The 2015 Middle East respiratory syndrome (MERS) outbreak in the Republic of Korea, which started with an imported case and spread throughout the country with a total of 186 cases, revealed the vulnerabilities of the health-care system of the country. The situation was compounded by the unique health-care settings in the Republic of Korea, including crowded emergency departments and large numbers of hospital visitors seeking care at multiple hospitals. To assist with the outbreak response, the Ministry of Health and Welfare of the Republic of Korea hosted several international joint missions that provided valuable information and recommendations for MERS control and prevention of future outbreaks. This report briefly summarizes the missions’ outcomes and discusses their positive impacts.

No abstract available.
Chlorpromazine* ; Hyperpigmentation ; Pigmentation*

No abstract available.
Danazol* ; Panniculitis*

BACKGROUNDS: It is well known that intimal hyperplasia is one of the most important cause of vascular graft failure in angioplasty, autogenous venous graft and prosthetic bypass graft. Clinical trials of drugs including antiplatelet agents, anticoagulant, corticosteroid, cyclosporine and prostaglandin were not satisfactory in suppressing intimal hyperplasia. Seeding of endothelial cell also have been done for this purpose with some success. There are several reports that endovascular low dose irradiation and external beam irradiation might reduce the amount of proliferative neointima after arterial injury. METHODS: In order to evaluate the effect of external beam irradiation on intimal hyperplasia in grafted vessel, femoral artery autografts using external jugular vein were performed in dogs, and studied the morphological finding under microscope and compared intimal hyperplasia between control and radiated groups. Group I (control) was not irradiated after graft. But experimental groups were irradiated with 6 Mev electron: Group II, 800 cGy on day 1; Group III, 400 cGy on day 1 and day 4 each; and Group IV, 800 cGy on day 4. Radiation efficacy on intimal hyperplasia was histologically assessed by measuring neointimal thickness at the proximal and distal site of grafted vessel at 6 weeks after graft. RESULTS: Mean neointimal thickness in all irradiated groups were significantly lesser than control group (p<0.05) and not related with irradiating time: Group I (Control), 0.41+/-0.11 mm; Group II, 0.16+/-0.10 mm; Group III, 0.19 0.10 mm; Group IV 0.15+/-0.08 mm. There was no difference in intimal hyperplasia between proximal and distal anastomotic site of grafted vessels in both control and irradiated groups: Control, 0.42+/-0.11 mm vs 0.40+/-0.10 mm; Radiated groups, 0.17+/-0.10 mm vs 0.16+/-0.09 mm; (p>0.05). CONCLUSION: These data suggest that low dose external beam irradiation might suppress intimal hyperplasia in grafted vessel, but further study will be necessary to determine optimal dose and timing of radiation delivery, and its efficacy in long segment bypass graft.
Angioplasty ; Animals ; Autografts* ; Cyclosporine ; Dogs* ; Endothelial Cells ; Femoral Artery* ; Hyperplasia* ; Jugular Veins ; Neointima ; Platelet Aggregation Inhibitors ; Transplants

No abstract available.
Neurofibromatoses*

No abstract available.
C-Reactive Protein* ; Tocolysis*

In this study the authors examined the protein components at various stages of Clonorchis sinensis, and those of tegument and metabolite of adult Clonorchis by using SDS-polyacrylamide gel electrophoresis and immunodiffusion. The following results were obtained: The protein components of C. sinensis were gradually changed during its development. A considerable change occurred during the initial 7 days after the metacercarial infection. Two bands of protein of about 97,000 molecular weight (MW) and 178,000 MW were unique to excysted metacercaria of C. sinensis. Other 2 bands of protein of 23,000 and 25,000 MW which were absent in metacercariae, might be associated with the development of sex organs in adult. In the metabolite, some components of tegumental proteins were detected. And this tegumental protein components in metabolite seems to be the major antigenic components reacting with infected rabbit antiserum by immunodiffusion. Twenty bands of protein were detected in the isolated adult tegument. Among them 6 bands were in 97,000-65,000 MW, 3 bands in 56,000-53,000 MW and 5 bands in 37,000-30,000 MW. On the other hand, in metabolic products of adult C. sinensis, 17 bands were detected.
parasitology-helminth-trematoda ; Clonorchis sinensis ; biochemistry ; protein

For the purpose of making a comparative study of protein compositions in Ascaris suum by sexes and body parts, extracts were prepared from whole bodies, body walls, genital organs, digestive organs and body fluid, of both sexes. And electrophoretic analysis was conducted using polyacrylamide slab gel in the presence of sodium dodecyl sulfate. The results were as follows: In this study, protein bands of each part were separated in the largest number and most clearly under 8 -12 percent (10 percent) gradient gel condition. The number of bands by body parts was 43 in body walls, 51 in genital organs, 47 in digestive organs, and 34 in body fluid. When examined in terms of sex, the number of bands of whole body was 38 in females and 35 in males. The electrophoretic patterns of body wall protein were in most cases similar with those seen in digestive organs. And the band with a molecular weight of 72,900 was unique to the body wall, and the 122,000 MW band was unique to the female body wall. In genital organ extracts, large molecular weight proteins (more than 80,000) were more frequently met. The molecular weights showed some differences between the two sexes. Of the bands, those having molecular weights of 119,700, 100,500, 88,500 and 86,100 were unique to the female genital organs. On the other hand, the male genital organs showed unique bands having molecular weights of 87,100, 82,800, and 15,500. An unique band common to the genital organs of both sexes was one having 49,300 MW. In the digestive organs evenly distributed protein bands of molecular weights of l0,000-120,000 were observed. The band having 59,800 MW was unique to the digestive organs. The number of bands obtained from body fluid was comparatively small, and the number of bands having less than 30,000 MW was 7, accounting for 55 percent of the total protein amounts. The bands having 47,600 MW and 31,400 MW were unique to body fluid.
parasitology-helminth-nematoda ; Ascaris suum ; biochemistry ; protein

No abstract available.
Mucinoses*

No abstract available.
Granuloma Annulare ; Rheumatoid Nodule