Background. Demographic transition is indication of population growth rates which impacted by global environmental changes and development of modern science. Last years, number of elderly people dramatically increasing in the world and this increases also showed up in Mongolia. Therefore, investigating the ageing process, risk factors for ageing and age related changes of the human body is important for diagnosing and decreasing age-related disease, improving the quality of life in elderly and healthy ageing. We aimed to investigate age related changes of antioxidant and prooxidant status among healthy Mongolian adults.Materials and Methods. 384 healthy subjects participated in this research. We measured serum level of antioxidant and prooxidant parameters in all subjects at the Functional diagnostic laboratory and Immunology laboratory of the Health Sciences University of Mongolia.Results. Serum level of malondialdehyde (MDA) that is parameter of prooxidant activity was lower in the 21-30 age groups and highest in upper 70 age groups. There was a significantly positive correlation between age and serum MDA level (r=0.665, p 0.01). Serum antioxidant parameters such as superoxide dismutase (SOD, r=-0.357, p 0.01), glutathione (GSH, r=-0.201, p 0.01) and total antioxidant activity (TAC, r=-0.256, p 0.01) has a negative correlation with age. But glutathione peroxidase (GPx, r=0.635, p 0.01) was significantly increased with age. That means the antioxidant activity is decreasing with the ageing process. Regression analyses showed that MDA, GPx, SOD, GSH, and TAC were significantly related with the ageing process.Conclusion. We concluded that the antioxidant activity is decreasing and oxidation process is increasing with age and oxidative stress is higher in healthy Mongolian adults. Furthermore, the serum lipid level is increasing from age 40and it can be the reason for arterial wall thickness.

The increasing proportions of aged persons have been accompanied in the world. NCDs are often associated with older age groups. High blood glucose levels and unhealthy diet increase the risk of or cause most NCDs. In this study we aimed to determine correlation between the older people (60<) blood glucose level and food consumption. 1563 healthy elder people participated in this research. We measured blood glucose level in all subjects at the Nursing school’s Training and Research Center of health science university of Mongolia. Ulaanbaatar city, Orkhon aimag, Khovd aimag, Khentii aimag, Bulgan aimag, Dornogovi aimag, Tov aimags represented urban areas, while the rest of aimags and soums represented rural areas. The questionnaire was used to collect data on respondent’s social-economic status, fruit and vegetable consumption, physical activity, and their causes. In order to assess the diet pattern of the surveyed population, the respondents were asked about frequency of fruit and vegetable consumption, type of oil used in food, and amount of salt consumed daily. Simple regression analysis was performed to shown that significantly positive correlations between blood glucose and salt intake (р<0.001), The other composition are no significantly changes.

Determine the pituitary thyroid gland axis function abnormalities and relate it with serum lipid level.We enrolled 313 elderly people from UB and Orkhon aimag. Serum total TSH, T3, T4 hormones, low –density lipoprotein, high-density lipoprotein, total cholesterol and triglyceride level were defined by ELISA and fully automatic analyzer. All analyses were conducted with the use of SPSS 19.0, MS Excel 2007 program in which mean variables, One way Anova test and bivariate correlations are included.A total of 313 elder subjects, male 29.4%, female 70.6% and mean age was 71.8±9.8. Pituitary thyroid hormone abnormalities were detected mostly in females (p=0.027), thyroid hormone decrease was noticed in 70-79 age. In all groups serum triglyceride level as in normal range but it was significantly high (p=0.027) in hypothyroid group. Triglyceride level was negatively correlated with total T4 (p<0.01), positively correlated with T3 (p<0.01).Thyroid hormone decrease increases serum lipid especially triglyceride level. Furthermore it increases atherosclerosis risk factor to elderly people thus affects the quality of life.

Atherogenic dyslipidemia comprises a triad of increased blood concentrations of small, dense low density lipoprotein (LDL) particles, decreased high-density lipoprotein (HDL) particles, and increased triglycerides. A typical feature of obesity, the metabolic syndrome, atherogenic dyslipidemia has emerged as an important risk factor for cardiovascular disease. We have determined levels of serum lipid profiles in 1861 older people who lives 5 regions in Mongolia. The concentrations of total cholesterol, triglycerides and high density lipoprotein cholesterol (HDL-C) were measured using a biochemical reagents by biochemical fully automated analyzer. The levels of LDL-C were calculated by the Friedewald equation. Overall prevalence of dyslipidemia was 4.3% in men and 3.0% in women. Logistic regression showed that Odds ratio of the atherogenic dyslipidemia was OR=1.3, p=0.001 (CI 95% 0.93-2.47) for body mass index, OR=1.6, p=0.02 (CI 95% 1.0-2.88) for waist circumference, OR=1.76, p=0.03 (CI 95% 1.12-3.54) for waist hip ratio. Odds ratio of the atherogenic dyslipidemia was OR=0.98, p=0.001 (CI 95% 0.34-1.05) for gender and OR=1.0 p=0.001 (CI 95% 0.65-1.03) for age. Overall, 3.3% of older people had atherogenic dyslipidemia and 4.3% of men and 3.0% of women had atherogenic dyslipidemia. An increase of physical parameters are getting a risk factor of atherogenic dyslipidemia.

As the proportion of aged population has been increasing worldwide by the rapid development of socio-economy, health science, and educational level that affect the policy against health service and social welfare, one of the urgent issues of Mongolian society and medical science facing is to develop healthy aging process and prevention of pathological aging. As we know, healthy aging process depends upon several factors such as heritage, biological and physiological internal factors, living condition, climate, geography, socio-economy, nutrition, drinking water, lifestyle etc,. Thus, the development of healthy aging and its influential factors is an immediate issue of Mongolian medicine and society.A cross-sectional regression analysis has been used to measure socioeconomic and physiological factors for longevity. Total of 1897 participants aged less than 80 are randomly collected from Ulaanbaatar city and Mongolian 4 regions.Total of 1897 participants, less than 80 years old are involved in this study. People in an urban area are higher than those in countryside. About housing condition, 63.5% of total participants are in apartment at UB and 37.8% is in House and 44.3% in Mongolian Ger. Estimating participant’s income, 25% of relatively healthy population is below than the minimum of subsistence. However 50% of elderly people aged between 75-80 is below than minimum of subsistence. Comparing income level by age and gender income is decreased while age is increased, males are relatively higher than females. Middle income people are by 20.9%, high income people are by 57.7% less the risky than low income people. Unhealthy status is increased by 1.0% while a year of smoking, LDL by 96.5%, HDL by 94.7%, Triglycerid by 71.2%, CAVI by 91% increase risks respectively.Below indicators are more influential for the healthy aging of Mongolian elderly people as follows, education level (ρ-0.001), household income (OR=0.423, ρ<0.0001), living conditions (OR=0.326, ρ<0.05), LDL (OR=0.035, ρ<0.0001), HDL (OR=0.053, ρ<0.0001), glucose (OR=0.014, ρ<0.0001), CAVI (OR=0.090, ρ<0.0001). Higher density of healthy aged populations is found in the central region of Mongolia where altitude is 1000-1500 meters above than sea level (MASL) and temperature is between 0-6 Celsius.