Objective To evaluate the efficacy and safety of interventional therapy in structural heart diseases in 38 PLA hospitals.Methods Data including patient number underwent interventional therapy for structural heart disease, procedure details, immediate procedural complications were retrospectively collected in all the military hospitals between January 2005 and December 2006.Results Successful interventional therapy was achieved in 8692 out of 8862 patients (98.08%) with structural heart disease.Transcatheter closure of ventricular septal defect ( VSD), atrial septal defect (ASD) and patent ductus arteriosus (PDA), and percutaneous balloon dilatation of mitral valve stenosis (MS) and pulmonary valve stenosis (PS) were the most performed procedures (97.99%).Up to 91.23% patients underwent transcatheter closure with domestic devices.The incidence of procedure-related complications was 4.33% (n = 384 ) which were most frequently associated with VSD closure.The commonest procedural complications included conduction blockades ( n = 260), residue shunt ( n = 42), device detachment ( n = 30) and tricuspid incompetence (n = 22).Although the procedures performed in 2005 and 2006 increased 57.32% compared with those in 2003 and 2004, the success rate and the incidence of complications remained unchanged.conclusion Percutaneous treatment of structural heart disease is a safe and feasible alternative to surgery.Somelate complications arise long after the treatment, which suggests the importance of long-term follow-up for those patients who hare undergone interrentional therapy.