Multiple myeloma is a primary malignant tumor of bone marrow characterized by proliferation of cells arising from primitive marrow reticulum that resemble plasma cells. This is one of the most common primary malignant neoplasm involving bone elements. Bone pain, soft tissue mass, low grade fever, anemia, neurologic symptom and renal insufficiency are the main clinical pictures. Authors present radiological and clinical findings of multiple myeloma in 10 cases of pathologically proved multiple myeloma. The results obtained are as follows; 1. In the age and sex distributions, all cases are over 45 years of age, and male to female is 7:3. 2. Clinical manifestations are bone pain, anemia, infection, weight loss, and bleeding. 3. Radiological findings are numerous punched out osteolytic lesions, generalized osteoporosis & osteolytic change, pathologic compression fractures, fracture only and osteoporosis, lytic and fractures. 4. Laboratory findings are monoclonal gammopathy in serum-electrophoresis, proteinuria, anemia, elevated uric acid in serum, Bence-Jones protein in urine and albumin/globulin ration inverse in serum protein.
Anemia ; Bone Marrow ; Female ; Fever ; Fractures, Compression ; Hemorrhage ; Humans ; Male ; Multiple Myeloma ; Neurologic Manifestations ; Osteoporosis ; Paraproteinemias ; Plasma Cells ; Proteinuria ; Renal Insufficiency ; Reticulum ; Sex Distribution ; Uric Acid ; Weight Loss

The leukemias are the most common form of childhood cancer. The same kinds of leukemia are found in childrenand in adults. Because the radiologist is involved in the initial diagnosis, the evaluation of response to therapyand demonstration of complications, it is important that he understands the clinical and radiological features ofleukemia. This report is a clinical and radiological review of 80 cases who visited to Chonnam National UniversityHospital from Jan. 1977 to June 1981. The results are summarized as follows. 1. Most prevalent group of age wasbetween 10 to 14 years old(25%) and male was affected more frequently than female with the ratio of 1.4:1. Acuteform of leukemia was 95% and acute myelocytic leukemia was more frequent than acute lymphocytic leukemia. 2.Pallor with anemic conjuctiva was the most prominent clinical manifestation of the leukemia. Fever was the mostcommon symptom in childhood leukemia and general weakness was the most common in adult leukemia. 3. Hematologicexamination revealed marked anemia(Hemoglobin level was less than 8.0gm/100ml in 65%). In 17.5% the leukocytecount was less than 5,000/cu.mm and more than 10,000/cu.mm in 65%. Platelet count was less than 50,000/cu/mm in 23.8% and between 50,000 and 150,000/cu.mm in 43.7%. 4. The abnormal findings in chest X-ray films were observedin 35%. Pneumonia(18.8%) was the most common and lymphadenopathy(17.5%), pleural effusion(12.5%), leukemicinfiltration (3.75%), pulmonary congestion and pulmonary edema(3.75%) were descending order of frequency. 5. Theabnormal findings in long bone X-ray films were observed in 75% and the bone changes were more frequent in acutelymphocytic leukemia (57.1%) than in acute myelocytic leukemia(17.9%). Metaphseal transverse radiolucent band(75.0%) was the most common and osteolytic lesion(60.7%), periosteal reaction (35.7%), osteosclerosis(7.1%) were descending order of frequency. 6. The common sites of bony changes were femur(75%), tibia(57.1%), fibular(57.1%)humerus, radius and ulna in order of frequency. 7. In 35.7% of the cases who complained of bone or joint pain withabnormal findings in long bone x-ray films, leukocyte count was less than 5,000/cu.mm.
Adult ; Arthralgia ; Diagnosis ; Estrogens, Conjugated (USP) ; Female ; Fever ; Humans ; Jeollanam-do ; Leukemia ; Leukemia, Myeloid, Acute ; Leukocyte Count ; Male ; Platelet Count ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Radius ; Thorax ; Ulna ; X-Ray Film

