Pedunculated lipofibroma is a rare disorder characterized by ectopic deposits of mature adipose tissue in the dermis. It is a dorne shaped or sessile papule which occurs at any site and develops later in life. We, herein, report two cases of pedunculated lipofibroma which have developed on the chin of a 64-year-old man and the buttock of a 47-year-old woman.
Adipose Tissue ; Buttocks ; Chin ; Dermis ; Female ; Humans ; Middle Aged

No abstract available.

No abstract available.

This study was designed to investigate dental arch shapes buccally and lingually at Bracket Level of Koreans. This involved studying 63 inviduals (37 males, 26 females) with normal occlusion ranging in age from 17 to 24 years old. The landmarks were digitized and measurements and statistical analysis were performed by NEC 9801 V-M computer. The Results were as Follows: Bicanine width, Bipremolar width and Bimolar width were larger in males than in females. Buccal and lingual arch form and coordination form were obtained by NEC 9801 V-M computer. The parabolic equations which represents buccal and lingual arch form were obtained.
Dental Arch* ; Female ; Humans ; Male ; Young Adult

This study aimed to investigate the existence of GABA receptor and the mechanisms of action of GABA and diazepam of the trachealis muscle isolated from dog. Horizontal muscle strips of 2mm×15mm were prepared from canine trachea, and isometric myography in isolated muscle chamber bubbled with 95/5%-O₂/CO₂ at 36℃, at the pH of 7.4 was performed. Muscle strips contracted responding to the electrical field stimulation (ESP) by 2~20 Hz, 20 msec, monophasic square wave of 60 VDC. GABA and diazepam suppressed the EFS-induced contractions to the similar extent, significantly. (p<0.05). Bicuculline, a GABA(A) receptor antagonist blocked both GABA- and diazepam-inhibitions; but DAVA, a GABA(B) receptor antagoinst did not affect either of them. These results suggest than in the canine trachealis muscle, there may be only GABA(A) receptor, and GABA and diazepam inhibit the contractility via GABA(A) receptor.
Animals ; Bicuculline ; Diazepam ; Dogs ; gamma-Aminobutyric Acid* ; Hydrogen-Ion Concentration ; Myography ; Receptors, GABA ; Receptors, GABA-A ; Trachea

PURPOSE: Neuroendocrine (NE) cells of the prostate are considered to be involved in the pathogenesis of benign prostate hyperplasia (BPH). By a comparative analysis of NE cell density in BPH tissue of men who were either exposed to or not exposed to 5alpha-reductase inhibitor, we investigated the relationship between NE cells and BPH, and the effect of androgen deprivation on NE cells. MATERIALS AND METHODS: Prostate tissue specimens, obtained from 30 men by transurethral resection of the prostate or radical cystoprostatectomy, were used. Of the 30 patients, 10 had a prostate smaller than 25 ml (normal control), the other 20 had a prostate larger than 40ml, 10 of who had taken 5alpha-reductase inhibitor (finasteride) for 3 months before surgery (androgen blockade group), and 10 who had not (BPH group). The distribution of NE cells in the prostate was examined using the anti-chromogranin A (CgA) antibody, and the density of the CgA-positive cells was compared by an optical dissector method. Immunoblotting was performed using the neuron specific enolase (NSE) antibody. A Mann-Whitney U test was used in a statistical analysis. RESULTS: Most of the CgA-positive NE cells were localized between the acinar epithelial cells. The mean numbers of CgA-positive NE cells per acinus in the normal controls and the BPH groups were 1.67+/-0.78 and 4.45+/-2.54, respectively, and the difference was statistically significant (p<0.05). However, the mean number of CgA-positive NE cells in the androgen blockade group, was 4.93+/-2.17, which was similar to the BPH group. In a NSE immunoblotting study, a distinct band was observed in the BPH and androgen blockade groups, but the density of the band was higher in the androgen blockade group. CONCLUSIONS: Our results suggest that NE cells may be involved in the hyperplastic process of BPH. Inhibition of dihydrotestosterone, caused by the oral administration of the 5alpha-reductase inhibitor, failed to induce any significant change in the NE cells, probably due to the incomplete androgen blockade.
Administration, Oral ; Cell Count ; Dihydrotestosterone* ; Epithelial Cells ; Humans ; Hyperplasia ; Immunoblotting ; Male ; Neuroendocrine Cells* ; Phosphopyruvate Hydratase ; Prostate ; Prostatic Hyperplasia*

