Azoospermia accounted for 10-15% of infertility cases. It is classified into 2 groups: obstructive and non-obstructive azoospermia. Infertility couples due to azoospermia can be treated by some assisted reproductive techniques, such as epididymal sperm aspiration (MESA and PESA techniques), testicular sperm aspiration (TESA) or testicular sperm extraction (TESE). The success can be expected for cases with obstructive azoospermia.
Infertility ; Oligospermia ; Infertility, Male

Objective: To determine the pregnancy rate after intrauterine insemination using samples with. processed total motile count of 1.0 x 106 and less and describe the semen quality profile of Filipino males with severe male factor infertility in both the raw and processed semen samples. Design: Retrospective descriptive study. Setting: Andrology Laboratory, St. Luke's Medical Center. Patients: 307 infertile Filipino couples who underwent 426 IUI cycles. Main Outcome Measures: Pregnancy rate (PR) after intrauterine insemination. Results: A total of 10 pregnancies were obtained out of 426 IUI cycles, for a pregnancy rate per cycle of 2.4%. Seven of these eventually delivered to term, for a live birth rate of 1.6%. Among those who did not get pregnant with IUI, 8 had spontaneous pregnancies within 1 to 5 year period of follow-up for a spontaneous pregnancy rate of 1.9%. As expected, all the semen parameters analysed showed improvement after semen processing in all subjects. However, these improvements failed to result in a more acceptable pregnancy rate. Among the parameters, morphology was notably better among those who had pregnancies. Conclusion: The chance of pregnancy with IUI using semen samples with processed total motile count of 1.0 x 106 or less is relatively low. For these couples, it may be more prudent to proceed directly to IVF-ICSI than to try several cycles of IUI in futility.
INTRAUTERINE INSEMINATION ; SEVERE OLIGOSPERMIA

A retrospective study was performed on 2,774 infertile couples treated in National Institute of protection of Mother and Newborn from January 1995 to December 1995. 897 male subjects were selected according to semen analysis. The subjects were classified, and divided into primary and secondary infertility groups. Semen analysis shows: 496 cases (53.30%) with normal semen parameters. 204 cases (22.7%) were azoospermia. 233 cases (25.9%) were oligospermia (20 millions/ml sperm). 268 cases (30%) had  20% of strong spermatozoytes. 231 cases (25.7%) were oligospermia with  20% of strong spermatozoytes. All the male infertile patients have required the IAD practice for their partners, therefore a 'Bank of Spermatozoytes' must be recommended
Infertility ; Oligospermia ; Infertility, Male ; Therapeutics

Scatter-air ratios are used for the purpose of calculating scattered dose in the medium. The computation of the primary and the scattered dose separately is particularly useful in the dosimetry of irregular fields with shielding block in radiation field, dose distribution of scattered radiation using 18MeV Linear accelerator and Co-60 teletherapy measured. The effect of scattered radiation dose by protecting block was been ignored in radiation therapy, 2-3% of scattered radiation may be 90-200cGy which could be influence vital complication such as cataract, oligospermia or sterility. So that exact calculate scattered radiation by protecting block exactly for irregular field c small protection of vital organ is very important. The purpose of this article is to calculate scattered radiation by protecting block exactly for irregular field c Linac or Co-60 irradiation and to applicate these data in clinical radiation field. Authors could obtain following results. 1. The lesser angle between shielding block showed more scattered radiation. 2. With decreasing distance between shielding blocks, the dependent of scattered radiation were increased. 3. Output of 18 MeV Linear accelerator and Co-60 was related linear proportion on field size, but independent according to the size of shielding block in 18 MeV Linear accelerator.
Cataract ; Infertility ; Male ; Oligospermia ; Particle Accelerators

OBJECTIVETo analyze the risk of pregnancy in the woman whose husband has severe oligospermia after vasectomy.

METHODSA woman was found pregnant, whose husband, a 35-year-old man, had received vasectomy two years before. Two seminal examinations at the interval of 7 days showed the total number of motile sperm to be 0.047 x 10(6) and 0.044 x 10(6), respectively. DNA analysis after miscarriage exhibited a 99.9996% relative chance paternity (RCP).

