We encountered a case of an accidental epidural injection of ondansetron through an epidural catheter. No neurological complications were noted. This case highlights the need for more attention to minimize the risk of epidural injections.
Catheters ; Injections, Epidural* ; Ondansetron*

No abstract available.
Nausea* ; Ondansetron* ; Vomiting*

No abstract available.
Ondansetron* ; Postoperative Nausea and Vomiting*

No abstract available.
Cisplatin* ; Humans ; Nausea* ; Ondansetron* ; Vomiting*

No abstract available.
Antiemetics* ; Drug Therapy, Combination* ; Humans ; Ondansetron*

No abstract available.
Antiemetics* ; Cisplatin* ; Dexamethasone* ; Humans ; Lorazepam* ; Metoclopramide* ; Ondansetron*

BACKGROUND: Intravenous injection of rocuronium produces intense discomfort at the site of injection in conscious patient. The purpose of this study was 2 folds; First, to determine the incidence of pain associated IV injection of rocuronium in adult patients. Second, to determine whether pretreatment with IV ondansetron affects the incidence of pain associated with the injection of rocuronium. METHODS: Eighty adult patients were randomly assigned to four groups. Before general anesthesia was induced with thiopental sodium (5 mg/ml), manual occlusion (70 mmHg) with tourniquet of venous inflow was performed. Randomly associated 20 patients received 4 ml of normal saline as a placebo control (Group 1). Other 60 patients allocated randomly to one of three groups: ondansetron 4 mg (Group 2), 6 mg (Group 3), 8 mg (Group 4) respectively. The patients' pain response to rocuronium injection was graded with using Memis' 4-point scale and withdrawal response was graded with using Kim's 4-point scale. RESULTS: Nineteen patients (95%) in the group 1, 18 patients (90%) in the group 2, 19 patients (95%) in the group 3, and 14 patients (85%) in the group 4 reported pain. Moderate to sever pain was 17 patients (85%), in the group 1, 11 patients (55%) in the group 2, 9 patients (45%) in the group 3, and 1 patient (5%) in the group 4. CONCLUSIONS: Ondansetron 4 mg, 6 mg, and 8 mg IV given before administration of rocuronium did not reduce incidence of pain on injection of rocuronium but significantly reduced severity of pain on injection of rocuronium and the 8 mg was more effective.
Adult* ; Anesthesia, General ; Humans ; Incidence ; Injections, Intravenous ; Ondansetron* ; Thiopental ; Tourniquets

No abstract available.
Drug Therapy, Combination* ; Metoclopramide* ; Ondansetron* ; Prospective Studies* ; Vomiting*

BACKGROUND: The pain caused by injection of propofol is known to be related to the concentration of aqueous free propofol. Microemulsion propofol can cause a serious pain because it has 7 times higher concentration of aqueous free propofol. We used ondansetron, lidocaine, ondansetron lidocaine as pretreatment to compare the effect for injection pain of microemulsion propofol. METHODS: 75 patients, ASA physical status I or II were enrolled. We randomly allocated into Group L (n = 25) received 2% lidocaine 40 mg, group O (n = 25) received ondansetron 4 mg and group M (n = 25) received ondansetron 4 mg plus 2% lidocaine 40 mg as pretreatment. After instituting standard monitoring, the venous drainage was occluded using a pneumatic tourniquet at 25 cm proximal to venous line. The patients were pretreated over a period of 15 seconds with one of the pretreatment drug. After releasing the tourniquet, microemulsion propofol was injected. We asked the patient about degree of injection pain until loss of consciousness, by using 0-100 point pain intensity numerical rating scale (PI-NRS). In the recovery room, we asked the patient whether they recall injection pain. RESULTS: There were significant differences in the group L and the group M compared with group O on PI-NRS (P < 0.05). The incidence of injection pain was significantly lower in group L and group M than group O. CONCLUSIONS: Pretreatment of lidocaine and lidocaine + ondansetron is more effective than ondansetron alone for reducing pain on injection of microemulsion propofol.
Drainage ; Humans ; Incidence ; Lidocaine ; Ondansetron ; Propofol ; Recovery Room ; Tourniquets ; Unconsciousness

BACKGROUND:Rocuronium is given for precurarization, timing or priming before the induction of anesthesia. The incidence of pain on injecting rocuronium is high and can be very distressing. The goal of this study was to evaluate whether pretreating lidocaine, fentanyl, or ondansetron i.v. can decrease the incidence and severity of injection pain. METHODS: One hundred and fifty patients were randomly allocated into five groups: patients in groups I, II, III, IV, and V received saline (3 ml), lidocaine 30 mg, lidocaine 50 mg, fentanyl 100microgram, or ondansetron 4 mg after manually occluding the forearm. The occlusion was released and rocuronium 0.6 mg/kg was injected. The patients were then observed and asked whether they had pain in the arm, and responses were assessed. RESULTS: The mean (median) pain scores in gorups I, II, III, IV, and V were 1.9 (2), 1.0 (1), 0.73 (1), 1.33 (1), and 1.2 (1), respectively. We found that 7%, 37%, 47%, 20%, and 20% of patients in groups I, II, III, IV and V reported no pain. Moderate to severe pain was seen in 60%, 33%, 20%, 40%, and 33% of patients in groups I, II, III, IV, and V, respectively. CONCLUSIONS: Lidocaine, fentanyl, and ondansetron reduced rocuronium injection pain. Of these drugs, lidocaine seems to be the most effective. Fentanyl and ondansetron proved less effective than lidocaine.
Anesthesia ; Arm ; Fentanyl* ; Forearm ; Humans ; Incidence ; Lidocaine* ; Ondansetron*