1.Influence of the epithelium on the contraction of guinea pig isolated tracheal smooth muscle.
O Jung KWON ; Sang Heon CHO ; In Won PARK ; Young Whan KIM ; Sung Koo HAN ; Young Soo SHIM ; Keun Youl KIM ; Yong Chul HAN
Tuberculosis and Respiratory Diseases 1991;38(1):8-15
No abstract available.
Animals
;
Epithelium*
;
Guinea Pigs*
;
Guinea*
;
Muscle, Smooth*
2.Clinical study of dark-blue pigmentation in the bronchial mucosa.
In Won PARK ; Chul Gyu YOO ; O Jung KWON ; Young Whan KIM ; Sung Koo HAN ; Young Soo SHIM ; Keun Youl KIM ; Yong Chol HAN
Tuberculosis and Respiratory Diseases 1991;38(3):280-286
No abstract available.
Mucous Membrane*
;
Pigmentation*
3.Taxonomic Position and Species Identity of the Cultivated Yeongji 'Ganoderma lucidum' in Korea.
O Chul KWON ; Young Jin PARK ; Hong Il KIM ; Won Sik KONG ; Jae Han CHO ; Chang Soo LEE
Mycobiology 2016;44(1):1-6
Ganoderma lucidum has a long history of use as a traditional medicine in Asian countries. However, the taxonomy of Ganoderma species remains controversial, since they were initially classified on the basis of their morphological characteristics. Recently, it was proposed that G. lucidum from China be renamed as G. sichuanense or G. lingzhi. In the present study, phylogenetic analysis using the internal transcribed spacer region rDNA sequences of the Ganoderma species indicated that all strains of the Korean 'G. lucidum' clustered into one group together with G. sichuanense and G. lingzhi from China. However, strains from Europe and North American, which were regarded as true G. lucidum, were positioned in a clearly different group. In addition, the average size of the basidiospores from the Korean cultivated Yeongji strains was similar to that of G. lingzhi. Based on these results, we propose that the Korean cultivated Yeongji strains of 'G. lucidum' should be renamed as G. lingzhi.
Asian Continental Ancestry Group
;
China
;
Classification
;
DNA, Ribosomal
;
Europe
;
Ganoderma
;
Humans
;
Korea*
;
Medicine, Traditional
;
Phylogeny
;
Reishi
4.Genome-Wide Identification and Characterization of Novel Laccase Genes in the White-Rot Fungus Flammulina velutipes.
Hong Il KIM ; O Chul KWON ; Won Sik KONG ; Chang Soo LEE ; Young Jin PARK
Mycobiology 2014;42(4):322-330
The aim of this study was to identify and characterize new Flammulina velutipes laccases from its whole-genome sequence. Of the 15 putative laccase genes detected in the F. velutipes genome, four new laccase genes (fvLac-1, fvLac-2, fvLac3, and fvLac-4) were found to contain four complete copper-binding regions (ten histidine residues and one cysteine residue) and four cysteine residues involved in forming disulfide bridges, fvLac-1, fvLac-2, fvLac3, and fvLac-4, encoding proteins consisting of 516, 518, 515, and 533 amino acid residues, respectively. Potential N-glycosylation sites (Asn-Xaa-Ser/Thr) were identified in the cDNA sequence of fvLac-1 (Asn-454), fvLac-2 (Asn-437 and Asn-455), fvLac-3 (Asn-111 and Asn-237), and fvLac4 (Asn-402 and Asn-457). In addition, the first 19~20 amino acid residues of these proteins were predicted to comprise signal peptides. Laccase activity assays and reverse transcription polymerase chain reaction analyses clearly reveal that CuSO4 affects the induction and the transcription level of these laccase genes.
Copper Sulfate
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Cysteine
;
DNA, Complementary
;
Flammulina*
;
Fungi*
;
Genome
;
Histidine
;
Laccase*
;
Polymerase Chain Reaction
;
Protein Sorting Signals
;
Reverse Transcription
5.Intraarterial Thrombolysis for Central Retinal Artery Occlusion.
O Ki KWON ; Chul Kyu JUNG ; Kyo Jun WHANG ; Byung Chul KIM ; Eun A JUNG ; Moon Hee HAN
Neurointervention 2008;3(2):69-74
Central retinal artery occlusion (CRAO) typically causes severe and permanent visual loss in the affected eye and vision does not recover in 90% of the patients. It is believed that it occurs by occlusion of the central retinal artery with small emboli from atherosclerotic plaque of internal cerebral artery. Various methods have been introduced to recanalize the occluded artery and remove emboli but considered to fail except thrombolytic therapy. Retina is a part of the brain so basically CRAO is corresponding to acute occlusion of intracerebral artery and retinal ischemia is to cerebral stroke. Accordingly rapid procedure within therapeutic time window, choosing appropriate drugs and doses, reducing hemorrhagic and ischemic complications associated with neurovascular intervention is very important. However, clinical significance of CRAO is much different from that of acute cerebral arterial occlusion, therefore, neurointerventionists should perform this procedure within appropriate range of safety.
