1.Change of Quality of Life after Melasma Treatment.
Hong Kyu KANG ; Jin Ok BAEK ; Joo Young ROH ; Jong Rok LEE
Korean Journal of Dermatology 2012;50(7):579-583
BACKGROUND: Melasma is an acquired, symmetrical hypermelanosis that occurs on sun-exposed areas of the skin. It has significant emotional and psychological effects on those affected with the condition. Melasma Quality of Life Scale (MELASQOL) is a specific questionnaire to identify the most impaired areas of melasma patient's life. OBJECTIVE: Our purpose of this study is to investigate the changing of MELASQOL after the treatment of melasma. METHODS: A total of 27 volunteers with melasma were enrolled in this 8-week treatment study. The patients were instructed to apply an arbutin-containing cream,
Humans
;
Hyperpigmentation
;
Melanosis
;
Quality of Life
;
Skin
;
Surveys and Questionnaires
2.Pediculosis Capitis Misdiagnosed as Seborrheic Dermatitis.
Jihoon KIM ; Haryeong RYU ; Chulhyun YUN ; Joonseok CHOI ; Jin Ok BAEK ; Joo Young ROH ; Jong Rok LEE
Korean Journal of Dermatology 2015;53(4):337-338
No abstract available.
Dermatitis, Seborrheic*
;
Lice Infestations*
3.Pediculosis Capitis Misdiagnosed as Seborrheic Dermatitis.
Jihoon KIM ; Haryeong RYU ; Chulhyun YUN ; Joonseok CHOI ; Jin Ok BAEK ; Joo Young ROH ; Jong Rok LEE
Korean Journal of Dermatology 2015;53(4):337-338
No abstract available.
Dermatitis, Seborrheic*
;
Lice Infestations*
4.Functional Differences of the Lymphocytes in Nasal Polyps between Allergic and Non-Allergic Patients.
Yeon Gi KIM ; Sung Hoon BAEK ; Jin Bok PARK ; Hyun Joo JOO ; Jong Ok KIM ; Chong Ae KIM
Journal of Rhinology 1998;5(2):138-141
Lymphocytes can produce various kinds of cytokines which are responsible for the development of the infectious and allergic inflammation. We focused on the role of the lymphocyte in the pathogenesis of the nasal polyp. This study was designed to evaluate the functional differences of the lymphocytes between allergic and non-allergic polyp. Lymphocytes were obtained from peripheral blood and tissues of polyp in 12 patients with non-allergic polyp, 7 patients with allergic polyp and 5 normal subjects as control. Cytokines were measured with ELISA from each group of lymphocytes after stimulation with Concanavalin A (Con A). We compared the production of interleukin (IL)-2, IL-4, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma between the non-allergic and allergic groups. The levels of IL-4 and IL-6 from polyp tissue lymphocytes were higher in allergic group, while those of IL-2 and IFN-gamma were higher in non-allergic group. The levels of IL-4, IL-6 and TNF-alpha from peripheral blood lymphocytes were higher in allergic group, and IFN-gamma was higher in non-allergic group. These results suggest that cytokine productivity of the polyp tissue lymphocytes appear to be parallel to that of the peripheral blood lymphocytes in each group and shows distinct pattern of ytokine production between two groups.
Concanavalin A
;
Cytokines
;
Efficiency
;
Enzyme-Linked Immunosorbent Assay
;
Humans
;
Hypersensitivity
;
Inflammation
;
Interferons
;
Interleukin-2
;
Interleukin-4
;
Interleukin-6
;
Interleukins
;
Lymphocytes*
;
Nasal Polyps*
;
Polyps
;
Tumor Necrosis Factor-alpha
5.Cheilitis Glandularis Limited to the Upper Lip.
Jeong Hwan YUN ; Ji Hoon KIM ; Joon Seok CHOI ; Hong Kyu KANG ; Jin Ok BAEK ; Joo Young ROH ; Jong Rok LEE
Korean Journal of Dermatology 2012;50(7):652-653
No abstract available.
Cheilitis
;
Lip
;
Sialadenitis
6.Acrokeratosis Paraneoplastica with Adenocarcinoma of the Colon Treated with Topical Tretinoin.
