OBJECTIVE: To explore the change and influence factors of quality of life QOL for drug abusers who accepted methadone maintenance treatment (MMT). METHODS: The questionnaire of QOL-BRIEF was used to measure the level of QQL when patients just entered the study and 6 months after the treatment respectively. The effect of therapy and characteristic of patients on change of QOL was analyzed. RESULTS: The scores in physiological domain, psychological domain, and the total score obviously increased after the treatment. There was no significant difference in the change of QOL between the patients of different dose groups. The QOLs of males and patients with long-time drug use improved significantly after the treatment. CONCLUSION MMT can raise the QOL of drug abusers. Gender and time of drug use may be the risk factors of QOL improvement.
Female ; Humans ; Male ; Methadone ; administration & dosage ; Opioid-Related Disorders ; drug therapy ; Quality of Life ; Substance Withdrawal Syndrome ; drug therapy ; Surveys and Questionnaires

Fentanyl is a fully synthetic opioid with analgesic and anesthetic properties. It has become a primary driver of the deadliest opioid crisis in the United States and elsewhere, consequently imposing devastating social, economic, and health burdens worldwide. However, the neural mechanisms that underlie the behavioral effects of fentanyl and its analogs are largely unknown, and approaches to prevent fentanyl abuse and fentanyl-related overdose deaths are scarce. This review presents the abuse potential and unique pharmacology of fentanyl and elucidates its potential mechanisms of action, including neural circuit dysfunction and neuroinflammation. We discuss recent progress in the development of pharmacological interventions, anti-fentanyl vaccines, anti-fentanyl/heroin conjugate vaccines, and monoclonal antibodies to attenuate fentanyl-seeking and prevent fentanyl-induced respiratory depression. However, translational studies and clinical trials are still lacking. Considering the present opioid crisis, the development of effective pharmacological and immunological strategies to prevent fentanyl abuse and overdose are urgently needed.
Humans ; Fentanyl/therapeutic use* ; Opioid-Related Disorders/drug therapy* ; Drug Overdose/prevention & control* ; Analgesics, Opioid/adverse effects* ; Vaccines/therapeutic use* ; Brain

The use of opioids for the treatment of chronic non-cancer pain has become more widespread recently. Available data support the short-term use of opioids in clearly defined nociceptive and neuropathic pain states. Their use in 'pathological' pain states without a clear diagnosis, such as chronic low back pain, is more contentious. A decision to initiate opioid treatment in these conditions requires careful consideration of benefits and risks; the latter include not only commonly considered adverse effects such as constipation, but also opioid-induced hyperalgesia, abuse, addiction and diversion. Ideally, treatment goals should not only be relief of pain, but also improvement of function. Opioid treatment of chronic non-cancer pain requires informed consent by, and preferably a treatment contract with, the patient. Treatment should be initiated by a trial period with defined endpoints using slow-release or transdermal opioids. Ongoing management of the patient requires ideally a multi-disciplinary setting. Treatment should not be regarded as life-long and can be discontinued by tapering the dose.
Analgesics, Opioid ; adverse effects ; therapeutic use ; Humans ; Hyperalgesia ; chemically induced ; Low Back Pain ; drug therapy ; Pain, Intractable ; drug therapy ; Substance-Related Disorders ; prevention & control

Adult ; Drug Users ; Female ; Humans ; Male ; Methadone ; administration & dosage ; therapeutic use ; Opioid-Related Disorders ; drug therapy ; epidemiology ; psychology ; Patient Acceptance of Health Care ; Quality of Life

INTRODUCTIONBuprenorphine is an opioid partial agonist approved in several countries for the treatment of opioid dependence. It was approved in Singapore in 2002 for this indication, and is more widely available in the primary care setting and can be prescribed by all licensed physicians who have undergone designated training. There is limited literature addressing the risk of its illicit abuse via intravenous self-administration.

CLINICAL PICTUREWe report 2 such cases of the abuse of prescription buprenorphine in the psychiatric consultation-liaison service of a general teaching hospital, the treatment approaches and outcomes.

CONCLUSIONWe also briefly review the indications, uses and abuses of buprenorphine in Singapore, and as reported in other countries, and the roles of primary care physicians, in order to stimulate greater awareness and understanding among specialists and general practitioners, who would encounter these patients in various settings.

Adult ; Buprenorphine ; therapeutic use ; Drug and Narcotic Control ; Female ; Humans ; Male ; Narcotic Antagonists ; therapeutic use ; Opioid-Related Disorders ; rehabilitation ; Pregnancy ; Pregnancy Complications ; diagnosis ; therapy ; Primary Health Care ; Role ; Substance Abuse, Intravenous ; diagnosis ; prevention & control ; therapy

OBJECTIVETo investigate the quality of life of heroin dependent patients with methadone maintenance therapy and its influencing factors.

METHODSTotally 462 heroin dependent patients who were receiving methadone maintenance therapy in Mangshi, Ruili, Longchuan, Yingjiang, Lianghe of Dehong prefecture, Yunnan province were randomly selected using proportional stratified sampling and interviewed with the WHO Quality of Life-BREF (QOL-BREF) in order to understand their quality of life in the fields of physical, psychological, social relationships, and environmental function during 4 weeks ago before interviewing, and the influencing factors of the quality of life.

RESULTSAmong the 462 patients, 451 patients (97.6%) were male and 11 (2.4%) were female. Their average age was (37.80 ± 9.13) years old; 145 patients (31.39%) unmarried, 270 patients (58.44%) were married; 35.93% (166/462) of patients had primary school education, 37.23% (172/462) of patients had senior high school education. The patients had a score of 54.11 ± 6.74 for total quality of life and well being and a score of 14.31 ± 2.23, 13.28 ± 1.79, 13.90 ± 2.52, 12.63 ± 1.77 for physical, psychological, social relationships and environmental function, respectively. The quality of life for physical, psychological, social relationships and environmental function of the group of patients which ages between 30 to 40, unmarried, high middle school and above education, length of drug addiction more than 10 years before receiving treatment, treatment duration less than 6 months, incoming from temporary job were with lower score for total quality of life and well being. The quality of life for physical, psychological was lower for those aged between 16 and 30 when becoming first time drug user, which scores were 14.29 ± 2.25 and 13.22 ± 1.84, respectively. The quality of life for physical, psychological, social relationships of the group of patients which injecting drug only or injecting drug with other manners before receiving treatment were lower, which scores were 13.92 ± 2.25, 13.08 ± 1.67, 13.25 ± 2.60 for injecting drug only and 13.67 ± 2.52, 13.43 ± 1.71, 13.80 ± 2.56 for injecting drug with other manners.

CONCLUSIONAttending and keeping methadone maintenance therapy could improve the quality of life of heroin dependent patients. Age, marriage status, education, time of drug use, treatment duration may be the influential factors.

Acquired Immunodeficiency Syndrome ; complications ; psychology ; Adolescent ; Adult ; China ; Factor Analysis, Statistical ; Female ; Humans ; Male ; Methadone ; administration & dosage ; therapeutic use ; Middle Aged ; Opioid-Related Disorders ; complications ; drug therapy ; psychology ; Quality of Life ; Surveys and Questionnaires ; Young Adult