Osteosarcoma is a malignant tumor arising from the undifferentiated fibrous tissue of bone and one of the mostcommon pirmary malignant tumors of bone. The diagnosis of osteosarcoma is based one can be diagnosed with areasonable degree of confidence from the conbination of the lesion site, age and radiological findings. This is aclinical and radiological observation of 40 cases of osteosarcoma which were experienced at Chonnam NationalUniversity Hospital, Chosum University Hospital and Kwangju Christian Hospital from 1978 to 1981. The results wereas follows; 1. The peak incidence was in the age group from 10 to 19 years in 21 cases (52.5%). 2. In sexdistribution, male group showed slightly higer incidence than in female group with the ratio of 1.35;1. 3. Themost commonly affected site was proximal tibia(35%). The lesion was found around the knee in 65% of the studiedcases. 4. Increment of the level of serum alkaline phosphase was observed in 25 cases (62.5%), and the averagevalue of serum alkaline phosphature in these cases was 5.6 Bessay Lowry units. 5. Radiographically, osteoblastictype was 14 cases (35%), and soft tissue mass shadow with calcification was observed in 34 cases (85%). 6.Cortical destruction was observed in 30 cases (75%), and soft tissue mass shadow with calcification was observedin 34 cases (85%). 7. Solid periosteal reaction, sunburst periosteal reaction and Codman's triangle were observedin 35%, 57.5% and 22.5% respectively. 8. At the first visit, lung meatastasis was found in 5 cases (12.5%) andinguinal lymphnode metastasis in 2 cases (5%)
Diagnosis ; Female ; Gwangju ; Humans ; Incidence ; Jeollanam-do ; Knee ; Lung ; Male ; Neoplasm Metastasis ; Osteosarcoma ; Sulindac

PURPOSE: The focus of this study was on symptom management to predict quality of life among individuals with heart failure. The theoretical model was constructed based on situation-specific theory of heart failure self-care and literature review. METHODS: For participants, 241 outpatients at a university hospital were invited to the study from May 19 to July 30, 2014. Data were collected with structured questionnaires and analyzed using SPSSWIN and AMOS 20.0. RESULTS: The goodness of fit index for the hypothetical model was .93, incremental fit index, .90, and comparative fit index, .90. As the outcomes satisfied the recommended level, the hypothetical model appeared to fit the data. Seven of the eight hypotheses selected for the hypothetical model were statistically significant. The predictors of symptom management, symptom management confidence and social support together explained 32% of the variance in quality of life. The 28% of variance in symptom management was explained by symptom recognition, heart failure knowledge and symptom management confidence. The 4% of variance in symptom management confidence was explained by social support. CONCLUSION: The hypothetical model of this study was confirmed to be adequate in explaining and predicting quality of life among patients with heart failure through symptom management. Effective strategies to improve quality of life among patients with heart failure should focus on symptom management. Symptom management can be enhanced by providing educational programs, encouraging social support and confidence, consequently improving quality of life among this population.
Aged ; Female ; Health Knowledge, Attitudes, Practice ; Heart Failure/*psychology ; Humans ; Male ; Models, Theoretical ; *Quality of Life ; Self Care ; Self Concept ; Social Support ; Surveys and Questionnaires

The purpose of this study was to test psychometric properties Health-Related Hardiness Scale(HRHS) for Korean elderly. HRHS has been developed by Pollock to measure the effect of hardiness in individuals with actual health problems. Items were generated to measure dimensions based on theoretical definitions of health-related control, commitment, and challenge. In 1990, Pollcok and Duffy revised HRHS to be 34 items. In this study, 34-item HRHS(Pollock & Duffy, 1990) was translated into Korean and administered to 193 elderly involving in 95 hospitalized patients and 98 outpatients or healthy people. The subjects were 80 women and 112 men with an age range of 65 to 95 years(M=71 years) in whom 82.6% classified themselves as moderate or pretty active. Most subjects(80.2%) had education of elementary school or less. The 34-item HRHS consists of three subscales: control, commitment, and challenge, and was measured with 1(strongly disagree) to 6(strongly agree) Likert scale. The higher the score is, the higher people's hardiness. Factor analysis was performed to confirm whether the scale represents three sub-areas as suggested in the literature. Two factors were isolated, using principle components analysis. Two factor solution was accepted for the study since Pollock described the possibility of classifying sub-areas into two divisions. These two factors, commitment/challenge and control accounted for 31.9% of variance of the scale. Factor loadings were string, ranging from .41 to .77. The moderate correlation with task self-efficacy scale also supported the validity(r=.35, p<.05). The scale was found to be internally consistent, showing Cronbanch;s alpha of .90 for the total items with the range of .82 and .90 for three subscales. The findings revealed the potential applicability of HRHS to nursing intervention studies for elderly.
Aged* ; Clinical Trial ; Education ; Female ; Humans ; Clinical Trial ; Male ; Nursing ; Outpatients ; Psychometrics*

