1.Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy
Xu WU ; Chun YIN ; Jiang MA ; Stella CHAI ; Chunyuan ZHANG ; Sheng YAO ; Onat KADIOGLU ; Thomas EFFERTH ; Yang YE ; Kenneth Kin-Wah TO ; Ge LIN
Acta Pharmaceutica Sinica B 2021;11(7):1885-1902
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of
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