Arteries
;
Brain
;
Cerebral Arteries
;
Humans
;
Ischemia
;
Plaque, Atherosclerotic
;
Retina
;
Retinal Artery Occlusion*
;
Retinal Artery*
;
Retinaldehyde
;
Stroke
;
Thrombolytic Therapy
6.Preliminary Experience of Laparoscopic Hepatectomy for Hepatocellular Carcinoma.
Gwan Chul LEE ; Choon Hyuck David KWON ; Jae Won JOH ; Jin Seok HEO ; Gum O JUNG ; Ju Ik MOON ; Jong Man KIM ; Mill Jae SHIN ; Moon Suk CHOI
Korean Journal of Hepato-Biliary-Pancreatic Surgery 2011;15(1):7-12
PURPOSE: Laparoscopic liver resection has gained much popularity in recent years, but relatively few centers have performed hepatectomies in hepatocellular carcinoma (HCC) patients due to the technical difficulties faced with underlying liver cirrhosis. We now present our early experience with laparoscopic liver resection in HCC performed in a single institution. METHODS: From October 2003 until March 2009, 39 laparoscopic liver resections were performed on HCC patients among whom 26 had underlying liver cirrhosis. RESULTS: The location of the tumor was in the left lateral section in 15, segment 5 or 6 in 20, segment 4 in 3 and caudate lobe in 1. Resection involving less than a monosegment was done in 26 and more than 2 segments in 13. Tumor size ranged from 0.8 cm to 6.6 cm (median 2.35) and the resection margin from 0.1 to 6 cm (median 1.5 cm). All patients were either stage I (29) or II (10). There was no difference between cirrhotic and non-cirrhotic patients in operation time (median 210 minutes, range 60~637), change of hematocrit value (4.8%, -1~19.6%), or hospital stay (8 days, 3~67 days). The median follow up duration was 15.1 months, and the 2-year recurrence free survival rate was 48.3%. CONCLUSION: Laparoscopic liver resection in HCC with or without underlying cirrhosis seems to be feasible with minimal morbidity, especially in well selected cases with early stage HCC.
Carcinoma, Hepatocellular
;
Fibrosis
;
Follow-Up Studies
;
Hematocrit
;
Hepatectomy
;
Humans
;
Laparoscopy
;
Length of Stay
;
Liver
;
Liver Cirrhosis
;
Recurrence
;
Survival Rate
7.Intra-Arterial Thrombolysis Using Double Devices: Mechanicomechanical or Chemicomechanical Techniques.
Hyun PARK ; Gyo Jun HWANG ; Sung Chul JIN ; Jae Seung BANG ; Chang Wan OH ; O Ki KWON
Journal of Korean Neurosurgical Society 2012;51(2):75-80
OBJECTIVE: To optimize the recanalization of acute cerebral stroke that were not effectively resolved by conventional intraarterial thrombolysis (IAT), we designed a double device technique to allow for rapid and effective reopening. In this article, we describe the feasibility and efficacy of this technique. METHODS: From January 2008 to September 2009, twenty patients with acute cerebral arterial occlusion (middle cerebral artery : n=12; internal carotid artery terminus : n=5; basilar artery : n=3) were treated by the double device technique. This technique was applied when conventional thrombolytic methods using drug, microwires, microcatheters and balloons did not result in recanalization. In the double device technique, two devices are simultaneously placed at the lesion (for example, one microcatheter and one balloon or two microcatheters). Chemicomechanical or mechanicomechanical thrombolysis was performed simultaneously using various combinations of two devices. Recanalization rates, procedural time, complications, and clinical outcomes were analyzed. RESULTS: The initial median National Institute of Health Stroke Scale (NIHSS) was 16 (range 5-26). The double device technique was applied after conventional IAT methods failed. Recanalization was achieved in 18 patients (90%). Among them, 55% (11 cases) were complete (thrombolysis in cerebral infarction 2B, 3). The median thrombolytic procedural time including the conventional technique was 135+/-83.7 minutes (range 75-427). Major symptomatic hemorrhages (neurological deterioration > or =4 points in NIHSS) developed in two patients (10%). Good long term outcomes (modified Rankin Scale < or =2 at 90 days) occurred in 25% (n=5) of the cases. Mortality within 90 days developed in two cases (10%). CONCLUSION: The double device technique is a feasible and effective technical option for large vessel occlusion refractory to conventional thrombolysis.
