BACKGROUND: This study compared the onset of action of Rocuronium given as single bolus versus divided dosing, using Propofol as an induction agent. The intubating conditions and hemodynamic changes accompanying laryngoscopy and tracheal intubation were assessed following the induction techniques. METHODS: Forty ASA I and II patients who underwent elective surgical procedures under general endotracheal anesthesia, aged 15 to 65 years old and categorized under Mallampati classifications I and II were included. They were randomly assigned to two groups. For Group A intubation sequence was Rocuronium 0.6 mg./kg., Propofol 2 mgs./kg., then 5 m1s. of plain isotonic solution. Group B sequence was: Rocuronium 0.4 mg./kg., Propofol 2 mgs./kg., then Rocuronium 0.2 mg./kg. Single twitch stimulation and train-of-four were used to monitor the onset time and intubation time. Statistical analysis was done by descriptive statistics and paired students T-test with a P-value0.05 considered significant RESULTS: Onset time and intubation time for the group given a divide dose of Rocuronium were shorter. No significant change in mean arterial pressures was seen in both groups, although there was an increase in cardiac rate for the group given a single bolus. CONCLUSION: The combination of Propofol and Rocuronium in divided dose is ideal for rapid sequence intubation.
Human ; Aged ; Middle Aged ; Adult ; Young Adult ; Adolescent ; HEMODYNAMICS ; LARYNGOSCOPY ; INTUBATION ; TRACHEAL, ANESTHESIA ; ROCURONIUM ; PROPOFOL