1.Oncogenic Osteomalacia
Journal of Korean Society of Endocrinology 1994;9(1):1-4
No abstract available.
Osteomalacia
2.Clinical Manifestations and Perinatal Outcomes in Pregnancies with Fetal Dysplastic Kidney Disease.
Kie Suk OH ; Haeng Soo KIM ; Jeong In YANG ; Joon Hwan OH ; Seung Seop KEUM
Korean Journal of Obstetrics and Gynecology 2000;43(1):43-50
OBJECTIVE: To obtain clinically useful data regarding prenatal diagnosis, proper antepartum counseling and obstetric management in pregnancies with fetal dysplastic kidney disease. METHODS: We retrospectively reviewed 13 cases of MCDK(Multicystic dysplastic kidney) and PCDK(Polycystic dysplastic kidney), diagnosed by antenatal ultrasound and delivered from June 1994 through July 1999 at Ajou University School of Medicine, Department of Obstetrics and Gynecology, with regard to prenatal ultrasonographic findings, perinatal outcomes, maternal complications and associated fetal anomalies. RESULTS: The incidence of MCDK and PCDK was one in 1,066 and one in 2,398 births, respectively. Of the 9 cases of MCDK, one case was terminated due to severely associated anomaly, and 6 cases were delivered by spontaneous labor or pitocin induction at term, of which 1 case was delivered by pitocin induction at 36 weeks gestation due to intrauterine fetal death. Two cases were delivered by cesarean section. There were no neonatal deaths in 7 cases of MCDK and they have been followed up to date, and alive. Of the 4 cases of PCDK, 3 cases were terminated by induced abortion or induced vaginal delivery, and 1 case was delivered by cesarean section, which was combined with hypertrophic cardiomyopathy, and the baby died within 24 hours after birth. Perinatal complications consisted of small for gestational age, urinary tract infection, hydronephrosis, acute respiratory failure, acute renal failure, periventricular hemorrhage and laryngomalacia in the neonatal period. CONCLUSION: It is suggested that antenatal ultrasonography and genetic analysis to evaluate accurate diagnosis and associated anomalies should be performed to manage and councel properly the pregnancies with fetal dysplastic kidney disease.
Abortion, Induced
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Acute Kidney Injury
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Cardiomyopathy, Hypertrophic
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Cesarean Section
;
Counseling
;
Diagnosis
;
Female
;
Fetal Death
;
Gestational Age
;
Gynecology
;
Hemorrhage
;
Humans
;
Hydronephrosis
;
Incidence
;
Kidney Diseases*
;
Kidney*
;
Laryngomalacia
;
Obstetrics
;
Oxytocin
;
Parturition
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Pregnancy*
;
Prenatal Diagnosis
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Respiratory Insufficiency
;
Retrospective Studies
;
Ultrasonography
;
Urinary Tract Infections
3.Serum Interleukin-6 Concentration in Carcinoma of the Cervix.
Yong Ju LEE ; Jae Wook KIM ; Ki Seok OH ; Oh Seung YANG ; Dong Kyu KIM
Korean Journal of Gynecologic Oncology and Colposcopy 1993;4(3):1-6
Interleukin-6(IL-6) is a multifunctional cytokine, and deregulated IL-6 gene expression has been implicated as being involved in the pathogenesis of a number of diseaaes. So we measured the serum level of IL-6 to find a relationahip between uterine cervical cancer and serum IL-6 level. The serum levels of IL-6 were meesured m 54 patients adrnitted to the Severance hospital, from August, 1992 to February, 1993, of whom 27 patients were diagnosed as invasive cancer of cervix, 17 as CIN, and also utilizing 10 patiente diagnosed as uterine myoma as a control group for matched age and parity. The average serum level of IL-6 in invasive cancer, CIN, and uterine myoma were respectively 30.33pg/ml, 37.27pg/ml, and 12.45pg Jml. In 22% af cervical cancer patients (6 of 27), and 27% of CIN patients (4 of 17) studied blood levels of II-6 were detected whereas only 10% of uterine myoma (1 of 10) shorved the same result. However, the difference does not seem to be statistically significant, There was no statistically significant difference among any of the groups, and age and stage did not show any significant cmrelation, and the results need furt,ber investigations.
