Peripheral odontogenic keratocysts are rarely observed, and cases of odontogenic keratocysts of buccal soft tissues are even rarer. This study was performed to present two rare cases of odontogenic keratocysts in buccal soft tissues and review related literature.
Humans ; Odontogenic Cysts/diagnosis* ; Odontogenic Tumors

PURPOSE: To evaluate the diagnostic ability in differentiating between ameloblastoma and odontogenic keratocyst according to the imaging modalities and observers. MATERIALS AND METHODS: We evaluated thirty-six cases of ameloblastomas and forty-seven cases of odontogenic keratocysts all histologically confirmed. Six oral and maxillofacial radiologists diagnosed the lesions by 3 methods: using panoramic radiograph, using computed tomograph (CT), and using panoramic radiograph and CT. The observers were classified by 3 groups: group 1 had experienced over 10 years in oral and maxillofacial radiologic field, group 2 had experienced for 3-4 years, and group 3 was in the process of residentship. After over 2 weeks, the observers diagnosed them by the same methods. RESULTS: The ROC curve areas except for group 3 were the highest with interpretation using panoramic radiograph and CT, followed by interpretation using CT only, and the lowest with interpretation using panoramic radiograph only. The overall difference was not found in diagnostic ability among groups in using panoramic radiograph only, but there was difference in diagnostic ability of group 1 and 2 vs 3 in using CT only, and combination panoramic radiograph and CT. CONCLUSIONS: To differentiate between ameloblastoma and odontogenic keratocyst more accurately, the experienced oral and maxillofacial radiologist should diagnose with combination of panoramic radiograph and CT.
Ameloblastoma* ; Diagnosis, Differential* ; Odontogenic Cysts* ; ROC Curve

A cyst is cavity occuring in either hard or soft tissue with a liquid, semiliquid material, or air content. It is surrounded by a definite connective tissue wall or capsule and usually has an epithelial lining. The contained substance is a predominant feature in proportion to the size of the entire mass of tissue. It was classified as odontogenic cyst and non-odontogenic cyst in origin. The anatomic distribution, clinical features, final diagnosis, and treatment methods are discussed.
Connective Tissue ; Diagnosis ; Hospital Distribution Systems ; Odontogenic Cysts

PURPOSE: To clarify the clinical and radiologic parameters that can be used to differentiate odontogenic keratocyst and ameloblastoma MATERIALS AND METHODS: The records of 46 patients of ameloblstoma and 48 patients of odontogenic keratocyst at the Yonsei University Dental Hospital during the period of 1979 to 1995 were retrospestively reviewed. As a possible means for differentiating between the odontogenic keratocyst and ameloblastoma, the clinical parameters and the radiologic parameters were evaluated. RESULTS: In the clinical parameters, there was no significant defference in age, sex, and sign and symptoms(p>0.05).In the radiologic parameters, there was significant difference in site, shape of the lesion, and external root resorption of adjacent teeth(p<0.05). CONCLUSION: The site, shape of the lesion, and external root resorption of adjacent teeth can be the parameters to differentiate odontogenic keratocyst and ameloblastoma, but a definite differentiation of these two lesions needs a more specialized imaging modality.
Ameloblastoma* ; Diagnosis, Differential* ; Humans ; Odontogenic Cysts* ; Root Resorption ; Tooth

OBJECTIVES: Odontogenic keratocysts (OKCs) have a tendency to recur and possess an aggressive nature. the aim of the present study was to evaluate cytokeratin (CK) expression patterns as a method for the differentiation between dentigerous cysts (DCs) and OKCs, as their histomorphologic appearance are often indistinguishable. MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded tissue sections of 43 OKCs and 38 DCs were immunohistochemically analyzed with i-solution in a quantitative manner in order to evaluate the immunoreactivity of CK 10, 16 and 17. RESULTS: CK 10 expression was evident in 79.1% of OKCs but found in only 18.4% of DCs (P<0.05), and CK 10 expression was observed to occur more frequently in OKCs (mean 25.45%) than in DCs (2.19%) (P<0.05). The expression of CK 16 was evident in 79.1% of OKCs but found in only 7.9% of the DCs (P<0.05) and CK 16 expression was observed to occur more frequently in OKCs (mean 4.33%) than in the DCs (0.61%) (P<0.05). The expression of CK 17 was evident in 88.4% of OKCs but seen in only 15.7% of the DCs (P<0.05) and CK 17 expression was observed to occur more frequently in OKCs (mean 31.11%) than in the DCs (2.37%) (P<0.05). CONCLUSION: The immunohistochemical detection of CK 10, 16 and 17 can be utilized as a valuable biomarker for use in distinguishing between OKCs and DCs, which have clinically significant differential diagnoses.
Biomarkers ; Dentigerous Cyst ; Diagnosis, Differential ; Imines ; Keratins ; Odontogenic Cysts ; Thiazines

odontogenic cysts that the diagnosis may only become evident when the entire specimen is available for pathologic examination.Vickers and Gorin represented the early histological characteristics of ameloblastic change, and Robinson et al. described a distinct variant of ameloblastomas in which the response to enucleation was good, showing a low recurrent rate. We report a case of two identical featured radiolucent lesions on the periapical region of the left mandible. The lesions were thought to be periapical cysts clinically, but diagnosed as unicystic ameloblastoma based on their histologic findings.]]>
Ameloblastoma ; Ameloblasts ; Diagnosis ; Mandible ; Odontogenic Cysts ; Radicular Cyst

