The purpose of this study is to evaluate the effects of Chu-ma therapy and to suggest that the therapy is an effective nursing intervention tool to reduce blood pressure. The research design employed was the non-synchronized research method with non- equivalent control group. A total of 30 people with essential hypertension, who were from forty to sixty five years old, participated in the study. The Chu-ma therapy was administered by every day for ten or fifteen minutes for eight weeks from 19, April to 13, June in 1999. In order to evaluate the effects of Chu-ma therapy, blood pressure of the two groups were measured once a week, and physiological parameters (epinephrine, norepinephrine, total cholesterol, HDL-cholesterol, triglycerides) were measured before and after the treatment. Collected data was analyzed by SAS package. The results of this study can be summarized as follows: 1) There were significant decrease in systolic blood pressure and diastolic blood pressure in the experimental group. 2) There were no significant changes in epinephrine, norepinephrine of the two groups. 3) There were significant decrease in total cholesterol and triglycerides, and HDL- cholesterol increased significantly in the experimental group. 4) The effect of Chu-ma therapy on the measured time on the blood pressure in experimental group was as follows: Both of systolic and diastolic blood pressures were significantly decreased after 5weeks. The result proved that Chu-ma therapy is an effective nursing intervention tool for clients with essential hypertenion. However further research is still necessary to compare the effect with the different periods and number of times for Chu-ma therapy.
Blood Pressure* ; Cholesterol ; Epinephrine ; Hypertension* ; Norepinephrine ; Nursing ; Research Design ; Triglycerides

1. It was attempted to clarify the mechanism of the pressor response to raised intracranial pressure in urethane-anesthetized rabbits. 2. Intraventricular clonidine markedly inhibited the pressor response to raised intracranial pressure. 3. Intraventricular regitine antagonized the above mentioned inhibitory effect of clonidine on the pressor response. 4. In reserpine-treated rabbits the pressor response to raised intracranial pressure was not observed, whereas after the intraventricular administration of norepinephrine the pressor response was observed. 5. Intraventricular clonidine inhibited the pressor response that could be observed in the reserpine-treated rabbits after the intraventricular norepinephrine. 6. It is inferred that raised intracranial pressure stimulated some part of the brain to cause the increase of norepinephrine release, resulting in the increase of the sympathetic outflow and the elevation of blood pressure.
Blood Pressure ; Brain ; Clonidine* ; Intracranial Pressure* ; Norepinephrine ; Phentolamine* ; Rabbits*

The aim of the present study was to examine the effects of platycodin D and D3, which are active components derived from the roots of Platycodon grandiflorum A. DC., on the contractile force of the i3olated rat aorta and blood pressure of the anesthetized rat, and also to elucidate its mechanism of action. Both phenylephrine (an adrenergic alpha1-receptor agonist) and high potassium (a membrane- depolarizing agent) caused great contractile responses in the isolated aortic strips. Platycodin D at high concentration (24microgram/ml) inhibited contractile responses induced by phenylephrine (10 (-5) M) and high potassium (5.6x10 (-2) M), while low concentrations of platycodin D (4~8microgram/ml) did not affect those responses. However, platycodin D3 (8~32microgram/ml) did not alter the contractile responses evoked by phenylephrine and high K+. Interestingly, the infusion of platycodin D3 (1.0 mg/kg/30 min) significantly reduced the pressor responses induced by intravenous norepinephrine. However, platycodin D3 (1.0 mg/kg/30 min) did not affect them. Taken together, these results show that intravenously administered platycodin D depresses norepinephrine-induced pressor responses in the anesthetized rat, at least partly through the blockade of adrenergic alpha1-receptors. Platycodin D also caused vascular relaxation in the isolated aortic strips of the rat via the blockade of adrenergic alpha1-receptors, in addition to an unknown direct mechanism. However, platycodin D3 did not affect both norepinephrine-induced pressor responses and the isolated rat aortic contractile responses evoked by phenylephrine and high potassium. Based on these results, there seems to be much difference in the mode of action between platycodin D and platycodin D3.
Animals ; Aorta ; Blood Pressure ; Norepinephrine ; Phenylephrine ; Platycodon ; Potassium ; Rats* ; Relaxation

