1.CORM-2-entrapped ultradeformable liposomes ameliorate acute skin inflammation in an ear edema model
Gwan-Yeong LEE ; Alam ZEB ; Eun-Hye KIM ; Beomseon SUH ; Young-Jun SHIN ; Donghyun KIM ; Kyoung-Won KIM ; Yeong-Hwan CHOE ; Ho-Ik CHOI ; Cheol-Ho LEE ; Omer Salman QURESHI ; In-Bo HAN ; Sun-Young CHANG ; Ok-Nam BAE ; Jin-Ki KIM
Acta Pharmaceutica Sinica B 2020;10(12):2362-2373
The short release half-life of carbon monoxide (CO) is a major obstacle to the effective therapeutic use of carbon monoxide-releasing molecule-2 (CORM-2). The potential of CORM-2-entrapped ultradeformable liposomes (CORM-2-UDLs) to enhance the release half-life of CO and alleviate skin inflammation was investigated in the present study. CORM-2-UDLs were prepared by using soy phosphatidylcholine to form lipid bilayers and Tween 80 as an edge activator. The deformability of CORM-2-UDLs was measured and compared with that of conventional liposomes by passing formulations through a filter device at a constant pressure. The release profile of CO from CORM-2-UDLs was evaluated by myoglobin assay.
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