The effects of intraocular hypothermia on experimental proliferative vitreoretinopathy in rabbits were studied. Vitrectomy was performed for 30 minutes with irrigating balanced salt solution in rabbit eyes, and the cultured retinal pigment epithelial cells were injected into the vitreous cavity. The irrigating balanced salt solution was used at room temperature in control eyes, and was cooled to 6 degrees C in experimental eyes. Experimental eyes showed less postoperative inflammation and demonstrated less occurrence of tractional retinal detachment compared with the control eyes. In vitro, the growth of cultured human retinal pigment epithelial ceDs was studied in the conditions of different temperatures. Significant suppression of cell growth was noted at 43 degrees C and also at 4 degrees C. The cooled irrigating solution may be used during vitrectomy procedure to decrease the occurrence of proliferative vitreoretinopathy.
Cell Proliferation* ; Epithelial Cells ; Humans ; Hypothermia* ; Inflammation ; Rabbits ; Retinal Detachment ; Retinaldehyde ; Traction ; Vitrectomy ; Vitreoretinopathy, Proliferative

No abstract available.
Erythrocytes*

The complications of peripheral or posterioruveitis, such as vitreous opacity, epiretinal membrance, and tractional retinal detachment may need vitreous surgery. This study was undertaken to evaluate the efficacy of transpars plana vitrectomy in the case of epiretinal membrance or tractional retinal detachment secondary to chronic uveitis.We included 23 eyes of 21 patients, and among them there was 16 eyes of epiretinal membrance and 7 eyes of tractional retinal detachment respectively. Improvement of vision, 2 lines or more in Anellen Chart, was noted in 10 eyes(63%) for epiretinal membrance and 2 eyes(29%) for tractional retinal detachment within post-operative 1 month. Final visual acuity decrease, compared with preoperative vision, was noted in 4 eyes(25%) for epiretinal membrance and 6 eyes(86%) for tractional retinal detachment with a mean follow-up of 34 months. The most common cause of visual acuity decrease was recurrent or persistent inflammation and resultant fibrous tissue proliferation, which became obvious within post-operative 3 months.Therefore, we`re able to conclude that the main cause of postoperative visual acuity decrease is persistent intraocular inflammation and fibrous change. So it is necessary to remove posterior hyaloid membrance actively and combine with medical treatment like corticosteroid therapy in order to control the inflammation even after vitreous surgery.
Follow-Up Studies ; Humans ; Inflammation ; Retinal Detachment ; Traction ; Uveitis* ; Visual Acuity ; Vitrectomy*

Ascorbic acid, which is toxic to retinal pigment epithelial cells in vitro, can stimulate fibrotic tissue formation. This study investigated the influence of ascorbic acid on endotoxin-induced fibrosis. Experimental vitreal fibrosis was induced in the rabbit by injecting endotoxin with or without ascorbic acid into the vitreous, and compared the degree of fibrosis. Inflammation induced by 1 microgram of endotoxin first appeared on day 1, remained on day 3. On day 7, organized membrane was developed. The striking decrease in ascorbic acid occurred after the intravitreal injection of endotoxin. In a series of experiment in which ascorbic acid were used, endotoxin produced less inflammatory response compared to the control. Rabbits which were injected 1 microgram of endotoxin (with or without ascorbic acid) had shown significant vitreal fibrosis. Even though the high conentration of ascorbic acid can provide extacellular protection for the ocular tissues during ocular inflammation, It was not effective in preventing the formation of membrane.
Ascorbic Acid* ; Epithelial Cells ; Fibrosis* ; Inflammation ; Intravitreal Injections ; Membranes ; Rabbits ; Retinaldehyde ; Strikes, Employee