Jin Ok BAEK ; Hye Young LEE ; Jong Rok LEE ; Joo Young ROH
Annals of Dermatology 2008;20(4):216-220
Acrokeratosis paraneoplastica, or Bazex syndrome, is one of the paraneoplastic syndromes. The characteristic skin lesions include palmoplantar keratoderma, psoriasiform skin lesions, hyperpigmentation, and nail dystrophy. The most common associated neoplasms are squamous cell carcinoma of the upper respiratory tract and other kinds of tumors with cervical lymph node metastasis. A 63-year-old woman presented with an 11 month history of hyperkeratotic lesions on the palms and soles. Ten months before she had been diagnosed with adenocarcinoma of the colon and undergone a left hemicolectomy. We report a case of acrokeratosis paraneoplastica associated with colon cancer which persisted after removal of the primary cancer, but resolved with topical tretinoin treatment.
Adenocarcinoma
;
Carcinoma, Basal Cell
;
Carcinoma, Squamous Cell
;
Colon
;
Colonic Neoplasms
;
Female
;
Histiocytoma, Benign Fibrous
;
Humans
;
Hyperpigmentation
;
Hypotrichosis
;
Keratoderma, Palmoplantar
;
Lymph Nodes
;
Middle Aged
;
Nails
;
Neoplasm Metastasis
;
Paraneoplastic Syndromes
;
Respiratory System
;
Skin
;
Skin Neoplasms
;
Tretinoin
7.A Case of Cellulitis Associated with Coral Injury.
So Young NA ; Hye Young LEE ; Jin Ok BAEK ; Joo Young ROH ; Jong Rok LEE
Annals of Dermatology 2008;20(4):212-215
Corals are the marine organism that belongs to the phylum Cnidaria, and are one of the common causes of superficial injury in the marine environment. In addition to acute reactions such as burning or stinging pain and erythema, coral injuries may present with complications such as foreign body reactions, bacterial infections, and/or localized eczematous reactions. A 23-year-old male presented with an erythematous edematous tender patch with centrally grouped vesicles on the left ankle; the injury had occurred during skin-scuba diving 2 days before. A biopsy of the lesion treated with hematoxylin-eosin stain showed epidermal necrosis with subepidermal blisters and neutrophilic panniculitis. Herein we report a case of cellulitis caused by the nematocyst stings of corals.
Anthozoa
;
Aquatic Organisms
;
Bacterial Infections
;
Biopsy
;
Bites and Stings
;
Blister
;
Burns
;
Cellulitis
;
Cnidaria
;
Diving
;
Erythema
;
Foreign Bodies
;
Humans
;
Male
;
Necrosis
;
Nematocyst
;
Neutrophils
;
Panniculitis
;
Young Adult
8.Two Cases of Milia-like Idiopathic Calcinosis Cutis Occurred in Infants.
Ji Hoon KIM ; Jeong Soo KIM ; Ha Ryeong RYU ; Chul Hyun YUN ; Jong Rok LEE ; Joo Young ROH ; Sang Ho LEE ; Jin Ok BAEK
Korean Journal of Dermatology 2016;54(4):310-311
No abstract available.
Calcinosis*
;
Humans
;
Infant*
9.Effect of Dendritic Cell Based Cancer Vaccine Using Allogeneic Tumor Cell Lysate in Melanoma Pulmonary Metastasis Model.
