No abstract available.

To address the possible prognostic value of p53 and Bcl-2 proteins in non-small cell lung carcinomas (NSCLCs), the authors studied 43 cases of NSCLCs diagnosed between the years 1990 to 1995 at Pusan National University Hospital. The patients were treated either by pneumonectomy or lobectomy of the lung. The expression of p53 and Bcl-2 proteins was semiquantitatively analyzed in paraffin sections by immunohistochemical method and correlated with clinicopathologic prognostic parameters of NSCLCs. Overexpression of the p53 protein was found in 31 cases (72.1%) of the 43 NSCLCs. Overexpression of the p53 protein was significantly correlated with the decreasing degree of histologic differentiation, increasing tumor stage, and cigarette smoking. Bcl-2 expression was found in 19 cases (44.2%) of the 43 NSCLCs. Increased expression of the Bcl-2 protein was significantly correlated only with decreasing tumor stage. An inverse relationship was found between p53 and Bcl-2 proteins, but it was not statistically significant. Thus p53 and Bcl-2 proteins, as demonstrated immunohistochemically in routine paraffin sections, could be of value in prediction of the aggressiveness and prognosis of NSCLCs, in agreement with the central role of p53 and Bcl-2 proteins in the evolution of NSCLCs associated with cigarette smoking.
Busan ; Humans ; Immunohistochemistry ; Lung* ; Paraffin ; Pneumonectomy ; Prognosis ; Smoking

PURPOSE: To investigate audiometery and characteristics related to tinnitus in tinnitus patients. and to understand the relationship between the discomfort of tinnitus and the quality of life. Methods: The subjects were 110 patients with tinnitus. The data were collected using tinnitus handicap questionnaire. quality of life, and pure tone audiometry, which measured hearing level in dB and frequency in Hz matching of tinnitus. RESULTS: Majority of tinnitus patients (75.5%~81.8%) had normal auditory sensation. but 82.7% of patients indicated that they have heard tinnitus frequently. or always, and the major sounds of tinnitus were wing, wung, wang, The matching sounds of tinnitus had various range in hearing level(dB) and frequency(Hz). Tinnitus patients reported moderate levels of the discomfort of tinnitus and the quality of life, and there were negative correlation between the discomfort of tinnitus and the quality of life(r=-.314, p .00l). CONCLUSION: These findings suggest that special attention is needed for tinnitus patients because the physical. psychological. and social impacts of tinnitus could be decrease their quality of life, Specialized nursing intervention considering specific conditions related to tinnitus is required to solve various health problems of tinnitus patients.
Audiometry ; Hearing ; Humans ; Nursing ; Quality of Life* ; Surveys and Questionnaires ; Sensation ; Social Change ; Tinnitus*

Background: Although there are various interventions for eating disorders in type 1 diabetes patients, it is difficult to interpret them comprehensively. The purpose of this study is to analyze eating disorder intervention studies in type 1 diabetes patients and to compare the characteristics of each study. Methods: For this study, PICOTS-SD was established. We searched studies published in Korean and English from 2000 to 2020 in KCI, RISS, NDSL, KISS, MEDLINE, CINAHL, Pubmed, and Embase. Results: For the intervention of eating disorders in patients with type 1 diabetes, psycho-education and self-compassion programs were implemented. The intervention period varied from 4 to 6 weeks, and physiological variables, eating disorder variables, and emotional variables were used interventions. But the number of participants was small and the results of the study were inconsistent. Conclusions Through this study, the possibility of resolving the difficulties of eating disorder intervention in type 1 diabetes patients was confirmed. In the future, more randomized controlled trials with larger samples are needed to extend the evidence base.

The halophilic bacterium, Vibrio vulnificus, causes acute fulminating wound infections and septicemia in human. Especially the septicemia shows high mortality above 50%. In Korea, septicemia by V. vulnificus was reported at westem and southern coast in every year. Here, we try to isolate this V. vulnipcus at Kyoung-nam area and coast of Pusan during 1996. Purposed sites were Dadaepo, Songjung, Chungsapo and Mipo of Pusan and Kijang, Ilkuang, Juksoung, Dongam, Waljun and Chilam of southern sea. Total 40 strains of V. vulnipcus were isolated from sea samples. Biochemical characteristics of isolated V. vulnificus were almost same with reference strain V. vulnificus ATCC 27562 on Farmer's tests and on API 20E kit test. V. vulnificus isolates in 1996, fermented cellobiose and salicin but arabinose. and had resistance to 7% sodium chloride.
Arabinose ; Busan* ; Cellobiose ; Humans ; Korea* ; Mortality ; Sepsis ; Sodium Chloride ; Vibrio vulnificus* ; Vibrio* ; Wound Infection

