepatitis*
;
Optic Neuritis*
3.Possible Tuberculous Meningitis Complicated with Optic Neuritis.
Joonwon LEE ; Hyung Chan KIM ; Soo Young BAE ; Dongah LEE ; Kang Min PARK
Journal of the Korean Neurological Association 2016;34(3):253-255
No abstract available.
Optic Neuritis*
;
Tuberculosis, Meningeal*
4.Sinusitis after optico retrobulbar neuritis
Journal of Vietnamese Medicine 2001;263(9):18-27
The study included 63 cases decreased vision caused by optico- retrobulbar neuritis (ORN) and subsequently treated sinustis in the Institute of ORL during 2 years 1991- 1992, leading to the conclusion: Further studies must be carried out to definite the relationship between sinusitis and decreased vision caused by ORN
Sinusitis
;
Optic Neuritis
5.Questioning the Diagnosis of Recurrent Optic Neuritis Associated with Neuro-Behçet's Disease.
Soo Young BAE ; Yong Wan KIM ; Kyong Jin SHIN
Journal of Clinical Neurology 2018;14(2):242-243
No abstract available.
Diagnosis*
;
Optic Neuritis*
6.Neuromyelitis Optica Spectrum Disorder Presented with Acute Memory Loss.
Hyungjin LEE ; Raeyoung KIM ; Kyung Won PARK
Journal of the Korean Neurological Association 2016;34(3):213-216
Neuromyelitis optica spectrum disorder (NMOSD) can present with various symptoms including optic neuritis, transverse myelitis, and area postrema syndrome. However, acute memory loss is an uncommon clinical presentation of NMOSD. We report a patient with NMO-IgG-antibody-positive NMOSD presenting with only acute memory loss, which suggested the presence of bilateral thalamic lesions. This case indicates that NMOSD needs to be considered in the differential diagnosis of acute memory loss.
Area Postrema
;
Diagnosis, Differential
;
Humans
;
Memory Disorders*
;
Memory*
;
Myelitis, Transverse
;
Neuromyelitis Optica*
;
Optic Neuritis
7.Long Spontaneous Remission in Neuromyelitis Optica.
Hyun Gu KANG ; Soo Sung KIM ; Julie JEONG ; Jae Hoon JO ; Myoung Jea YI ; Hak Seung LEE ; Hyun Young PARK ; Hyuk CHANG ; Yo Sik KIM ; Kwang Ho CHO
Journal of the Korean Neurological Association 2011;29(1):52-54
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system characterized by optic neuritis and longitudinal extensive transverse myelitis. The clinical course can be either polyphasic (relapsing-remitting) or monophasic. The relapsing-remitting course is observed in more than 80% of NMO cases, and relapse generally occurs within 1 year in 60% of patients, and within 3 years in 90%. We report a rare case of long spontaneous remission in untreated NMO.
Central Nervous System
;
Demyelinating Diseases
;
Humans
;
Myelitis, Transverse
;
Neuromyelitis Optica
;
Optic Neuritis
;
Recurrence
;
Remission, Spontaneous
8.Association of Optic Neuritis with Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis in Korea
HyoJeong KIM ; Kyung Ah PARK ; Sei Yeul OH ; Ju Hong MIN ; Byoung Joon KIM
Korean Journal of Ophthalmology 2019;33(1):82-90
PURPOSE: To describe the clinical characteristics and course of optic neuritis (ON) and its association with neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) in Korea. METHODS: In this retrospective case series, 125 eyes of 91 Korean patients with ON were included. The medical documents of adult patients with ON were retrospectively reviewed. Patients were assigned into idiopathic ON, NMOSD, and MS groups according to the presence of an association with NMOSD or MS for subgroup analysis. Clinical characteristics, disease course, and visual and systemic prognosis were analyzed. RESULTS: During the mean follow-up of 3.7 years, 73 patients were diagnosed as idiopathic ON, 14 patients were diagnosed as NMOSD, and four patients developed definite MS. At the final visit, there were 13 (13%) eyes out of 100 eyes with idiopathic ON, nine (43%) eyes out of 21 eyes with NMOSD, and one (25%) eye out of four eyes with MS had a severe visual loss of 20 / 200 or less. The mean Expanded Disability Status Scale was 3.1 ± 1.5 in NMOSD and 1.8 ± 1.5 in the MS group at the final visit. In the NMOSD group, 50% of patients showed severe visual loss in at least one eye or were unable to ambulate without assistance at the final visit (5.3 ± 4.4 years after the initial episode of ON). CONCLUSIONS: Fourteen percent of patients showed positive results for NMO-immunoglobulin G test and 50% of patients with NMOSD showed a severe visual loss in at least one eye or were unable to ambulate without assistance. The proportion of MS was relatively low in Korean ON patients.
