This study was carried out to investigate the response of interphase Y chromosome to some drugs and toxins by observing the rate of leukocytes showing Y-body in the peripheral blood. The interphase Y chromosomes of blood leukocytes were stained with quinacrine mustard and the animals used were rabbits, rats and guinea pies. Y-bodies of leukocytes were studied in the animals as well as in man. Changes in positive rate of Y-body in leukocytes and total leukocyte count were observed in the rabbits administered with drug or toxin. The results concerning the rate of Y-body were as follows: 1. Y-bodies were present in the blood leukocytes of the animals. However positive rates in mononuclear and polymorphonuclear leukocytes were lower in animals that in man. The positive rate of Y-body was higher in mononuclear leukocytes than in polymorphonuclear leukocytes in the animals as in man. 2. Bacterial toxins such as typhoid, D.P.T. and cholera vaccines and anticancer drugs such as busulfan and endoxan reduced the positive rates of Y-body both in mononuclear leukocytes and in polymorphonuclear leukocytes. 3. Benzene known as bone marrow toxin reduced the positive rate of Y-body in mononuclear leukocytes, but not that in polymorphonuclear leukocytes. Quinine known as general protoplasmic poison reduced the positive rate of Y-body not only in mononuclear leukocytes but also in polymorphonuclear leukocytes. 4. Antibiotics such as tetracycline and chloramphenicol and steroid hormones such as estrogen, testosterone and prednisolone had no effects on the positive rate of Y-body both in mononuclear leukocytes and in polymorphonuclear leukocytes.
Animals ; Anti-Bacterial Agents ; Bacterial Toxins ; Benzene ; Bone Marrow ; Busulfan ; Chloramphenicol ; Cholera Vaccines ; Cyclophosphamide ; Cytoplasm ; Estrogens ; Guinea ; Interphase ; Leukocyte Count ; Leukocytes* ; Leukocytes, Mononuclear ; Neutrophils ; Prednisolone ; Quinacrine Mustard ; Quinine ; Rabbits* ; Rats ; Testosterone ; Tetracycline ; Typhoid Fever ; Y Chromosome

A clinical study was made on 117 cases of benign prostatic hyperplasia admitted to the Department of Urology, Chungnam University Hospital during the period from January 1974 to August 1982. The results were summarized as follows: 1. Common symptoms were dysuria (82.1%) and urinary retention (41.0%). 2. Gross or microscopic hematuria was noticed in 48 cases (41.0%). 3. The degree of prostatic enlargement by rectal palpation was not related to the severity of symptoms. 4. Pulmonary disease (19.5%) and cardiac disease (12.8%) were frequently associated with B.P.H. 5. Treatment consisted of suprapubic of retropubic prostatectomy in 94 cases, TUR in 7 cases and cystostomy in 10 cases. 6. Postoperative complications were urinary incontinence (34%), wound problem (9.7%), delayed bleeding (8.7%), and urinary tract infection (4.8%). 7. Mean weight of removed prostatic tissue was 31.3gm.
Chungcheongnam-do ; Cystostomy ; Digital Rectal Examination ; Dysuria ; Heart Diseases ; Hematuria ; Hemorrhage ; Lung Diseases ; Postoperative Complications ; Prostatectomy ; Prostatic Hyperplasia* ; Urinary Incontinence ; Urinary Retention ; Urinary Tract Infections ; Urology ; Wounds and Injuries