Hyperglycemia during either global or regional ischemia is widely known to be detrimental, and ischemia induced release of diverse neurotransmitters and the ensuing activation of specific postsynaptic receptors have been suggested to play a important role in the development of ischemic selective vulunerability. This study was undertaken to investigate the influence of blood glucose change on tissue concentration of some catecholamines ; dopamine, norepinephrine, serotonin, of the transient ischemic rat's brain, estimated by high performance liquid chromatography(HPLC) assay system, following transient bilateral forebrain ischemia in the rat's model subjected to 20 minutes of normothermic ischemia by two vesseles occulusion plus profound cortex, hippocampus and striatum respectively by HLPC. The concentrations of catecholamines were significantly decreased in all sampled areas in experimental groups compared with the control group(p<0.05), respectively(average decrease rate : norepinephrine 71%, dopamine 89%, serotonin 80% in frontal cortex ; norepinephrine 71%, dopamine 93%, serotonin 81% in hippocampus ; norepinephrine 33%, dopamine 35%, serotonin 78% in striatum). Dopamine was relatively decreased in concentration in frontal cortex and hippocampus, and serotonin was relatively decreased in striatum. But no statistic significancy(p>0.05) of catecholamines level between each experimental group(hyper-, hypo- and normoglycemic group) according to the change of blood sugar. The results suggested that blood glucose level did not influence the tissue concentration of dopamine, norepinephrine and serotonin in frontl cortex, hippocampus and striatum of transient ischemic rat's brain.
Blood Glucose* ; Brain* ; Catecholamines ; Dopamine* ; Frontal Lobe* ; Hippocampus* ; Hyperglycemia ; Ischemia ; Neurotransmitter Agents ; Norepinephrine* ; Prosencephalon ; Serotonin*

Ketamine produces an increase in the heart rate and blood pressure, but the precise mechanism is controversial. In order to obtain inslight into the mechanism by observing the influence of nitroglycerin (NTG) on the ketamine effect, ketamine was administered intravenously following sublingual administration of nitroglycerin in conscious patients. The results were as follows: 1) In the ketamine(2mg/kg) group(n=15), the heart rate and blood pressure increased significantly by as much as 25%. 2) In the nitroglycerin(1.2mg) group(n=12), the heart rate increased, but blood pressure decreased from 5 minutes after administration. 3) In the group which received ketamine(2mg/kg) 5min. after NTG(1.2mg)(N=15), the heart rate did not change, but the blood pressure increased significantly without attenuation by nitroglycerin. From the above results, it is suggested that in the ketamine effect control mechanism may also be participated in addition ot the peripheral mechanism involving norepinephrine release.
Administration, Sublingual ; Blood Pressure* ; Heart Rate* ; Heart* ; Humans ; Ketamine* ; Nitroglycerin* ; Norepinephrine

The reaction to stress, while vital to the conscious animal, may be detrimental to the surgical patient. To assess the stress-associated action of halothane and its doses, we studied the responses in plasma norepinephrine, epinephrine, blood pressure and heart rate to changes of halothane concentration from 0 MAC to 1.5 MAC in 8 healthy adults. Systolic blood pressure, diastolic blood pressure and mean blood pressure were decreased as the concentration of the halothane increased from 0 MAC 0.5 MAC, 1.0 MAC and 1.5 MAC, respectively. But norepinephrine and epinephrine show no statistic ally significant response to changes in the concentration of halothane.
Adult ; Anesthesia ; Animals ; Blood Pressure ; Epinephrine* ; Halothane* ; Heart Rate ; Humans ; Norepinephrine* ; Plasma*

The purpose of this study is to evaluate the effects of QiGong gymnastics exercise program in the physiopsychological parameter inessential hypertension. The design of the research was a one group pretest-posttest design. A total of 20 patients with hypertension who were from forty to sixty-five years old participated in the study. The Qi Gong gymnastics program was carried out twice a week for thirty minutes or forty minutes for six weeks from 22, Sep. to 31, Oct. in 1997. In order to evaluate the effect of the QiGong gymnastics program physiological parameter(blood pressure, pulse rate, FVC, FEV1, Epinephrine, Norepinephrine, Cortisol) and psychological parameter(self-efficacy, Life satisfaction) were measured before and after the exercise program. Collected data was analyzed by the paired t-test with SAS package. The result are as follows: 1) There were significant decrease in systolic blood pressure and diastolic pressure, but there was no significant change in pulse rate. 2) There were no significant difference in FVC and FEV1. 3) There were significant decrease in epinephrine, norepinephrine and cortisol. 4) There were significant improved in general self-efficacy and life satisfaction. 5) The effect of QiGong gymnastics program by measurement time on blood pressure and pulse rate were as follows: In a systolic blood pressure was gradually significant decreased from 1 week to 6 weeks and diastolic blood pressure was significantly decreased after 4 weeks. But there was no significant in pulse rate. This results suggest that QiGong gymnastics are an appropriate nursing intervention for clients with hypertension. For further research is necessary to reevaluate the effect with a letter experimental design and longer period than 8 weeks for the QiGong gymnastics program.
Blood Pressure ; Epinephrine ; Gymnastics* ; Heart Rate ; Humans ; Hydrocortisone ; Hypertension* ; Norepinephrine ; Nursing ; Qi* ; Qigong* ; Research Design

