1.Oliguria and acute renal dysfunction in a six-month-old infant.
Ya-Jie CUI ; Chun-Lan SONG ; Yi-Bing CHENG
Chinese Journal of Contemporary Pediatrics 2017;19(2):203-207
The infant (a girl aged 6 months) was admitted to the hospital because of oliguria and acute renal dysfunction. The laboratory examination results showed serious metabolic acidosis and increased blood urea nitrogen and serum creatinine levels. The patient continued to be anuric after 10 days of treatment with continuous renal replacement therapy (CRRT). she died a day later. The family history showed that the patient's sister died of acute renal failure 6 months after birth. The genomic sequencing results showed AGXT mutation in the patient and confirmed the diagnosis of primary hyperoxaluria type 1 (PH1). Her parents were heterozygous carriers. PH1 should be considered when the children have abnormal renal function or recurrent renal calculi or have a family history of these symptoms. AGXT gene analysis is an important method for PH1 diagnosis.
Acute Kidney Injury
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etiology
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Female
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Humans
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Hyperoxaluria, Primary
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complications
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Infant
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Mutation
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Oliguria
;
etiology
;
Transaminases
;
genetics
2.Impact of oliguria during lung surgery on postoperative acute kidney injury.
Zhao Ting MENG ; Dong Liang MU
Journal of Peking University(Health Sciences) 2020;53(1):188-194
OBJECTIVE:
To explore the influence of intraoperative urine volume on postoperative acute kidney injury (AKI) and the independent risk factors of AKI.
METHODS:
This was a retrospective cohort study recruiting patients who received selective pulmonary resection under general anesthesia in Peking University First Hospital from July, 2017 to June, 2019. The patients were divided into the AKI group and the control group according to whether they developed postoperative AKI or not. Firstly, univariate analysis was used to analyze the relationship between perioperative variables and postoperative AKI. Secondly, receiver operating characteristic (ROC) curve was used to explore the predictive value of intraoperative urine output for postoperative AKI. The nearest four cutoff values [with the interval of 0.1 mL/(kg·h)] at maximum Youden index were used as cutoff values of oliguria. Then univariate analysis was used to explore the relationship between oliguria defined by these four cutoff values and the risk of AKI. And the cutoff value with maximum OR was chosen as the threshold of oliguria in this study. Lastly, the variables with P < 0.10 in the univariate analysis were selected for inclusion in a multivariate Logistic model to analyze the independent predictors of postoperative AKI.
RESULTS:
A total of 1 393 patients were enrolled in the study. The incidence of postoperative AKI was 2.2%. ROC curve analysis showed that the area under curve (AUC) of intraoperative urine volume used for predicting postoperative AKI was 0.636 (P=0.009), and the cutoff value of oliguria was 0.785 mL/(kg·h) when Youden index was maximum (Youden index =0.234, sensitivity =48.4%, specificity =75.0%). Furthermore, 0.7, 0.8, 0.9, 1.0 mL/(kg·h) and the traditional cutoff value of 0.5 mL/(kg·h) were used to analyze the influence of oliguria on postoperative AKI. Univariate analysis showed that, when 0.8 mL/(kg·h) was selected as the threshold of oliguria, the patients with oliguria had the most significantly increased risk of AKI (AKI group 48.4% vs. control group 25.3%, OR=2.774, 95%CI 1.357-5.671, P=0.004). Multivariate regression analysis showed that intraoperative urine output < 0.8 mL/(kg·h) was one of the independent risk factors of postoperative AKI (OR=2.698, 95%CI 1.260-5.778, P=0.011). The other two were preoperative hemoglobin ≤120.0 g/L (OR=3.605, 95%CI 1.545-8.412, P=0.003) and preoperative estimated glomerular filtration rate < 30 mL/(min·1.73 m2) (OR=11.009, 95%CI 1.813-66.843, P=0.009).
