Trial was made on a new way of administering drugs topically for eye conditions using a collagen corneal shield to deliver the agents. A 4mm perforating incision was made at the center of the rabbit's cornea. Thirty rabbits were used which were devided at random into 3 groups. The first group served as control, the second group was given basic fibroblastic growth factor (bFGF) as eyedrops, and the third groedup collgsu aen shields which had been soaked in bFGF. After 8 days, the maximum pressures that the corneas could stand were significantly different among the 3 groups (p

Ascorbic acid was found to inhibit the activity of collagenase in vitro significantly at the concentration of 56.7mmlo/L and completely at the concentration of 85.0mmol/L. This effect was destroyed by heat. The experiment explained further the useful action of topical ascorbic acid in the treatment of corneal alkaline burn and ulcer.

To evaluate the role and efficacy of vitrectomy in the treatment of eye injuries in children with posterior segment involvement, forty-six eyes in 45 children aged under 16 with injuries involved posterior segment treated with pars plana vitreetomy are studied retrospectively. Six eyes underwent vitreetomy only, the others combined with seleral buekling and/ or gas-fluid exchange, and rarely, silicon oil tam-ponade; Seventeen eyes with lensectomy. Thirty-four (73.91%) of the 46 eyes achieved surgical success. Of 13 (28.26%) eyes with retinal detachments, six (46.15%) achieved reatachment. The failure of surgery was mainly due to retinal detachment, which mostly characterized by anterior proliferative vitreoretinopathy (PVR). We conclude that pars plana vitrectomy is an important therapeutic operation for eye injury in children with posterior segment involvement. The key factor that influence the outcome of eye injury in children is the treatment of traumatic retinal deatchment.

The series of 441 cases of orbital tumor comprised 245 males and 196 females whose age ranged from 6 months to 60 years.The tumors of high incidence in order of impor- tance were hemangioma,dermoid cyst,mu- cocele,meningioma,and optic neuroglioma. A modified surgical approach was mode for complete removal of tumors located in the poste,ronasal aspect of the orbit.Besides, other approaches to the orbital apex were also attempted in addition to regular routes.

Cyelocryotherapy using nitrogen monoxide was performed on 28 patients (28 eyes) with secondary glaucoma following penetrating keratoplasty, which had failed to respond to anti-glaucoma drugs and routine filtering procedures. All patients were followed up for more than one year. Intraoeular pressure was well under control in 89% of the eyes. The graft remained clear in 85%. The effective visual function was preserved in 82%. Our study showed that timely intervention, precisely controlled temperature) timing, extent of cryotherapy, and post-operative use of anti-rejection agents were key factors to suceess. Over-treatment, which may lead to atrophy of the eye, must be avoided. The effort should not be given up following under-treat-ment in the initial procedure.

The pharmacokineties of intravitreally injected tetrandrine was monitered by high-performance liquid chromatography (HPLC). After intravitreal injection of tetrandrine in rabbits' eyes, aqueous humor and vitreous were drawn at different times for determination. The drug concentration in the aqueus humor and vitreous was measured by HPLC. The results showed that the concentration-time curves of tetr-andrinc in the vitreous fitted in with a two-compar-tment open model with half-life periods of 1.02 hour(?) and 16.62 hour (?) respectively. The drug concentration in aqueous humor was low, with a peak value of 6.73?g/ml at two hour.

24 cases(25 eyes)of traumatic cataract with various complications were performed combined operations such as vitrectomy and extracapsular lensectomy from behind to leave the anterior capsule followed by imp- lantation of IOL,vitrectomy and removal of intraocular foreign body followed by secon- dary extracapsular extraction of the cataract and IOL implantation when the lens became opaque,and removal of intraocular foreign body with extracapsular extraction of the lens and IOL implantation.The position of incision,the method of anterior capsulotomy and nucleus delivery,the irrigation and aspiration of lens cortex and the timing of the operation were discussed.

An orthotopic penetrating keratoplasty model was used to study the immunosuppressive effect of FK 506 on the corneal re-allograft in Lewis rats. Nine eyes received subconjunctival injections of FK 506 (0.2mg/kg) once every three days. Physiological saline was used in 9 eyes as control. The results showed that FK 506 effected a significant delay in allograft rejection with a mean survival time of 9.56?0.96 days VS 6.13?0.93 days in the control group (P

Spherical aberration is the major cause which affects the functional vision of the patients implanted with spherical intraocular lenses (IOLs). Aspheric IOLs are designed to eliminate the aberration like the nature lens, thus they can produce better visual quality. If it is feasible to customize IOL design to the individual cataract patient, aspheric IOLs may substitute the traditional spherical IOLs and become the trend of IOLs.

The level of cataract basic research in China still exist significant difference compared with some developed countries. It mainly demonstrates on lacking of creativity in selecting research subjects, low-level reproducibility in research contents, and confusion or misunderstanding of basic concepts, etc. We should have a clear idea to this and enhance our research level in the future.