1.Angioedema-like facial swelling as a first manifestation of systemic lupus erythematosus.
O Yeong KWON ; Chang Hee SEO ; Sung Taek JUNG ; Dong Ho NAHM ; Hae Sim PARK
Journal of Asthma, Allergy and Clinical Immunology 1998;18(1):90-95
Angioedma is a group of disorders with multifactorial etiology but a similar clinical expression, is characterized by swelling of subcutaneous or submucosal tissue. Systemic lupus erythematosus(SLE) is a chronic multi-systemtic disease characterized by inflammation and tissue damage resulting from deposition of auto-antibodies and immune complex. We experienced a case of angioedema which was the first manifestation of SLE in 24-year-old female patient. She had suffered from severe facial edema and multiple lymphadenopathy for six months and she also had pleural effusion, positive anti-nuclear and anti-DNA antibody test. Marked decrease of C3 and C4 levels was noted with normal antigenic level, and activity of Cl esterase inhibitor. The angioedema was not improved with anti-hitamine agents and instead disappeared with use of corticosteroid and non-steroidal anti-inflammatory drugs. Complement levels normalized after corticosteroid treament. We report a case of SLE which initial manifestation was angioedema.
Angioedema
;
Antigen-Antibody Complex
;
Complement System Proteins
;
Edema
;
Female
;
Humans
;
Inflammation
;
Lupus Erythematosus, Systemic*
;
Lymphatic Diseases
;
Pleural Effusion
;
Young Adult
2.A Case of Incus Dislocation into the External Auditory Canal after Head Trauma.
Jae Bum SEO ; Ki Sik KIM ; O Sung KWON ; Byong Kwon CHOI
Korean Journal of Otolaryngology - Head and Neck Surgery 2005;48(5):687-690
Temporal bone fracture is usually the result of blunt head injury as ossicular disruption or isolated dislocation of individual ossicles may occur after temporal bone trauma. The incus is particularly prone to displacement because of its fragile ligamentous support. We report a rare case of incus dislocation into the external auditory canal associated with an underlying temporal bone fracture.
Craniocerebral Trauma*
;
Dislocations*
;
Ear Canal*
;
Head Injuries, Closed
;
Head*
;
Incus*
;
Ligaments
;
Temporal Bone
3.Pulmonary Thromboembolism: Imaging and Interpretation.
Seo Hyun KWAK ; Yeon Joo JEONG ; Kyung Soo LEE ; O Jung KWON
Tuberculosis and Respiratory Diseases 2003;55(5):429-439
No abstract available.
Magnetic Resonance Imaging
;
Pulmonary Artery
;
Pulmonary Embolism*
;
Radionuclide Imaging
4.Creutzfeldt-jakob disease.
O Hyoun KWON ; Duk L NA ; Jung Il LEE ; Yeon Lim SUH ; Dae Won SEO ; Sang Eun KIM ; Bong Ae WIE
Journal of the Korean Neurological Association 1997;15(1):137-151
We present three neuropathologically-verified and two clinically-probable cases of Creutfeldt Jakob disease. All five had nonspecific prodromal complaints or symptoms prior to overt neurological signs and showed striking progressive neurologic deterioration, especially cognitive decline and cerebellar dysfunction. Myoclonic involuntary movements and complete decapitated states followed in one or two months. The characteristic even pathognomonic in proper clinical settings, features of electroencephalography, magnetic resonance imaging and positron emission tomography and pathologic findings are presented.
Cerebellar Diseases
;
Creutzfeldt-Jakob Syndrome*
;
Dyskinesias
;
Electroencephalography
;
Magnetic Resonance Imaging
;
Positron-Emission Tomography
;
Strikes, Employee
5.Infraoptic Course of the Anterior Cerebral Artery: Case Report.
Myong Hee SEO ; Ghi Jai LEE ; Jae Chan SHIM ; O Ki KWON ; Young Cho KOH ; Ho Kyun KIM
Journal of the Korean Radiological Society 2002;47(6):565-568
An infraoptic anterior cerebral artery (ACA) arising at a low bifurcation of the internal carotid artery is a rare anomaly, of which about 33 cases have been reported to date, often in association with cerebral aneurysms. We describe a case involving an infraoptic ACA in which a ruptured middle cerebral artery aneurysm was also present. Angiography revealed the presence of an abnormal solitary ACA, arising from the intracranial proximal internal carotid artery near the origin of the ophthalmic artery, and a contralateral middle cerebral artery aneurysm. Magnetic resonance imaging showed that the ACA passed below the ipsilateral optic nerve, anterior to the optic chiasm, to join the normally positioned anterior communicating artery above the optic chiasm.
