1.Y chromosome microdeletions in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome.
Yong Ho LEE ; Tak KIM ; Mee Hye KIM ; Young Tae KIM ; Sun Haeng KIM
Experimental & Molecular Medicine 2000;32(4):231-234
The objective of this study was to elucidate the cause of the spermatogenic defect in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome. Genomic DNAs from 9 cases of Korean idiopathic azoospermia and 6 of Korean non-mosaic type of Klinefelter syndrome were used for the detection of Y chromosome microdeletions by polymerase chain reaction using 60 primers. Microdeletions of the Y chromosome were found in 1 of 9 (11.1%) patients with idiopathic azoospermia, whereas none was deleted in non-mosaic type of Klinefelter syndrome. This result suggests that Y chromosome microdeletions could be one of the etiologic factors in idiopathic azoospermia.
Gene Dosage
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Human
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Klinefelter Syndrome/classification/*genetics
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Male
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Oligospermia/classification/*genetics
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Polymerase Chain Reaction
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*Sequence Deletion
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Sequence Tagged Sites
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Spermatogenesis
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X Chromosome/genetics
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Y Chromosome/*genetics