PURPOSE: 1. Retrospectively evaluate the accuracy of tentative diagnosis or impression from the clinico-radiographic materials of jaw lesions which showed mixed lesions associated with teeth. 2. To observe the diagnostic importance of the calcified part of the lesions which appear as radiopaque areas. MATERIALS AND METHODS: 14 cases of jaw lesions which showed mixed lesions associated with teeth were reviewed. These lesions were mostly diagnosed as adenomatoid odontogenic tumors (6 cases) or calcifying odontogenic cysts with (4 cases) or without odontomas (4 cases). The calcified elements of the lesions which demonstrated various sizes and patterns of radiopaque shadows resembled odontoid tissues in some cases but could not be defined in some other cases radiographically. RESULTS: The final histopathologic diagnosis confirmed adenomatoid odontogenic tumors in 4 of the 6 cases. The remaining 2 cases turned out to be odontoma and ameloblastic fibroodontoma. The 4 cases of calcifying odontogenic cysts with odontomas were correct in 3 cases but remaining 1 case was just odontoma. The 4 cases of calcifying odontogenic cysts were proved to be odontogenic keratocyst, calcified peripheral fibroma, unicystic ameloblastoma and squamous cell carcinoma. CONCLUSION: The diagnostic accuracy of the adenomatoid odontogenic tumors and calcifying odontogenic cysts were high when the lesions show typical appearance. The calcifications which show radiopaque areas could be odontomas or dystrophic calficifations or remnants of bone fragments from resorption.
Ameloblastoma ; Ameloblasts ; Carcinoma, Squamous Cell ; Diagnosis ; Fibroma ; Jaw* ; Odontogenic Cyst, Calcifying ; Odontogenic Cysts ; Odontogenic Tumors ; Odontoma ; Retrospective Studies ; Tooth*

Odontogenic keratocyst is one of the jaw cysts which have high recurrence rate and aggressive behavior. The radiographic findings and clinical symptoms of this disease are similar with other jaw cyst. So the final diagnosis requires the histopathologic confirmation and the patient should be examined periodically due to recurrence rate of this disease. This was the case of odontogenic keratocyst including a tooth which is in the left maxillary sinus.We thought it was a dentigerous cyst including a tooth preoperatively. The lesion was enucleated with yellow cheese-like material and histopathologic findings revealed abundant keratinizing debris,lining epithelium characterized by palisaded basal layer, orthokeratosis, and multifocal parakeratosis.]]>
Dentigerous Cyst ; Diagnosis ; Epithelium ; Humans ; Jaw Cysts ; Maxillary Sinus ; Odontogenic Cysts ; Parakeratosis ; Recurrence ; Tooth

This review article aimed to introduce a category of jaw lesions associated with impacted tooth. General search engines and specialized databases such as Google Scholar, PubMed, PubMed Central, MedLine Plus, Science Direct, Scopus, and well-recognized textbooks were used to find relevant studies using keywords such as "jaw lesion", "jaw disease", "impacted tooth", and "unerupted tooth". More than 250 articles were found, of which approximately 80 were broadly relevant to the topic. We ultimately included 47 articles that were closely related to the topic of interest. When the relevant data were compiled, the following 10 lesions were identified as having a relationship with impacted tooth: dentigerous cysts, calcifying odontogenic cysts, unicystic (mural) ameloblastomas, ameloblastomas, ameloblastic fibromas, adenomatoid odontogenic tumors, keratocystic odontogenic tumors, calcifying epithelial odontogenic tumors, ameloblastic fibro-odontomas, and odontomas. When clinicians encounter a lesion associated with an impacted tooth, they should first consider these entities in the differential diagnosis. This will help dental practitioners make more accurate diagnoses and develop better treatment plans based on patients' radiographs.
Ameloblastoma ; Ameloblasts ; Dentigerous Cyst ; Diagnosis ; Diagnosis, Differential ; Fibroma ; Jaw* ; Odontogenic Cyst, Calcifying ; Odontogenic Cysts ; Odontogenic Tumors ; Odontoma ; Radiography ; Search Engine ; Tooth Diseases ; Tooth, Impacted*

Gorlin-Goltz syndrome is an autosomal dominant disorder principally characterized by cutaneous basal cell carcinomas, multiple keratocystic odontogenic tumors, and skeletal anomalies. This syndrome may be diagnosed early by dentist because keratocystic odontogenic tumors are usually one of the first manifestations of the syndrome. Early diagnosis and treatment are of utmost importance in reducing the severity of long term sequelae of this syndrome. This report presents a rare event of Gorlin-Goltz syndrome occurring in a 39-year-old male and his 8-year-old daughter. The clinical and investigative features of this familial disorder has been described in detail.
Adult ; Basal Cell Nevus Syndrome ; Carcinoma, Basal Cell ; Child ; Dentists ; Early Diagnosis ; Humans ; Male ; Nuclear Family ; Odontogenic Cysts ; Odontogenic Tumors