BACKGROUND: The epidermis and adnexal epithelium might express different types of keratin (K) during fetal development. OBJECTIVE: The objective is to observe the distribution of K8/18 in the skin of fetuses and to find out the distinction of expressions of K8/18 during fetal development. METHODS: Immunohistochemical analysis was applied to the skin of the scalp and sole of 42 fetuses ranging from 10 to 39 weeks of gestation. Immunohistochemical staining with monoclonal antibodies with CAM5.2 using LSAB kit against K8/18 was conducted. RESULTS: In the skin of the scalp, K8/18 was expressed in the periderm and basal layer of epidermis from the 10th week to the 31st week of fetal gestation. K8/18 was expressed in the hair germ, bulge and basal cells of fetal the infundibulum and sebaceous glands. Root sheath cells were weakly positive but matrix cells were negative. The expression of K8/18 was negative in the basal layer of the sole. Merkel cells, which are located in the basal layer and upper dermis, were positive from the 12th week of gestation. Terminal eccrine ducts and acinar cells were positive after the 20th week of gestation. CONCLUSION: K8/18 in the skin of the scalp and sole of fetuses were expressed in different ways. The expression of K8/18 in the basal cells of the sole were negative while basal cells of the epidermis of the scalp were positive transiently from the 12th to the 31st week of gestation. Early hair germ cells and bulge cells were expressed strongly in hair follicles. Terminal eccrine ducts and acini were expressed strongly in the eccrine gland. Merkel cells located in the basal layer and papillary dermis also express K8/18.
Acinar Cells ; Antibodies, Monoclonal ; Dermis ; Eccrine Glands ; Epidermis ; Epithelium ; Fetal Development ; Fetus ; Germ Cells ; Hair ; Hair Follicle ; Merkel Cells ; Molecular Weight* ; Pregnancy ; Scalp ; Sebaceous Glands ; Skin*

Traditionally umbilical vein has been used for exchange transfusion in neonates. This method is relatively safe and effective but with a few complications. So via percutaneous femoral vein catheters we tried exchange transfusions in 30 patients with neonatal hyperbilirubinemia admitted to GNUH from September 1990 to August 1992. Femoral vein catheterization succeeded in 2~3 trials, In all cases high bilirubin level was lowered by half at the end of exchange transfusion. Transient microscopic hematuria by bladder puncture occurred in one neonate. Exchange transfusion via femoral vein catheter is a sage, easy and effective method.
Bilirubin ; Catheterization* ; Catheters* ; Femoral Vein* ; Hematuria ; Humans ; Hyperbilirubinemia, Neonatal ; Infant, Newborn* ; Punctures ; Umbilical Veins* ; Urinary Bladder

No abstract available.
Clomiphene*

In this study, we investigated the anticancer activity of the fin of Thunnus Thynnus (TT ). TT was extracted with methanol (TTM ), and then further fractionated into four subfractions by using solvent partition method, affording hexane (TTMH ), methanol (TTMM ), butanol (TTMB )and aquous (TTMA )soluble fractions. We determined the cyto-toxicity of these four fractions in four kind of cancer cell lines, such as HepG2, MCF-7, B16-F10 and HT29 by MTT assay. The TTMM showed the strongest cytotoxic effect at the concentration of 150 microgram/mL, displaying 95% on the HepG2 cell lines and 82% on MCF-7 cell line. The morphological changes such as membrane shirinking and blebbing of cells were also observed by TTMM treatment in HT29 cell. In addition, we observed that quinone reductase (QR ) activity was elevated by only TTMM and TTMH treatments in HepG2 cell. QR activity was increased to around 2.0 and 1.8 times in TTMM and TTMH treated HepG2 cell at 100 microgram/mL, respectively, compared to that in control. Although further studies are needed, the present work could suggest that the fin of TT has a potential to be usable as a chemo-preventive agent against cancer.
Blister ; Cell Line ; Hep G2 Cells ; HT29 Cells ; Humans ; MCF-7 Cells ; Membranes ; Methanol ; NAD(P)H Dehydrogenase (Quinone)*

We investigated the growth inhibitory effects of Atrina pecitinata (AP) on the proliferation in human cancer cell lines in vitro. AP was extracted with methanol which was further fractionated into four diffferent types: methanol (APMM), haxane (APMH), butanol (APMB), and aquous layers (APMA). Among various partition layers, the APMM showed the strongest cytotoxic effects on all cancer cell lines which we used. In the MTT assay of AP fractions, the growth inhibitory effects was increased in proportion to its concentration. We observed quinone reductase (QR) induced effects in all fraction layers of AP on HepG2 cells. The QR induced effects of APMM on HepG2 cell at 80 microgram/mL concentration indicated 2.0 with a control value of 1.0.
Cell Line* ; Hep G2 Cells ; Humans ; Methanol ; NAD(P)H Dehydrogenase (Quinone)