1.Determination of reactive oxygen generated from natural medicines and their antibacterial activity$
Noriko TAJIMA ; Makiko TAKASAKI ; Haruka FUKAMACHI ; Takeshi IGARASHI ; Yoshijiro NAKAJIMA ; Hidetoshi ARAKAWA
Journal of Pharmaceutical Analysis 2016;6(4):214-218
Extracts of 16 natural medicine powders (Galla chinensis, Malloti cortex, Cassiae semen, Sophorae radix, Myricae cortex, Crataegi fructus, Gambir, Mume fructus, Geranii herba, Phellodendri cortex, Coptidis rhizoma, Swertiae herba, and Cinnamomi cortex) were assayed for reactive oxygen concentrations using the per-oxyoxalate chemiluminescent detection system. High luminescence intensity was observed in Galla chinensis, Geranii herba, Malloti cortex, Myricae cortex, and Cinnamomi cortex. Additional experiments identified the reactive oxygen species as hydrogen peroxide. Galla chinensis generated 2.4 ? 10 ? 4 mol/L hydrogen peroxide from a 1 mg/mL solution. In bacterial growth tests, Galla chinensis extract had antibacterial activity against Escherichia coli, Staphylococcus aureus, Bacteroides thetaiotaomicron, Campylobacter sputorum biovar sputorum, Streptococcus salivarius thermophilus, Lactobacillus casei, and Bifidobacterium longum infantis. This antibacterial activity was de-creased by the addition of catalase. It revealed that hydrogen peroxide which Galla chinensis produced participated in antibacterial activity.
2.Remote Cardiac Rehabilitation With Wearable Devices
Atsuko NAKAYAMA ; Noriko ISHII ; Mami MANTANI ; Kazumi SAMUKAWA ; Rieko TSUNETA ; Megumi MARUKAWA ; Kayoko OHNO ; Azusa YOSHIDA ; Emiko HASEGAWA ; Junko SAKAMOTO ; Kentaro HORI ; Shinya TAKAHASHI ; Kaoruko KOMURO ; Takashi HIRUMA ; Ryo ABE ; Togo NORIMATSU ; Mai SHIMBO ; Miyu TAJIMA ; Mika NAGASAKI ; Takuya KAWAHARA ; Mamoru NANASATO ; Toshimi IKEMAGE ; Mitsuaki ISOBE
Korean Circulation Journal 2023;53(11):727-743
Although cardiac rehabilitation (CR) has been shown to improve exercise tolerance and prognosis in patients with cardiovascular diseases, there remains low participation in outpatient CR. This may be attributed to the patients’ busy schedules and difficulty in visiting the hospital due to distance, cost, avoidance of exercise, and severity of coronary disease. To overcome these challenges, many countries are exploring the possibility of remote CR. Specifically, there is increasing attention on the development of remote CR devices, which allow transmission of vital information to the hospital via a remote CR application linked to a wearable device for telemonitoring by dedicated hospital staff. In addition, remote CR programs can support return to work after hospitalization. Previous studies have demonstrated the effects of remote CR on exercise tolerance. However, the preventive effects of remote CR on cardiac events and mortality remain controversial. Thus, safe and effective remote CR requires exercise risk stratification for each patient, telenursing by skilled staff, and multidisciplinary interventions. Therefore, quality assurance of telenursing and multi-disciplinary interventions will be essential for remote CR. Remote CR may become an important part of cardiac management in the future. However, issues such as costeffectiveness and insurance coverage still persist.