Angiography
;
Anterior Cerebral Artery*
;
Arteries
;
Carotid Artery, Internal
;
Intracranial Aneurysm
;
Magnetic Resonance Imaging
;
Ophthalmic Artery
;
Optic Chiasm
;
Optic Nerve
6.A Case of Medullary Thyroid Carcinoma in which the Skin Metastasis was Concurrently Present and Response Occurred to Chemotherapy.
Won Je CHOI ; Yun Young LEE ; Soyon KIM ; Yun Kwon KIM ; Eun Sil KIM ; Seung O SEO ; Jae Hyun JO ; Seung Min LEE ; Hyo Jin LEE
Cancer Research and Treatment 2008;40(4):202-206
Medullary thyroid carcinoma accounts for 3% of all thyroid gland malignancies. It commonly metastasizes to liver, lung, and bone. It rarely metastasizes to skin, and only a few such cases have been documented. Cutaneous metastasis suggests a poor prognosis, with a mean survival of 7.5-19 months. The most effective treatment for skin metastasis is complete surgical removal of all local and regional lesions. The response to systemic chemotherapy is typically poor. We report a case of medullary thyroid carcinoma with cutaneous metastases, which responded to chemotherapy.
Liver
;
Lung
;
Neoplasm Metastasis
;
Prognosis
;
Skin
;
Thyroid Gland
;
Thyroid Neoplasms
7.A case of pulmonary diffuse alveolar amyloidosis localized in the lung.
Hyung Suk PARK ; Hyun Joong KIM ; Young Min KHO ; Ji Young SEO ; Man Pyo CHUNG ; O Jung KWON ; Chong H RHEE ; Yong Chul HAN
Korean Journal of Medicine 1998;55(5):956-959
Primary pulmonary diffuse alveolar amyloidosis is a rare form among the pulmonary amyloidosis. Especially in primary form diffuse alveolar type is much more rare disease. the patient was checked simple chest X-ray for the purpose of routine screening test, he had no respiratory symptoms and signs and he had no complaint of other organ symptoms, while in chest roentgenogram it was found bilateral diffuse interstitial infiltration of the lung, but any other organs which commonly involved in amyloidosis were not involved in laboratory and other specific diagnostic procedures. We report a case of pulmonry diffuse alveolar amyloidosis only localized in lung which was confirmed by transbronchial lung biopsy.
Amyloidosis*
;
Biopsy
;
Humans
;
Lung*
;
Mass Screening
;
Rare Diseases
;
Thorax
8.Herpes Simplex Virus Pneumonia in Immunocopmromised Host.
Jin Ku KIM ; Choong Hyun LEE ; Kyeong Woo KANG ; Gee Young SEO ; Man Pyo CHUNG ; Hojoong KIM ; O Jung KWON ; Chong H RHEE ; Joungho HAN
Tuberculosis and Respiratory Diseases 1999;46(1):82-88
No abstract available.
Bronchoalveolar Lavage
;
Herpes Simplex*
;
Pneumonia
;
Simplexvirus*
9.Preclinical studies for pharmacokinetics and biodistribution of Ad-stTRAIL, an adenovirus delivering secretable trimeric TRAIL for gene therapy.
