No abstract available.
Humans

No abstract available.
Anemia*

No abstract available.
Child* ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma*

No abstract available.
Stents*

This study was conducted to evaluate the effect of prolonged treatment in children with chronic hepatitis B with combination of alpha-interferon and acyclovir. The study population consisted of 7 patients with chronic hepatitis B who showed histological findings compatible with chronic active hepatitis (4 cases) or chronic persistent hepatitis (3 cases) on liver biopsy and had elevated AST and ALT with positive HBsAg, HBeAg and HBV-DNA for more than 6 months. Recombinant interferon-alpha-2 was given in a dose of 3 million IU/m2 daily for 3 months with acyclovir in a dose of 15mg/Kg of body weight every 12 hours for 7 days of each month for 3 months. Then, the same dose of interferon was given thrice a week for 9 more months. One patient who had vertically transmitted hepatitis B from her mother had received only 6 months of treatment in total as she did not show any effect after 6 months of treatment. Among 6 patients who had positive HBV-DNA on entry to the study, 4 patients (66.7%) showed conversion of HBV-DNA to negative. HBeAg was converted to negative in 3 patients (42.9%). AST and ALT became normal in 6 cases but HBsAg remained positive in all cases. prolonged treatment in children with chronic hepatitis B with combination of alpha interferon and acyclovir seems to be beneficial but the proper dosage and duration of therapy need to be determined with further and controlled study.
Acyclovir* ; Biopsy ; Body Weight ; Child* ; Hepatitis B ; Hepatitis B e Antigens ; Hepatitis B Surface Antigens ; Hepatitis B, Chronic* ; Hepatitis, Chronic* ; Humans ; Interferon-alpha* ; Interferons ; Liver ; Mothers

No abstract available.

BACKGROUND: Musculoskeletal symptoms, such as pain, numbness, and ganglions on involved joints were common problems in repetitive job workers, who exposed to prolonged, repetitive use of the wrist in factory. This study was performed to compare the degree of musculoskeletal symptoms and prevalence of soft tissue mass (esp. ganglion on wrist) in repetitive job group with those of non-repetitive job group and to evaluate the association of development of ganglion and the duration of wrist use. METHODS: Study subjects were 253 workers who work on a brick manufacturing factory and they were composed of 153 non-repetitive job workers and 100 repetitive job workers. Authors conducted a questionnaire survey among workers in the factory and examined their lesions. RESULTS: There were no significant difference statistically in age, level of education and work duration in both groups. It was statistically significant that the degree of wrist use was more frequent in repetitive job group than in non-repetitive job group(P<0.01). Musculoskeletal symptoms, such as pain and numbness on affected joints were more common in repetitive job group than in non-repetitive job group. Affected side was bilateral in three joints and right only in two joints(P<0.01, P<0.05). The prevalence of ganglions in repetitive job group(6 subjects, 6.0%) was much higher statistically than that in the non-repetitive job group(2 subjects, 1.3%). In a comparison of two groups according to the existence of ganglions, no stasistically significant differences were found in age, level of education and work duration. However, duration of wrist use was statistically significant relation with development of wrist ganglions(P<0.05). The 8 subjects with ganglion on wrist all worked on manufacturing part in the factory. The duration of work ranged from two to fourteen years. The affected sides of ganglions on wrist were right in 3 cases and left in 5 cases. Size of ganglions ranged from 0.5 to 3 cm in diameter. Painful symptom in the ganglion was complained by two cases(25%) among 8 cases. CONCLUSIONS: We suggest that prolonged, repetitive activities such as carrying a brick, have a tendency to develop musculoskeletal symptoms and ganglions in the workers. Because high prevalence of ganglions in this factory seems to be an important occupational problem among repetitive job workers, further studies on the factors contributing to development of ganglions in this factory are needed.
Education ; Ganglion Cysts* ; Hypesthesia ; Joints ; Prevalence ; Wrist ; Surveys and Questionnaires