Young Joon LEE ; Myung Joo KIM ; So Hee IN ; Ok Mi CHOI ; Soyoung BAEK ; Young Do KWON ; Hyunah LEE
Immune Network 2005;5(3):163-171
BACKGROUND: To perform the successful dendritic cell-based cancer immunotherapy one of the main issues to be solved is the source of antigen for DC pulsing. Limitations occur by using auto-tumor lysate due to the difficulties obtaining enough tumor tissue(s) quantitatively as well as qualitatively. In this study the possibility of allogeneic tumor cell lysate as a DC pulsing antigen has been tested in mouse melanoma pulmonary metastasis model. METHODS: B16F10 melanoma cells (1x10(5)/mouse) were inoculated intravenously into the C57BL/6 mouse. Therapeutic DCs were cultured from the bone marrow myeloid lineage cells with GM-CSF and IL-4 (1,000 U/ml each) for 7 days and pulsed with lysate of either autologous B16F10 (B-DC), allogeneic K1735 (C3H/He origin; K-DC) or CloneM3 (DBA2 origin; C-DC) melanoma cells for 18 hrs. Pulsed-DCs (1x10(6)/mouse)[CGP1] were injected i.p. twice with one week interval starting from the day 1 after tumor cell inoculation. RESULTS: Without observable toxicity, allogeneic tumor cell lysate pulsed-DC induced the significantly better anti-tumor response (tumor scale: 2.7+/-0.3, 0.7+/-0.3 and 0.3+/-0.2 for saline, B-DC and C-DC treated group, respectively). Along with increased tumor specific lymphocyte proliferations, induction of IFN-gamma secretion against both auto- and allo-tumor cell lysates was observed from the DC treated mice. (w/B16F10-lysate: 44.97+/-10.31, 1787.94+/-131.18, 1257.15+/-48.27, w/CloneM3 lysate: 0, 1591.13+/-1.83, 1460.47+/-86.05 pg/ml for saline, B-DC and C-DC treated group, respectively) Natural killer cell activity was also increased in the mice treated with tumor cell lysate pulsed-DC (8.9+/-[CGP2]0.1, 11.6+/-0.8 and 12.6+/-0.7% specific NK activity for saline, B-DC and C-DC treated group, respectively). CONCLUSION: Conclusively, promising data were obtained that allogeneic-tumor cell lysate can be used as a tumor antigen for DC-based cancer immunotherapy.
Animals
;
Bone Marrow
;
Dendritic Cells*
;
Granulocyte-Macrophage Colony-Stimulating Factor
;
Immunotherapy
;
Interleukin-4
;
Killer Cells, Natural
;
Lymphocytes
;
Melanoma*
;
Mice
;
Neoplasm Metastasis*
10.The Effect of Oral Famciclovir in Pityriasis Rosea.
Jin Ok BAEK ; Min KIM ; Joo Young ROH ; Jong Rok LEE ; Ai Young LEE
Korean Journal of Dermatology 2007;45(12):1240-1245
BACKGROUND: Pityriasis rosea is a common, acute self-limiting papulosquamous disorder in which many studies suggest viral causative factors in its pathogenesis. Recently, the link between pityriasis rosea and the reactivation of human herpes virus-6 (HHV-6) and HHV-7 infection has been suggested. This evidence suggests that targetting HHV-6 or HHV-7 may be an effective treatment for pityriasis rosea. OBJECTIVE: We treated pityriasis rosea patients with oral famciclovir to investigate the effect of oral famciclovir in pityriasis rosea. METHODS: A case group of seventeen patients with pityriasis rosea were treated with oral famciclovir (250 mg 3 times daily for 7 days). Clinical evaluation at 0, 1 & 2 weeks was undertaken. A skin biopsy and polymerase chain reaction analysis of HHV-6 from a skin specimen were performed. We analyzed 19 patients with pityriasis rosea who were treated with topical steroid and oral antihistamines retrospectively and considered them as the control group. RESULTS: On the 7th day after oral famciclovir treatment was started, pityriasis rosea had regressed completely in 3 patients (17.6%) and had regressed partially in 9 patients (52.9%). On the 14th day, 12 patients (70.6%) had achieved more than partial regression. On the 7th day, systemic symptoms had improved in all 9 patients. Clearance of skin lesions was achieved in average 7.57 days in patients who had regressed completely after 14 days' treatment. Histological examination of patients was compatible with pityriasis rosea and polymerase chain reaction analysis of HHV-6 was negative in all 8 patients. Compared with the control group, the treatment for patients in the case group seemed to have better effects, but statistical analysis failed to show any significant differences between the two groups. CONCLUSION: Famciclovir was not effective in the treatment of pityriasis rosea, but further investigation is needed.
Biopsy
;
Herpesvirus 6, Human
;
Herpesvirus 7, Human
;
Histamine Antagonists
;
Humans
;
Pityriasis Rosea*
;
Pityriasis*
;
Polymerase Chain Reaction
;
Retrospective Studies
;
Skin
;
Skin Diseases, Papulosquamous