1.BNT162B2 COVID-19 mRNA vaccination did not promote substantial anti-syncytin-1 antibody production nor mRNA transfer to breast milk in an exploratory pilot study.
Citra N Z MATTAR ; Winston KOH ; Yiqi SEOW ; Shawn HOON ; Aparna VENKATESH ; Pradip DASHRAATH ; Li Min LIM ; Judith ONG ; Rachel LEE ; Nuryanti JOHANA ; Julie S L YEO ; David CHONG ; Lay Kok TAN ; Jerry K Y CHAN ; Mahesh CHOOLANI ; Paul Anantharajah TAMBYAH
Annals of the Academy of Medicine, Singapore 2022;51(5):309-312
2.Rapid initiation of fetal therapy services with a system of learner-centred training under proctorship: the National University Hospital (Singapore) experience.
Arundhati GOSAVI ; Pradip D VIJAYAKUMAR ; Bryan Sw NG ; May-Han LOH ; Lay Geok TAN ; Nuryanti JOHANA ; Yi Wan TAN ; Dedy SANDIKIN ; Lin Lin SU ; Tuangsit WATAGANARA ; Arijit BISWAS ; Mahesh A CHOOLANI ; Citra Nz MATTAR
Singapore medical journal 2017;58(6):311-320
INTRODUCTIONManagement of complicated monochorionic twins and certain intrauterine structural anomalies is a pressing challenge in communities that still lack advanced fetal therapy. We describe our efforts to rapidly initiate selective feticide using radiofrequency ablation (RFA) and selective fetoscopic laser photocoagulation (SFLP) for twin-to-twin transfusion syndrome (TTTS), and present the latter as a potential model for aspiring fetal therapy units.
METHODSFive pregnancies with fetal complications were identified for RFA. Three pregnancies with Stage II TTTS were selected for SFLP. While RFA techniques utilising ultrasonography skills were quickly mastered, SFLP required stepwise technical learning with an overseas-based proctor, who provided real-time hands-off supervision.
RESULTSAll co-twins were live-born following selective feticide; one singleton pregnancy was lost. Fetoscopy techniques were learned in a stepwise manner and procedures were performed by a novice team of surgeons under proctorship. Dichorionisation was completed in only one patient. Five of six twins were live-born near term. One pregnancy developed twin anaemia-polycythaemia sequence, while another was complicated by co-twin demise.
DISCUSSIONProctor-supervised directed learning facilitated the rapid provision of basic fetal therapy services by our unit. While traditional apprenticeship is important for building individual expertise, this system is complementary and may benefit other small units committed to providing these services.
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