1.Effects of co-administration of Ganoderma terpenoid extract with chloroquine on inflammatory markers and antioxidant status in Plasmodium berghei-infected mice.
Olarewaju M OLUBA ; Oghenerobor B AKPOR ; Feyikemi D ADEBIYI ; Sunday J JOSIAH ; Olayinka O ALABI ; Ayoola O SHOYOMBO ; Augustine O OLUSOLA
Journal of Integrative Medicine 2020;18(6):522-529
OBJECTIVE:
To understand the protective effects of Ganoderma terpenoid extract (GTE) against Plasmodium berghei-malarial infection in mice, the present study was carried out to evaluate the effects of GTE in combination with chloroquine disulphate (CQ) on erythrocyte-selected inflammatory markers and antioxidant defense status in P. berghei-infected mice.
METHODS:
P. berghei-infected mice were divided into six groups: infected control (IC) group, administered 1 mL Tween 20; GTE
RESULTS:
Infected mice treated with a combination of GTE and CQ (GT
CONCLUSION
Data generated in this study showed that GTE enhanced the anti-plasmodial action of CQ in mice through its anti-inflammatory and antioxidant activities.
Result Analysis
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