Objective To investigate the drug resistance of Acinetobacter baumannii and antibiotics use density of all kinds of antibacterial drugs before and after special antibacterial drugs remediation , provide evidence for the follow-up intervention strategies . Methods The experimental results of detected 562 cases Acinetobacter baumannii and sensitivity test were analyzed in our hospital in 2011-2012 , combined with using of every type of antibacterial drugs on different time period .Results The number of bacteria detec-ted half year had no significant difference during 2011-2012 .The antibiotics use density of beta-lactam、fluroquinoloncs and aminogly-cosides declined 22.22(31.92%)、4.19(46.29%)、5.24(68.83%) respectively by special antibacterial drugs remediation .Beta-lactam resistance rates declined significantly to 25%~30%, fluroquinoloncs and aminoglycosides resistance rates also declined , from 50%of the critical point to 20%~30%in the second half of 2012 .Conclusion Standardization of antibiotics use density of various antibacterial drugs could help reduce bacterial resistance .