Adult
;
Follow-Up Studies
;
Humans
;
Korea
;
Multiple Sclerosis
;
Neuromyelitis Optica
;
Optic Neuritis
;
Prognosis
;
Retrospective Studies
9.Initial Pattern of Optic Nerve Enhancement in Korean Patients with Unilateral Optic Neuritis.
Dae Yong SON ; Kyung Ah PARK ; Su Sie SEOK ; Ju Yeun LEE ; Sei Yeul OH
Korean Journal of Ophthalmology 2017;31(1):71-79
PURPOSE: The purpose of this study was to demonstrate whether the pattern of optic nerve enhancement in magnetic resonance imaging (MRI) can help to differentiate between idiopathic optic neuritis (ON), neuromyelitis optica (NMO), and multiple sclerosis (MS) in unilateral ON. METHODS: An MRI of the brain and orbits was obtained in patients with acute unilateral ON. Patients with ON were divided into three groups: NMO, MS, and idiopathic ON. The length and location of the abnormal optic nerve enhancement were compared for ON eyes with and without NMO or MS. The correlation between the pattern of optic nerve enhancement and the outcome of visual function was analyzed. RESULTS: Of the 36 patients with ON who underwent an MRI within 2 weeks of the onset, 19 were diagnosed with idiopathic ON, 9 with NMO, and 8 with MS. Enhancement of the optic nerve occurred in 21 patients (58.3%) and was limited to the orbital segment in 12 patients. Neither the length nor the location of the optic nerve enhancement was significantly correlated with visual functions other than contrast sensitivity or the diagnosis of idiopathic ON, MS, or NMO. Patients with greater extent of optic nerve sheath enhancement and more posterior segment involvement showed higher contrast sensitivity. CONCLUSIONS: Our data revealed that the pattern of optic nerve enhancement was not associated with diagnosis of idiopathic ON, NMO, or MS in Korean patients with unilateral ON. We believe further studies that include different ethnic groups will lead to a more definitive answer on this subject.
Brain
;
Contrast Sensitivity
;
Diagnosis
;
Ethnic Groups
;
Humans
;
Magnetic Resonance Imaging
;
Multiple Sclerosis
;
Neuromyelitis Optica
;
Optic Nerve*
;
Optic Neuritis*
;
Orbit
10.Landmark studies in neuro-ophthalmology
Franz Marie Cruz ; Prem S. Subramanian
Philippine Journal of Ophthalmology 2019;44(1):3-8
High-quality clinical evidence, derived from well-designed and implemented clinical trials, serves to advance clinical
care and to allow physicians to provide the most effective treatments to their patients. The field of ophthalmology,
including the subspecialty of neuro-ophthalmology, abounds with such high-quality clinical trials that provide
Level 1 clinical evidence. This review article summarizes the research design, key findings, and clinical relevance
of select monumental clinical studies in neuro-ophthalmology with the primary goal of providing the readers with
the rationale for current standard of care of various neuro-ophthalmic diseases. This includes the Optic Neuritis
Treatment Trial, Ischemic Optic Neuropathy Decompression Trial, Idiopathic Intracranial Hypertension Treatment
Trial, Rescue of Hereditary Optic Disease Outpatient Study, and Controlled High-Risk Avonex® Multiple Sclerosis
Study
Optic Neuritis
;
Optic Neuropathy, Ischemic
;
Intracranial Hypertension