Cervix Uteri*
;
Female
;
Gene Expression
;
Humans
;
Interleukin-6*
;
Leiomyoma
;
Parity
;
Uterine Cervical Neoplasms
4.A case of gastric glomus tumor.
Seung Woo LEE ; Se Jeong OH ; Seung Mahn PARK ; Young Ha KIM ; Yang Keun PARK ; Myung Gyu CHOI
Journal of the Korean Surgical Society 1993;45(5):735-740
No abstract available.
Glomus Tumor*
5.A case of double compartment hydrocephalus.
Eun Kyung OH ; Hae Young LEE ; Jae Seung YANG ; Chul HU ; Young Hyuk LEE
Journal of the Korean Pediatric Society 1991;34(9):1305-1310
No abstract available.
Hydrocephalus*
6.Clinical Significance of Phase Analysis in Myocardial Infarction.
Hyun Seung KIM ; Je Yol OH ; Hyuck Moon KWON ; Yang Soo JANG
Korean Circulation Journal 1992;22(1):67-76
BACKGROUND: Evaluating the segmental wall motion of left ventricle is important in patients with myocardial infarction for choosing therapeutic modality and predicting prognosis. Radionuclide Multigated Angiography(MUGA) is a reliable noninvasive method for the evaluation of left ventricular performance. Methods : MUGA scan(LV ejection fraction, phase image histogram, regional wall motion) was performed and analyzed in 45 patients with myocardial infarction(31 : acute MI, 14: old MI) and 13 normal controls. RESULTS: 1) The LVEF of acute and old MI group was significantly reduced and the SDph of acute and old MI group was significantly increased as compared with that of control group(p<0.05). 2) In acute MI group, the LVEF of group without, IV Urokinase was more reduced than that of group with IV Urokinase and the SDph of group without IV Urokinase was more increased than that of group with IV Urokinase(p<0.05). As a result of wall motion scoring, the linear correlation exists between SDPh and sum of wall motion scoring(r=0.62, p<0.01). 3) In MI group, the LVEF of anterior wall MI was more reduced than that of inferior wall MI and the SDPh of anterior wall MI was more increased than that of inferior wall MI(p<0.05). 4) In acute anterior wall MI, the reverse correlation exists between LVEF and SDPh and the linear correlation exists between sum of wall motion scoring and SDPh(r=-0.73, 0.72, p<0.01). But there are no statistical significances of correlation between them in acute inferior MI(r=-0.44, 0.42, p>0.05), in old anterior MI(r=-0.65, 0.47, p>0.05) and in old inferior MI(r=-0.47, 0.46, P>0.05). CONCLUSION: These results suggest that Phase angle(SDPh) is thought to be valuable index to evaluate left ventricular function with application of other indeces in Myocardial infarction. Left ventricular function measured by SDph in acute or anterior MI is lower than old or inferior MI.
Heart Ventricles
;
Humans
;
Myocardial Infarction*
;
Prognosis
;
Urokinase-Type Plasminogen Activator
;
Ventricular Function, Left
7.Enhancement of Short-Term Memory by Methyl-6-(Phenylethynyl)-Pyridine in the BTBR T+tf/J Mouse Model of Autism Spectrum Disorder.
