After 2 months, more patients in the cyclosporine group had a complete or partial remission in response to the treatment than did patients in the prednison group (53,85% and 7,69%; P<0,05), after 3 months this ratio is 69,23% and 16,67%; P<0,01. This difference was confirmed at 6 months 91,66% and 60%; P<0,05), after 12 months: 100% and 50% P>0,05. Hb concentration > 90g/l is 81,8% granulocyte counts >1,56G/l is 72,72%, platelet counts >100G/l is only 36,36%. 2 patients with responses in the cyclosponrine group relapsed after 24 months of treatment. Survival rate of patients in the cyclosporine group is 15/16 (93,57%) and in the prednison group is 6/15 (40%), P<0,05. Conclusion: Immunosuppressive treatment of aplastic anemia with cyclosponrine appears to be more effective than prednison and may represents a treatment of choice for patients with idiopathic aplastic anemia who are not eligible for bone marrow transplantation.
Bone Marrow Diseases ; Therapeutics ; Cyclosporine ; Hospitals

From 11/95 to 11/97 we treated 27 patients with idiopathic aplastic anemia in which 13 treated with idiopathic aplastic anemia in which 13 treated with prednisolon and 14 cases with prednisolon. The results showed that the number of WBC, neutrophils and platelets have not increased in the group treated with cyclosporin A in the course of three months treatment. The group treated with cyclosporin A gave better than the results in comparison with group treated with prednisonlon after one month of treatment.
Bone Marrow Diseases ; Therapeutics ; Cyclosporine ; Blood Platelets

From 11/1995 to 4/1999 we treated by prednisone for 15 patients and CsA for 16 ones with idiopathic aplastic anemia. Results:- Prednison did not change significantly TCD3, TCD4 and TCD8 colony count comparing with pre-treatment (P>0.05).- CsA decreased clearly TCD3 colony count after 1st, 6th month (P<0,05). However, TCD4 colony count decreased not significantly (P>0.05). Conclusions: CsA has more suppressive effect on T-cell colonies, mainly TCDz3 and TCD8 than Prednisone and therefore it may be chosen to treat patients with idiopathic aplastic anemia without indication for bone marrow transplantation.
Anemia, Aplastic ; therapy ; blood ; therapeutics ; cyclosporine

Background: Esophageal cancer is a common disease at Digestive Surgery Department of Binh Dan hospital. Surgical treatment is still a main procedure. Objectives: Study on a less invasive surgical technique in esophagectomy with supported thoracoscopy to provide a new esophageal cancer treatment. Subjects and method: Application on a new technique via thoracoscopy to esophagectomy totally in 6 patients (1 female, 5 males), aged 60 years on average, treated in Digestive Surgery Department of Binh Dan hospital from March 2006 to June 2006. Results: The average surgical time was 260 minutes. There was no event during operation. Postoperative complications included: 1 patient had to stitch abdominal wall after operative 7 days, 3 patients with pneumonia after successful operation, 2 patients with right pneumothorax, having to put siphonage. There was one case of death without related to operative technique. Conclusion: Esophagectomy is major operation that can be conducted via open surgery or laparoscopic surgery. Although small case studies, researchers found that laparoscopic surgery is a feasible technique, can be performed safely if the surgeons having experience in open surgery and good skills on laparoscopic surgery. However, thoracoscopic esophagectomy can only be considered as a surgical method, without an alternative method to traditional open surgery.
Esophagectomy ; Esophageal Neoplasms/surgery ; Thoracoscopy ;