RESULTSDNA analysis proved the biological paternity of the man with severe oligospermia after vasectomy.

CONCLUSIONA man with severe oligospermia after vasectomy could make his wife pregnant.

Male infertility is a complex disease affecting the reproduction of childbearing couples, for which genetic polymorphism of spermatogenesis genes is an important genetic pathogenic factor. Lots of genes closely related with spermatogenesis have been successfully identified through the gene knockout technology. Spermatogenesis impairment related genes include those associated with expression enzymes, receptors, cell apoptosis, transcription regulation, and so on. The genetic susceptibility of these genes, infection, and environment jointly contribute to non-obstructive azoospermia and oligozoospermia in males. The analysis of the single nucleotide polymorphism (SNP) of spermatogenesis impairment related genes helps explain the possible mechanism of pathogenesis at the molecular level, and provides theoretical evidence for the clinical diagnosis and treatment of male infertility. The article focuses on the correlation of the SNPs of spermatogenesis impairment related genes with azoospermia and oligozoospermia.
Humans ; Infertility, Male ; genetics ; Male ; Oligospermia ; genetics ; Polymorphism, Single Nucleotide

Men with azoospermia or severe oligospermia (< 5 x 10(6)/ml) should have genetic testing to identify the reason for male infertility before treatment. Identification of obstructive azoospermia (OA) or non-obstructive azoospermia (NOA) is essential because genetic testing differs for OA (which has normal testicular function, testicular volume, and FSH) versus NOA (which has small, soft testes and increased FSH). Among patients with NOA, history and physical examination along with laboratory testing is required to choose genetic testing specifically for primary testicular failure or congenital hypogonadotropic hypogonadism (HH). Genetic testing options include cystic fibrosis transmembrane conductance regulator (CFTR) testing for men with OA due to congenital absence of the vas, while karyotype, Y chromosome microdeletions (YCMD), and other specific genetic tests may be indicated if patient has severe oligospermia or NOA. These genetic tests help to identify which patients may benefit from medical and/or surgical intervention. The most recent techniques for genetic analysis will improve diagnosis and management of male infertility.
Genetic Testing ; Humans ; Infertility, Male ; genetics ; Male ; Oligospermia ; genetics

OBJECTIVESTo test the serum sexual hormone and sperm cytology in aspermia patients.

METHODSRadioimmunoassay (RIA) and Wright-Giemsa stain were used to detect serum sexual hormone and sperm cytology in 45 aspermia patients.

RESULTSAmong the 45 patients, spermatogenetic cells were detected in 16 patients(35.6%). The level of serum testerone were decreased in 16 patients, and FSH, LH were increased in 13 cases as well as that of PRL in 4 cases.

CONCLUSIONSThese results suggested that the testis function was demaged, the ratio of T/LH could further reflect the function of Leydig cells, the detection of PRL were significant only in diagnosis of aspermia induced by hypermia. It is an important index in identifying obstructive and non-obstructive aspermia and has important significance in estimating the extention of testis demage and commanding the clinical treatment of serum hormone detection and sperm cell analysis.

OBJECTIVE: To observe the clinical effect of herb-separated moxibustion on segmental conception vessel combined with low-frequency transcutaneous electrical acupoint stimulation (TEAS) for asthenospermia and oligospermia. METHODS: A total of 105 patients with asthenospermia and oligospermia were randomly divided into a combination group, a TEAS group and a medication group, 35 cases in each one. In the medication group, vitamin E capsules, coenzyme Q10 capsules， RESULTS: Compared before treatment, except for the sperm morphology 2 months into treatment in the medication group, the semen routine indexes 2, 3 months into treatment were improved in the 3 groups ( CONCLUSION Herb-separated moxibustion on segmental conception vessel combined with low-frequency TEAS can improve semen routine, reduce sperm oxidative stress damage for patients with asthenospermia and oligospermia, and the clinical efficacy is better than the medication and TEAS.
Acupuncture Points ; Humans ; Male ; Moxibustion ; Oligospermia/therapy* ; Sperm Motility ; Spermatozoa

Male ; Humans ; Avena ; Infertility, Male/genetics* ; Oligospermia/genetics* ; Asthenozoospermia ; Spermatozoa