1.Atypical Clival Chordoma in an Adolescent without Imaging Evidence of Bone Involvement
Hilwati Hashim ; Azmin Kass Rosman ; Aida Abdul Aziz ; Abdul Kadir Roqiah ; Nor Salmah Bakar
Malaysian Journal of Medical Sciences 2014;21(5):78-82
Clival chordoma is a rare primary bone tumour that arises from the remnant of the notochord and typically occurs in older adults. Upon imaging, the tumour can be seen arising from the clivus and causes clival destruction. This usually provides insight for a diagnosis. Here we present a case of a non-enhancing, pre-pontine mass that was hypointense on T1W and hyperintense on T2W in an adolescent. No clival bone erosion was observed. Based on the age group, imaging findings, and lack of clival erosion, a provisional diagnosis of epidermoid cyst was made and the tumour was resected. This patient was eventually diagnosed with a clival chordoma based on histopathological examination.
2.Pulmonary actinomycosis masquerading as aspergilloma
Rosdina Zamrud ; Nurul Yaqeen Mohd Esa ; Mohammad Hanafiah ; Nor Salmah Bakar
The Medical Journal of Malaysia 2017;72(2):147-149
We report a case of a 34-year-old man who was initially
treated as community acquired pneumonia following a
three-month-history of productive cough, loss of weight and
loss of appetite. However, three months after discharged
from the hospital, he presented again with worsening
respiratory symptoms and radiological evidence of a lung
cavitation with intracavitary lesion resembling an
aspergilloma associated with surrounding consolidation.
Unfortunately, he remained symptomatic despite on
antifungal therapy. The repeat computed-tomography
demonstrated persistent cavitating lesion with development
of necrotising pneumonia. He underwent lobectomy and the
histopathological analysis of the resected specimen
however revealed the diagnosis of actinomycosis.
KEY WORDS:
Actinomycosis, Aspergillosis
Actinomycosis
4.Glutathione (GSH) improves sperm quality and testicular morphology in streptozotocin-induced diabetic mice.
Fathiah ABDULLAH ; Mohamed Noor KHAN NOR-ASHIKIN ; Renu AGARWAL ; Yuhaniza Shafinie KAMSANI ; Mastura ABD MALEK ; Nor Salmah BAKAR ; Aqila-Akmal MOHAMMAD KAMAL ; Mimi-Sophia SARBANDI ; Nor-Shahida ABDUL RAHMAN ; Nurul Huda MUSA
Asian Journal of Andrology 2021;23(3):281-287
Diabetes mellitus (DM) is known to cause reproductive impairment. In men, it has been linked to altered sperm quality and testicular damage. Oxidative stress (OS) plays a pivotal role in the development of DM complications. Glutathione (GSH) is a part of a nonenzymatic antioxidant defense system that protects lipid, protein, and nucleic acids from oxidative damage. However, the protective effects of exogenous GSH on the male reproductive system have not been comprehensively examined. This study determined the impact of GSH supplementation in ameliorating the adverse effect of type 1 DM on sperm quality and the seminiferous tubules of diabetic C57BL/6NTac mice. GSH at the doses of 15 mg kg