We investigated the cold reaction of fingers in cold water as a criterion of peripheral resistance to frostbite in order to obtain elementary data to improve farmers' health. Experiments were carried out on 81 farmers and 64 urbanites at 20±2°C, 55±5% RH with sitting position on the floor. The finger skin temperatures of the subjects were measured while the left middle finger of each subject was immersed in cold water or 0°C for 30 minutes and recorded once every one minute with the thermistor. We also compiled statistics on the following items: mean finger skin temperature (MST), finger skin temperature at initial rising after immersion (TFR), time for the appearance of initial rising after immersion (TTR), cold resistance index (RI), etc. The results were as follows RI was higher in farmers than in urbanites, but there was no significant difference between the two groups. In men, RI was lower in farmers than in urbanites, but there was no significant difference between the two groups. By contrast, in women, TFR and RI were significantly higher in farmers than in urbanites. MST was significantly higer in women than in men, but RI was no statistically significant difference. By age, the men in their 30's showed significantly the highest MST and the shortest TFR. RI was significantly higher in the men in their 30's than others. In women, however, the difference in RI was of no statistical significance. By region, MST was the highest in Seoul dwellers. RI was the highest in Okku dwellers, but there was no statistically significant difference among regions.
These results indicated that farmers tended to be higher than urbanites in cold resistance index.

To collect the basic data for the health management of Korean farmers, we investigated physique factors, physical fitness, and cold resistance (by digital vascular hunting reaction during finger immersion in cold water), and examined their correlations in 74 subjects. In men, the stronger the digital vascular hunting reaction was the higher the physical fitness levels. For women, however, the motility of those who showed stronger digital vascular hunting reactions appeared worse. The correlation between physique and hunting reaction appeared weak in men but in women the hunting reaction of obese subjects was stronger than that of slender subjects. Agewise, men in their 30s, 40s and 50s who were short and slim appeared to have better cold-resistance. The men in their 60s who were broad-hipped had better cold-resistance, and the relation between physical fitness and hunting reaction appeared to be negative. In contrast, the women in their 30s whose subcutaneous fat was thinner showed positive hunting reaction, but in their 40s and 50s the correlation among physique, physical fitness, and hunting reaction appeared rather weak. The body fat content in the women aged 60 to 69 was high compared to that in other age groups. Among them, those who had less fat and better physical fitness showed more favorable hunting reactions.

In clinical practice, creatinine clearance (Ccr) remains the most commonly used laboratory assessment of glomerular function despite methodological and technical problems of urine collection. Schwartz et al. in 1976, reported that an accurate estimate of glomerular filtration rate (GFR) could be obtained from the simple determinations of plasma creatinine (Per) and body length (L): GFR (ml/min/1.73m2)=kL (cm)/Per (mg/100 ml), (k=constant). The subject of this study were 81 children admitted to our pediatric department from July, 1985 to June, 1987 and they were divided into three groups; group I, from 1 to 5 years old, group II, from 6 to 10 years old, group III, from 11 to 15 years old. The results were as following: 1) Measured creatinine clearance Ccr(M), ml/min/1.73m²) were 109.73±9.97 in group I, 108.26±9.02 in group II, 96.20±4.72 in group III and 105.48±5.23 in all age group. 2) Measured k(k(M)) obtained from CcrM=k Ht/Pcr were 0.49±0.03 in group I, 0.48±0.02 in group II, 0.43±0.02 in group III, and 0.47±0.02 in all age group (Ht; height). 3) Linear equations and correlation coefficient between Ht/Pcr (x) and Ccr (y) were y=0.82x-65.63 (r=0.99) in group I, y=0.61x-23.46(r=0.72) in group II, y=0.18x+54.44 (r=0.54) in group III and y=0.58x-22.13 (r=0.81) in all age group. 4) Ccr(E) was again estimated from linear equations between Ht/Pcr and Ccr(M) and k(E) was calculated with Ht/Pcr and Ccr(E) were 0.48±0.01 in group I, 0.49±0.01 in group II, 0.43±0.01 in group III and 0.47±0.00 in all age group. 5) Consistent values of k(E) and k(M) were highly significant as 95~97.5% in group I and II, 90~95% in group III and 97.5~99% in all age group. In summary, we could estimate GFR with height, plasma creatinine and measured k(k(M)) according to the age in easy and rapid way.
Child* ; Creatinine* ; Glomerular Filtration Rate* ; Humans ; Plasma* ; Urine Specimen Collection