The incidence of giant condyloma acuminata of the penis is extremely rare. Although they are considered clinically malignant, the real possibility of malignant changes from them are controversial even among the investigators but cannot be entirely overlooked. Therefore, attention must be focused on this fact, in our conclusion. Two cases of malignancy of the penis which have apparently been transformed from giant condyloma acuminata of the penis are herein presented with review of related literatures. Case I: Sixty nine year old male patient complained of a fungating mass on the sulcus coronaris of the penis with ulceration and bleeding from the mass. Biopsy confirmed giant condyloma acuminata and subsequently circumcision and electrocoagulation were performed. Pathological specimen taken after 4 months because of the recurrence of the mass on the same region showed squamous cell carcinoma of the penis and amputation of penis was performed. Case II: Sixty eight old male patient complained of a growing mass and pain on glans penis. This patient also underwent circumcision and electrocoagulation according to the biopsy finding of giant condyloma acuminata. But 1 year later with recurrence of the mass on the same region, the pathological finding revealed squamous cell carcinoma of penis.
Amputation ; Biopsy ; Carcinoma, Squamous Cell ; Circumcision, Male ; Electrocoagulation ; Female ; Hemorrhage ; Humans ; Incidence ; Male ; Penile Neoplasms ; Penis ; Recurrence ; Research Personnel ; Ulcer

A clinical observation was made on 30 patients of urologic surgery using the intestinal segment who had been admitted to the Department of Urology, Chungnam National University Hospital from May, 1976 to April, 1982. The results are as follows; 1. The age distribution of the most of cases were fifth and sixth decades (66.7%), and the male to female ratio was 3.3 to 1. 2. Majority of underlying diseases was bladder tumor (76.6%). The other causes were neurogenic bladder (10.0%), Vesicovaginal fistula (10.0%) and contracted bladder (3.3%). 3. Of the 30 cases of urinary diversion, 24 cases were ureteroileocutaneostomy with or without total cystectomy, 3 cases were ureterocolocutaneostomy with total cystectomy, 2 cases were ureteroileocecocutaneostomy with total cystectomy and 1 case was augmented ileocecocystoplasty. 4. Operation mortality was 10%, in which underlying diseases were bladder cancer. 5. Major complications were acute renal failure, septicemia, wound disruption, urine leakage, fecal fistula, ileus, bleeding, pneumonia and evisceration. 6. In the 23 cases of bladder cancer 21 cases were transitional cell carcinoma and 2 cases were adenocarcinoma. Most of the former were composed of stage B & C (66.7%) and grade II & III (71.4%). 7. In cases of malignant disease the overall postoperative survival rate at 1, 3 and 5 years of bladder cancer were 73.9%, 50% and 20% respectively.
Acute Kidney Injury ; Adenocarcinoma ; Age Distribution ; Carcinoma, Transitional Cell ; Chungcheongnam-do ; Cystectomy ; Female ; Fistula ; Hemorrhage ; Humans ; Ileus ; Male ; Mortality ; Pneumonia ; Sepsis ; Survival Rate ; Urinary Bladder ; Urinary Bladder Neoplasms ; Urinary Bladder, Neurogenic ; Urinary Diversion ; Urology ; Vesicovaginal Fistula ; Wounds and Injuries

This study was carried out to investigate the effect of Mycoplasma on sperm motility. It was suspected that a GUT infection due to Mycoplasma could be a possible cause of infertility. Human fresh spermatozoa from 57 healthy medical students were mixed and diluted with Mycoplasma groups. 37 specimens to T-mycoplasmas and 20 specimens to M. hominis were exposed with varying concentration from 10,000 to 1,000,000 colonies/ml of broth, respectively. Spermatozoal motility scale devised by Emmens and pH by pH paper were checked at serial time of hours in vitro. The following results were obtained. 1. There is no significant effect on sperm motility in pH change by Mycoplasma. 2. The sperm motility of control groups among pure semen, semen with normal saline and semen with broth solution were no statistically significant differences (p>0.05). 3. The statistically significant decreased sperm motility was watched in T-mycoplasmas experimental groups than that of control groups. The motility was much decreased with higher concentration of organisms (p<0.05). 4. The statistically significant decreased sperm motility was also watched in M. hominis experimental groups than that of control groups (p<0.05) The motility was much decreased with higher concentration of organisms.
Humans ; Hydrogen-Ion Concentration ; Infertility ; Mycoplasma* ; Semen ; Sperm Motility* ; Spermatozoa* ; Students, Medical ; Ureaplasma