CONCLUSION
Oliguria is an independent risk fact or of postoperative AKI after pulmonary resection, and urine volume < 0.8 mL/(kg·h) is a possible screening criterium.
Acute Kidney Injury/etiology*
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Humans
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Lung
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Oliguria/etiology*
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Postoperative Complications/etiology*
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Postoperative Period
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Retrospective Studies
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Risk Factors
3.Masked Hydronephrosis.
Lae Young JUNG ; Kyung Pyo KANG ; Won KIM ; Sung Kwang PARK ; Sik LEE
The Korean Journal of Internal Medicine 2012;27(2):244-244
No abstract available.
Aged
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Colitis, Ischemic/complications/*diagnosis/therapy
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Cystitis/*diagnosis/etiology
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Dehydration/etiology
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Diarrhea/etiology
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Female
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Fluid Therapy
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Humans
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Hydronephrosis/*diagnosis/etiology
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Oliguria/etiology
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Predictive Value of Tests
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Radiation Injuries/*diagnosis/etiology
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Tomography, X-Ray Computed
4.Primary lymphoedema at an unusual location triggered by nephrotic syndrome.
Yilmaz TABEL ; Ilke MUNGAN ; Ahmet SIGIRCI ; Serdal GUNGOR
Annals of the Academy of Medicine, Singapore 2009;38(7):636-633
INTRODUCTIONLymphoedema results from impaired lymphatic transport leading to the pathologic accumulation of protein-rich lymphatic fluid in the interstitial space, most commonly in the extremities. Primary lymphoedema, a developmental abnormality of the lymphatic system, may become evident later in life when a triggering event exceeds the capacity of normal lymphatic flow.
CLINICAL PICTUREWe present a 3-year-old nephrotic syndrome patient with an unusual localisation for primary lymphoedema.
TREATMENT AND OUTCOMEThe patient was treated with conservative approach and she was cured.
CONCLUSIONIn this particular case, lymphoedema developed at an unusual localisation, which has not been recorded before.
Albumins ; administration & dosage ; Child, Preschool ; Diuretics ; administration & dosage ; Female ; Furosemide ; administration & dosage ; Humans ; Infusions, Intravenous ; Lymphedema ; drug therapy ; etiology ; Nephrotic Syndrome ; complications ; Oliguria ; etiology
5.Unintended Cannulation of the Subclavian Artery in a 65-Year-Old-Female for Temporary Hemodialysis Vascular Access: Management and Prevention.
Jeong Im CHOI ; Sung Gun CHO ; Joo Hark YI ; Sang Woong HAN ; Ho Jung KIM
Journal of Korean Medical Science 2012;27(10):1265-1268
Ultrasound-guided cannulation of a large-bore catheter into the internal jugular vein was performed to provide temporary hemodialysis vascular access for uremia in a 65-yr-old woman with acute renal failure and sepsis superimposed on chronic renal failure. Despite the absence of any clinical evidence such as bleeding or hematoma during the procedure, a chest x-ray and computed tomographic angiogram of the neck showed that the catheter had inadvertently been inserted into the subclavian artery. Without immediately removing the catheter and applying manual external compression, the arterial misplacement of the hemodialysis catheter was successfully managed by open surgical repair. The present case suggests that attention needs to be paid to preventing iatrogenic arterial cannulation during central vein catheterization with a large-bore catheter and to the management of its potentially devastating complications, since central vein catheterization is frequently performed by nephrologists as a common clinical procedure to provide temporary hemodialysis vascular access.
Acidosis/complications
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Acute Disease
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Aged
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Catheterization, Central Venous/*adverse effects
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Female
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Hemorrhage/etiology
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Humans
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Kidney Failure, Chronic/*diagnosis
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Medical Errors/*prevention & control
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Oliguria/complications
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Renal Dialysis
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Sepsis/etiology
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Subclavian Artery/injuries/*radiography/surgery
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Tomography, X-Ray Computed
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Uremia/etiology