Basilar Artery
;
Carotid Artery, Internal
;
Cerebral Arteries
;
Cerebral Infarction
;
Glycosaminoglycans
;
Hemorrhage
;
Humans
;
Stroke
8.A case of pulmonary diffuse alveolar amyloidosis localized in the lung.
Hyung Suk PARK ; Hyun Joong KIM ; Young Min KHO ; Ji Young SEO ; Man Pyo CHUNG ; O Jung KWON ; Chong H RHEE ; Yong Chul HAN
Korean Journal of Medicine 1998;55(5):956-959
Primary pulmonary diffuse alveolar amyloidosis is a rare form among the pulmonary amyloidosis. Especially in primary form diffuse alveolar type is much more rare disease. the patient was checked simple chest X-ray for the purpose of routine screening test, he had no respiratory symptoms and signs and he had no complaint of other organ symptoms, while in chest roentgenogram it was found bilateral diffuse interstitial infiltration of the lung, but any other organs which commonly involved in amyloidosis were not involved in laboratory and other specific diagnostic procedures. We report a case of pulmonry diffuse alveolar amyloidosis only localized in lung which was confirmed by transbronchial lung biopsy.
Amyloidosis*
;
Biopsy
;
Humans
;
Lung*
;
Mass Screening
;
Rare Diseases
;
Thorax
9.A Case of Rifampicin Induced Pseudomembranous Colitis.
Jong Wook YUN ; Jung Hye HWANG ; Hyoung Suk HAM ; Han Chul LEE ; Gil Hwan ROH ; Soo Jung KANG ; Gee Young SUH ; Ho Joong KIM ; Man Pyo CHUNG ; O Jung KWON ; Chong H RHEE ; Hee Chung SON
Tuberculosis and Respiratory Diseases 2000;49(6):774-779
Pseudomembranous colitis, although uncommon, is an important complication of antibiotics that is related to a variety of deleterious effects on the gastrointestinal tract. Rifampicin is one of the 1st line agents in the treatment of tuberculosis and a large number of patients are exposed to its potential adverse effects. We report upon a patient that had diarrhea due to pseudomembranous colitis after receiving antitubeculous medication, and which was probably caused by rifampicin. A 77-year-old man was admitted with diarrhea of three weeks duration. One month previously, he suffered from left pleuritic chest pain and left pleural effusion was noticed at chest X-ray. One week prior to the onset of diarrhea, he was started on empirically isoniazid, rifampicin, ethambutol and pyrazynamide as antituberculous medication. On admission, he complained of diarrhea, left pleuritic chest pain, dyspnea and sputum. On physical examination, breathing sound was decreased in the left lower lung field and bowel sound increased. Pleural biopsy revealed chronic granulomatous infalmmation, which was compatible with tuberculosis. Sigmoidoscopy showed whitish to yellowish pseudomembrane with intervening normal mucosa, and his stool was positive for C.difficle toxin. He was diagnosed as pseudomembranous colitis and treated with oral metronidazole and vancomycin. The diarrhea did not recur after reinstitution of the anti-tuberculous medication without rifampicin. In patients with severe diarrhea receining anti-tuberculous medication, rifampicin induced pseudomembranous colitis should be excluded.
Aged
;
Anti-Bacterial Agents
;
Biopsy
;
Chest Pain
;
Clostridium difficile
;
Diarrhea
;
Dyspnea
;
Enterocolitis, Pseudomembranous*
;
Ethambutol
;
Gastrointestinal Tract
;
Humans
;
Isoniazid
;
Lung
;
Metronidazole
;
Mucous Membrane
;
Physical Examination
;
Pleural Effusion
;
Respiratory Sounds
;
Rifampin*
;
Sigmoidoscopy
;
Sputum
;
Thorax
;
Tuberculosis
;
Vancomycin
10.A Case of Cloacal Anomaly with Multiple Associated Anomalies.
Seong O MOON ; Yong Soo SEO ; Chul Jung KIM ; Ji Soo LEE ; Su Ran CHOI ; Yeon Lim SUH ; Ji Eun KWON ; Jong Hwa KIM
Korean Journal of Obstetrics and Gynecology 2004;47(4):780-784
Cloacal anomaly is an extremely rare congenital malformation results from a failure in the development of the urorectal fold that separates the rectum from uterovaginal tract. It is characterized by the presence of a single duct where the gastrointestinal, genital and urinary tracts join. It presents with highly variable forms, which make it difficult to be diagnosed antenatally. We report a case of cloacal anomaly confirmed with autopsy, which was initially detected by the presence of a huge cystic fetal abdominal mass by ultrasound at a 22 weeks of gestation.
Autopsy
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Pregnancy
;
Rectum
;
Ultrasonography
;
Urinary Tract