Haijie YANG ; Sung Oh HUH ; Jae Seung HONG
Endocrinology and Metabolism 2015;30(1):98-104
BACKGROUND: Autism spectrum disorder (ASD) encompasses a range of disorders that are characterized by social and communication deficits and repetitive behaviors. This study evaluated the effect of methyl-6-(phenylethynyl)-pyridine (MPEP), an antagonist of the mGluR5 metabotropic glutamate receptor, on memory enhancement in the BTBR T+tf/J (BTBR) mouse strain, which has been recognized as a model of ASD. METHODS: The pharmacological effects of MPEP on memory and motor coordination were assessed using the Morris water maze and rotarod tests in BTBR and C57BL/6J (B6) mice. Furthermore, we performed morphological analyses of cerebellar foliation in BTBR and B6 mice using hematoxylin and eosin staining. RESULTS: MPEP-treated BTBR mice exhibited improved learning and memory in the Morris water maze test. MPEP administration also improved motor coordination in the rotarod test. However, no significant difference was observed regarding the numbers of Purkinje cells in the cerebella of BTBR versus normal B6 mice. CONCLUSION: This study suggests that the mGluR5 antagonist MPEP has the potential to ameliorate learning and memory dysfunction and impaired motor coordination in BTBR mice. These results further suggest that the BTBR mouse model may be useful in pharmacological studies investigating drugs that could potentially alleviate cognitive dysfunction in ASD.
Animals
;
Child
;
Autism Spectrum Disorder*
;
Eosine Yellowish-(YS)
;
Hematoxylin
;
Learning
;
Maze Learning
;
Memory
;
Memory, Short-Term*
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Mice*
;
Purkinje Cells
;
Receptors, Metabotropic Glutamate
;
Rotarod Performance Test
8.A Case of Sertoli Cell Tumor Presented with Sexual Precosity.
Hyun Jung CHO ; Seung YANG ; Phil Soo OH ; Jeh Hoon SHIN
Journal of Korean Society of Pediatric Endocrinology 2004;9(1):86-90
Some sexual differentiation disorders are associated with gonadal neoplasia and increased incidence of testicular tumors has been discribed in the patients with, XY gonadal dysgenesis. The incidence of testicular tumors in infants and children are rare, representing only 1% of all pediatric solid tumors. In general, gonadal stromal tumors are one of the most characteristic endocrine tumors of the testis, endocrine activity occurs in at least 10-20%, among them Leydig cell tumors and Sertoli cell tumors are clinically important. Although the exact pathogenesis is unknown, endocrine activity due to estrogen secretion can be manifested clinically with gynecomastia or precocious puberty. We experienced and reported a child who visited for sexual precocity and had XY gonadal dysgenesis with Sertoli cell tumor.
Child
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Disorders of Sex Development
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Estrogens
;
Gonadal Dysgenesis
;
Gonads
;
Gynecomastia
;
Humans
;
Incidence
;
Infant
;
Leydig Cell Tumor
;
Male
;
Puberty, Precocious
;
Sertoli Cell Tumor*
;
Testicular Neoplasms
;
Testis
10.Changes in the Lacrimal Excretory System Depending on the Administration Mode of Brimonidine Tartrate: Spray vs. Irrigation.
Journal of the Korean Ophthalmological Society 2011;52(5):511-518
PURPOSE: To investigate the effects of 0.15% brimonidine tartrate ophthalmic solution spray on the luminal changes in the nasolacrimal excretory system. METHODS: A prospective study was performed on 52 eyes in 26 patients complaining of epiphora in both eyes. The randomly-assigned 26 test eyes (cases) received spray of the solution through the nasal cavity, and the other 26 eyes (controls) were irrigated with the same drug through the inferior calnaliculus. Dacryocystography was then performed to observe the luminal changes jn the nasolacrimal excretory system, patient symptoms and physiologic drainage functions. RESULTS: The changes in lumen width of the nasolacrimal duct (NLD) were noted, and the changes in lumen width of the lacrimal sac were not significant in either mode. The upper and middle parts of the NLD were widened more in the irrigation group, and the lower part of the NLD was widened more in the spray group. Though there was no significant difference in the physiologic drainage functions, the patients in both groups reported reduced symptoms. CONCLUSIONS: Brimonidine tartrate spray altered the width of the NLD and improved the subjective symptoms of patients. Therefore, the spray can be applied in functional NLD obstruction patients before the surgical procedure.
Drainage
;
Eye
;
Humans
;
Lacrimal Apparatus Diseases
;
Nasal Cavity
;
Nasolacrimal Duct
;
Phenobarbital
;
Prospective Studies
;
Quinoxalines
;
Brimonidine Tartrate