BACKGROUND: Angiotensin-converting enzyme inhibitors (ACE-I) have been widely used for cardiac patients. This study investigated the effect of omitting ACE-I medication on hemodynamics during induction of anaesthesia and operation in patients chronically treated with ACE-I undergoing off pump coronary artery bypass graft surgery (OPCAB). METHODS: Sixty patients scheduled for OPCAB were included in this study. Patients not treated with ACE-I were included in control group (Group 1, n = 20). And then, patients treated with ACE-I more than 4 weeks were randomly divided into two groups: continuing group including patients who continued ACE-I medication until the morning of surgery (Group 2, n = 20) and discontinuing group including patients who discontinued ACE-I one day before the surgery (Group 3, n = 20). Norepinephrine (8microgram/ml) was infused when systolic blood pressure decreased below 90 mmHg during induction and operation. Amount of norepinephrine infused and hemodynamic data were recorded. RESULTS: Significantly larger amount of norepinephrine was infused in Group 2 than in other two groups during obtuse marginal artery anastomosis. Total amount of norepinephrine infused during the all coronary anatsomosis was significantly larger in Group 2 than those values in other two groups. CONCLUSIONS: Continuing ACE-I treatment until the morning of surgery significantly increased the use of norepinephrine during the anastomosis. In contrast, there was no significant difference in the use of norepinephrine between Group 1 and Group 3. Discontinuing ACE-I before the surgery may helpful to maintain hemodynamics stable during coronary anastomosis in OPCAB.
Angiotensin-Converting Enzyme Inhibitors ; Arteries ; Blood Pressure ; Coronary Artery Bypass, Off-Pump* ; Hemodynamics* ; Humans ; Norepinephrine ; Transplants

To evaluate the relationship between depth of anesthesia and plasma catecholamine concentration, the authors measured blood pressure(systolic, diastolic, mean), heart rate and plasma concentration of epinephrine and norepinephrine at varying condition of no anesthesia, under anesthesia and after stimulation. The subjects were 30 ASA class 1 surgical patients, aged from 20 to 40 years. Patients were given thiopental(4 mg/kg) and vecuronium(0.1 mg/kg) for induction and intubation. After 5 minutes controlled respiration with 100% oxygen, baseline measurements were taken. Measurements after 20 minutes maintenance with 1.7 vol % enflurane by end tidal concentration and measurement after skin incision were taken. Systolic pressure were 143.5+/-16.7, 107.6+/-15.0, 130.4+/-13,1lmmHg), and heart rate 115. 5+/-15.2, 85.1 +/-l5.3, 104.5+/-12.7(beat/min), plasma epinephrine concentration 93.6+/-48.4, 78.2+/-33.2, 77.0+/-23.5(ng/L), plasma norepinephrine concentration 451.6+/-154.7, 410+/-139.0, 376.7+/-104.3(ng/L), respectively. Systolic, diastolic and mean blood pressure showed significant change(p<0.05) but heart rate and plasma concentration of epinephrine and norepinephrine showed no significant changes.
Anesthesia ; Blood Pressure ; Enflurane ; Epinephrine ; Heart Rate* ; Heart* ; Humans ; Intubation ; Norepinephrine ; Oxygen ; Plasma* ; Respiration ; Skin

Serum epinephrine and norepinephrine concentrations were measured in 7 patients during fentanyl-oxygen anesthesia, who were undergoing elective open heart surgery(single valvular replacement operations) in Seoul National University Hospital. Sampling times and corresponding total fentanyl doses were as follows; 1) after arterial cannulation 2) 5 minutes after intubation(50 ug/kg of B. Wt) 3) 5 minutes after sternotomy(65 ug/ka) 4) after aortic dissection(75 ug/kg) 5) 15 minutes after initiating bypass 6) 60 minutes after initiating bypass [20 ug/kg of fentanyl was added to the priming solution before initiation of Cardio-pulmonary bypass(CP bypass)]. High Performance Liquid Chromatography(HPLC) was used to analyze hormones. Epinephrine concentrations(pg/ml) corresponding to the sampling times were as follows (mean+/-SE); 1) 213+/-59 2) 199+/-62 3) 246+/-83 4) 173+/-35 5) 270+/-70 6) 269+/-70 Norepinephrine concentrations(pg/ml) were as follows(mean+/-SE); 1) 609+/-107 2) 500+/-73 3) 645+/-152 4) 470+/-82 5) 494+/-65 6) 955+/-311 There were no significant hormonal changes except the 6th norepinephrine value. There were no significant hemodynamic changes except blood pressure decrease at the beginning of CP bypass. It is concluded that high dose fentanyl-oxygen anesthesia was limitedly effective to block the stress of open heart surgery, general anesthesia and CP bypass.
Anesthesia* ; Anesthesia, General ; Blood Pressure ; Catheterization ; Epinephrine ; Fentanyl* ; Heart* ; Hemodynamics ; Humans ; Norepinephrine ; Oxygen* ; Seoul ; Thoracic Surgery*