A clinical observation was performed on 54 cases of renal stone, admitted to the Department of Urology, College of Medicine, Chungnam National University from January 1974 to August 1980. The results were as followings; 1. There were 931 inpatients which included 186 patients of urolithiasis, and renal calculi were 19.9 % of total inpatients and 29.2% of urolithiasis. 2. Male to female ratio was 1. 3:1. and two thirds of patients of renal stones were 4th and 5th decades 3. Right to left ratio wag 1:1.2. and 61. 1% of renal stones were 1.0-2.9cm in diameter. Single stone was 60% and bilaterally was 3.7%. 4. The most common symptom was flank pain, and common uninary findings were hematuria, pyuria, proteinuria and bacteriuria, and the most common organism was E. coli. 5. The operative procedures were pyelolithotomy (22 cases), anatrophicnephrolithotomy (15cases), nephrectomy (8 cases), nephrolithotomy (4 cases), extended pyelolithotomy (4 cases). 6. The longest postoperative stay and operating time were anatrophic nephrolithotomy (23. 3 days) and extended pyelolithotomy (160 minutes) respectively. In anatrophic nephrolithotomy, transfusion of whole blood was larger than in other operative procedures, and tube drain was left in extended pyelolithotomy for longest periods (7. 7 days). 7. Postoperative complications were wound infections, residual stone, urine leakage, bleeding, and pyelonephritis, The majority of the postoperative complications were noted in anatrophic nephrolithotomy.
Bacteriuria ; Chungcheongnam-do ; Female ; Flank Pain ; Hematuria ; Hemorrhage ; Humans ; Inpatients ; Kidney Calculi ; Male ; Nephrectomy ; Postoperative Complications ; Proteinuria ; Pyelonephritis ; Pyuria ; Surgical Procedures, Operative ; Urolithiasis ; Urology ; Wound Infection

A clinical observation was made on the pediatric patients (under 15 years old) who had been admitted to the Department of Urology, Chungnam National University Hospita1, during the 6 year period from March. 1974 to February, 1980. The results were as follows: 1. During the period, pediatric in-patients were 101 of 825 total urologic in-patients giving a ratio of 12.2%. 2. The proportion of male to female pediatric in-patient was 6:8:1. 3. The school children(6 to 12 years of age) were most frequently seen and giving a rate of 49.5% of pediatric in-patients. 4. The most common disease was genitourinary anomaly giving a ratio of 45.5%. The hydrocele was 22.8%, genitourinary injury 11.9%, tumor 7.9%, renal tuberculosis 2% and others 9.9% 5. The most frequently involved organ was testis and scrotum giving a ratio of 52.4%, followed by urethra 21.8%, kidney 16.8% and bladder 5.0%. 6. Among 86 of 101 cases, 103 operations were performed. The most common operation was hydrocelectomy in 23 cases. The other operations were orchiopexy in 22 cases. chordectomy in 11 cases, urethroplasty in 11 cases, nephrectomy in 7 cases, hernioplasty in 6 cases and others. 7. The most common duration of hospital stay was from 1 to 2 weeks(55.4%).
Chungcheongnam-do ; Female ; Herniorrhaphy ; Humans ; Kidney ; Length of Stay ; Male ; Nephrectomy ; Orchiopexy ; Pediatrics ; Scrotum ; Testis ; Tuberculosis, Renal ; Urethra ; Urinary Bladder ; Urology*