PURPOSE: The purpose of this study was to evaluate levels and correlations of epilepsy specific knowledge, attitude and anxiety in mothers of children with epilepsy METHODS: Participants were 176 mothers of children with epilepsy living in B and Y cities. Data were analyzed using descriptive statistics, t-test, ANOVA, and Pearson correlation coefficients with the SPSS 21.0 program. RESULTS: Participants scored 57.2 (+/-1.7) out of 100 points on epilepsy-related knowledge; 35.6 (+/-5.0) out of 48 points on attitude toward epilepsy; 58.1 (+/-15.3) out of 85 on anxiety related to a child's epileptic condition. The participants had higher levels of epilepsy-related knowledge if their family monthly income was three million KRW or higher (t=-2.92, p=.004); if there was no side effect from the medication (t=-2.91, p=.004); and if the mothers' perception of the child's health was good (F=6.181, p=.001). There was a positive correlation between knowledge and attitude related to epilepsy (r=.321, p<.001), and a negative correlation between knowledge and anxiety (r=-.257, p=.001). CONCLUSION: Findings indicate that interventions which reduce mothers' anxiety by providing epilepsy specific knowledge and help to achieve more positive attitudes to better ways of coping with child's disease.
Anxiety* ; Child* ; Epilepsy* ; Humans ; Mothers*

No abstract available.
Hypertrophy, Left Ventricular* ; Kidney Failure, Chronic*

PURPOSE: This study aims to identify the effect of pediatric fall prevention education with leaflets and picture books on the fall-related knowledge and preventive behaviors in caregivers of inpatient children. METHODS: This study is a non-equivalent control group non-synchronized design. It divided 62 caregivers of inpatient children aged 5 and under into an experimental group and a control group in P general hospital located in B City. RESULTS: Fall related knowledge score in the experimental group was increased by 2 points after the intervention and the score in the comparison group was increased by 0.1 points. The difference after the intervention in fall related knowledge scores between the two groups was statistically significant (t=7.67, p<.001). The fall related prevention behavior score of the experimental group increased by 9.3 points after the intervention, and the score of the comparison group increased by 2.5 points. The difference in the scores of fall related prevention behaviors between the two groups was statistically significant (t=5.71, p<.001). CONCLUSION: Pediatric inpatient fall prevention education using leaflets and picture books can improve caregivers' fall-related knowledge and preventive behaviors. In turn, this can reduce children's falls in pediatric wards in general hospitals.
Accident Prevention ; Accidental Falls ; Caregivers ; Child ; Education* ; Hospitals, General ; Humans ; Inpatients* ; Pediatrics

PURPOSE: The purpose of this study was to investigate factors associated with suspicious developmental delay in infants and early childhood. METHODS: Participants were 133 infants, aged from birth to 6 years old and their mothers, who were being seen at 16 Public health centers in B city. Korean Denver II was used to test infant development. chi2-test, Fisher's exact test and multiple logistic regression were used with SPSS 19.0 to analyze data. RESULTS: Of participant infants, 7.5% were below the 3rd percentile for the weight percentile, 8.4% is a weight curve that crosses more than 2 percentile lines on the growth charts after previous achievement, and 9.8% had suspicious developmental delay according to Korean Denver II. Further the predictive factors related to suspicious development delay in the children were decrease of weight percentile (Odds Ratio [OR]=6.69, Confidence Interval [CI])=1.22-36.45), low economic state (OR=6.26, CI=1.50-26.00), and developmental delay perceived by their mothers (OR=4.99, CI=1.24-20.06). CONCLUSION: It is necessary to build a government level system to follow management of development of infants and children from the time of birth. Especially, it is necessary to develop a program for children in low income families.
Achievement ; Aged ; Child ; Child Development ; Growth Charts ; Humans ; Infant ; Logistic Models ; Mothers ; Parturition ; Public Health

No abstract available.
Antibodies* ; Immunoglobulin G* ; Immunoglobulin M*