Chae Young KIM ; Soon Hye PARK ; Moonsup JEONG ; O Seo KWON ; Hyounmie DOH ; Su Hyung KANG ; Paul D ROBBINS ; Byong Moon KIM ; Dai Wu SEOL ; Byung Gee KIM
Experimental & Molecular Medicine 2011;43(10):580-586
Malignant glioma is the most frequent type in brain tumors. The prognosis of this tumor has not been significantly improved for the past decades and the average survival of patients is less than one year. Thus, an effective novel therapy is urgently needed. TNF-related apoptosis inducing ligand (TRAIL), known to have tumor cell-specific killing activity, has been investigated as a novel therapeutic for cancers. We have developed Ad-stTRAIL, an adenovirus delivering secretable trimeric TRAIL for gene therapy and demonstrated the potential to treat malignant gliomas. Currently, this Ad-stTRAIL gene therapy is under phase I clinical trial for malignant gliomas. Here, we report preclinical studies for Ad-stTRAIL carried out using rats. We delivered Ad-stTRAIL intracranially and determined its pharmacokinetics and biodistribution. Most Ad-stTRAIL remained in the delivered site and the relatively low number of viral genomes was detected in the opposite site of brain and cerebrospinal fluid. Similarly, only small portion of the viral particles injected was found in the blood plasma and major organs and tissues, probably due to the brain-blood barrier. Multiple administrations did not lead to accumulation of Ad-stTRAIL at the injection site and organs. Repeated delivery of Ad-stTRAIL did not show any serious side effects. Our data indicate that intracranially delivered Ad-stTRAIL is a safe approach, demonstrating the potential as a novel therapy for treating gliomas.
Adenoviridae/genetics
;
Animals
;
Blood-Brain Barrier
;
Brain/drug effects/*metabolism/pathology
;
Brain Neoplasms/genetics/metabolism/pathology/*therapy
;
Clinical Trials, Phase I as Topic
;
DNA, Viral/metabolism
;
Disease Models, Animal
;
Drug Delivery Systems
;
Drug Evaluation, Preclinical
;
*Gene Therapy
;
Glioma/genetics/metabolism/pathology/*therapy
;
Humans
;
Liver/drug effects/metabolism/pathology
;
Protein Multimerization/genetics
;
Rats
;
Spleen/drug effects/metabolism/pathology
;
TNF-Related Apoptosis-Inducing Ligand/genetics/*pharmacokinetics
10.Preclinical studies for pharmacokinetics and biodistribution of Ad-stTRAIL, an adenovirus delivering secretable trimeric TRAIL for gene therapy.
Chae Young KIM ; Soon Hye PARK ; Moonsup JEONG ; O Seo KWON ; Hyounmie DOH ; Su Hyung KANG ; Paul D ROBBINS ; Byong Moon KIM ; Dai Wu SEOL ; Byung Gee KIM
Experimental & Molecular Medicine 2011;43(10):580-586
Malignant glioma is the most frequent type in brain tumors. The prognosis of this tumor has not been significantly improved for the past decades and the average survival of patients is less than one year. Thus, an effective novel therapy is urgently needed. TNF-related apoptosis inducing ligand (TRAIL), known to have tumor cell-specific killing activity, has been investigated as a novel therapeutic for cancers. We have developed Ad-stTRAIL, an adenovirus delivering secretable trimeric TRAIL for gene therapy and demonstrated the potential to treat malignant gliomas. Currently, this Ad-stTRAIL gene therapy is under phase I clinical trial for malignant gliomas. Here, we report preclinical studies for Ad-stTRAIL carried out using rats. We delivered Ad-stTRAIL intracranially and determined its pharmacokinetics and biodistribution. Most Ad-stTRAIL remained in the delivered site and the relatively low number of viral genomes was detected in the opposite site of brain and cerebrospinal fluid. Similarly, only small portion of the viral particles injected was found in the blood plasma and major organs and tissues, probably due to the brain-blood barrier. Multiple administrations did not lead to accumulation of Ad-stTRAIL at the injection site and organs. Repeated delivery of Ad-stTRAIL did not show any serious side effects. Our data indicate that intracranially delivered Ad-stTRAIL is a safe approach, demonstrating the potential as a novel therapy for treating gliomas.
Adenoviridae/genetics
;
Animals
;
Blood-Brain Barrier
;
Brain/drug effects/*metabolism/pathology
;
Brain Neoplasms/genetics/metabolism/pathology/*therapy
;
Clinical Trials, Phase I as Topic
;
DNA, Viral/metabolism
;
Disease Models, Animal
;
Drug Delivery Systems
;
Drug Evaluation, Preclinical
;
*Gene Therapy
;
Glioma/genetics/metabolism/pathology/*therapy
;
Humans
;
Liver/drug effects/metabolism/pathology
;
Protein Multimerization/genetics
;
Rats
;
Spleen/drug effects/metabolism/pathology
;
TNF-Related Apoptosis-Inducing Ligand/genetics/*pharmacokinetics