This study was carried out to investigate the effect of sperm motility to some bacteria which were possible cause of infertility by genitourinary tract infection. Human spermatozoa, from 42 cases of healthy medical student, were exposed to E. coli (30 cases) and Staphylococcus aureus (12 cases) varying dilutions from 10(4), 10(5), 10(6) colonies/ml of normal saline and broth solution. Spermatozoal numerical motility scale devised by Emmens was checked at the serial time of hours in Vitro. The following results were obtained: 1. Sperm motilities of control groups among pure semen, semen with normal saline, semen with broth solution and semen with broth extract contained endotoxin were no significant differences. 2. A significantly decreased sperm motility ensued in E. coli experimental groups than control group. And the more concentrated bacteria the more significant decrease of sperm motility was observed. 3. There were no significant differences between control group and experimental groups in Staphylococcus aureus.
Bacteria* ; Humans ; Infertility ; Semen ; Sperm Motility* ; Spermatozoa* ; Staphylococcus aureus ; Students, Medical

Author attempted to confirm characteristic mental symptoms of chronic prostatitis. 953 people of normal subjects, 336 patients of depressive neurotics and 183 patients of anxiety neurotics participated in this survey and each of the above groups was compared with 80 patients of chronic prostatitis respectively with intention of collection of anticipated data by means of Zung's Self-Rating Depressive Scale. Each of those groups was compared with calculated mean and standard deviation through t-test. Based on calculated means and standard deviations of each item, chronic prostatitis was compared with normal subjects, depressive neurotics and anxiety neurotics respectively by means of t-test. Each item was arranged in the order of means comparing chronic prostatitis with normal subjects, depressive neurotics and anxiety neurotics respectively. The above results are summarized as follows : 1. The degree of depressive symptom of chronic prostatitis was between that of normal subject and depressive or anxiety neurotics. 2. The psychologic symptom of chronic prostatitis patients appears to he more pronounced than that of normal subjects but physiologic symptom does not appear to be of considerable significance. 3. Depressive degree of chronic prostatitis was lower than depressive neurotics except 2 out of 20 items. 4. Comparing chronic prostatitis with anxiety neurotics, psychologic symptoms appeared to be more pronounced, but physiologic symptoms appeared to be more pronounced in anxiety neurotics. 5. There was no definitive correlation between psychological and physiological symptoms in anxiety neurotics. Chronic prostatitis patients, normal subjects, and depressive neurotics marked high in psychologic symptoms. From the above results, it could be concluded that depression of chronic prostatitis was originally similar to that of depressive neurotics and that the aspect of the quantity is of triviality.
Anxiety ; Depression ; Humans ; Intention ; Prostatitis*

144 in-patients with urinary tract tuberculosis during the period from 1965 to 1969 were observed statistically. These patients stand for 8.9% of the in-patients with male to female ratio 59.6%/40.4%. Most frequent age distribution slowed 21 to 30 years with 35.9% and next 31 to 40 years with 31.4%. And lateralization, right to left 49.3% to 41.0% and bilateral 9.7%. 47.8% of patients admitted the hospital within 6 months to 1 year after onset of symptoms, and 9.1% after 5 years. The most frequent subjective complaints was hematuria, dysuria and frequency with 41.6%, and flank pain or dullness, 30.4%. In 49.7% of cases, past history of tuberculosis was noted, of which 31.2% had pulmonary tuberculosis and 20.1% pleurisy. Tubercle bacilli were smeared positive in 49.7%. 66.7% of 102 patients showed subnormal in PSP test with criteria of 50% within 30 minutes and 70% within 2 hours. Of 113 intravenous pyelograms, functional changes revealed non-visualization 46.9%, delayed visualization 27.6%. The itemized classification based on Braasch and Emmett was similar order of frequency as original. Lattimer Grade IV and far advaced case were the most frequent in 30 retrograde pyelograms. Nephrectomy was 95% in 104 operated cases and 92 nephrectomized specimens disclosed all parenchymal tuberculous nodules, tuberculous mucosal lesion in 82%, cavities 70%, calcification 4.3%, and pyonephrosis 17%.
Age Distribution ; Classification ; Dysuria ; Female ; Flank Pain ; Hematuria ; Humans ; Male ; Nephrectomy ; Pleurisy ; Pyonephrosis ; Tuberculosis* ; Tuberculosis, Pulmonary ; Urinary Tract*