The study was conducted to assess the effectiveness of the artesunate in 7-day treatment course on uncomplicated P.falciparum malaria from August to December 2003, in the Phuoc Hoa and Phuoc Thang communes, Bac Ai district, Ninh Thuan province. The clinical trials were implemented in conformity with the WHO Guidelines 2001. Artesunate with total dose of 16 mg/kg body weight was used for 7days in 159 patients with uncomplicated P. falciparum malaria. The oral treatment of patients was supervised strictly; the clinical assessment and parasite density were followed up during 28 days after treatment. The number of patients completing 28-day follow-up was 131 cases. The trial results showed that the success rate of treatment was 122/131 (accounting for 93.1%) cases, the mean fever clearance time (mean +/- SD) was 1.2:+/- 0.4 days, the mean parasite clearance time was 1.8+/- 0.7 days and the rate of late treatment failure was 9/131 cases (6.9%)
Malaria ; Malaria, ; Falciparum ; Artemisinins

There were 1.000 people (accounting for 43% of population) received blood slide examination in Thanh commune, Huong Hoa district, Quang Tri province, from 10/10/2002 to 15/12/2002. Of which 170 people got malaria parasites with 84 cases of single P.falciparum infection, 46 cases of single P.vavax infection and 40 cases of mix infection P.vivax + P.falciparum. The rate of malaria infection in children under 14 years old was high (67.6%). The cure rate of 51 patients with uncomplicated P.falciparum malaria received SR2 ( a single dose of 25mg sulfadoxine + 1.25 mg pyrimethamine/kg) by day 28 was 87.7%. In this survey, 532 people were received Paracheck-Pf and bloot slides examination by microscope. The results showed that 101 cases were found to be positive(+) with Paracheck-Pf. Of which 87 cases (86.1%) with P.falciparum were found by blood slide examination and 14 cases (13.9%) were negative
Malaria ; Pharmaceutical Preparations ; Disease ; Therapeutics ; drugs

In 1998-2002 year period, those studies were developed in LaoCai, LaiChau, QuangTri, Daklak, GiaLai and KonTum. Malarial patients with P. falciparum without complication were administered orally by a total dose of Chloroquine 25mg/kg in 3 day treating course or an unique dose of sulfadoxin-pyrimethamin.The use of medicines was observed and the parasitic density was monitored within 28 days after the treatment. Results showed the failure rate at almost studied locations
Malaria ; Therapeutics ; Pharmaceutical Preparations ; Malaria, Falciparum ; Drug Resistance ; Chloroquine ; Pyrimethamine

The clinical studies were carried-out in the commune Health Center of Quang Tri and Ninh Thuan provinces from June to December, 2003. Recrudescence and re-infection analysises by PCR method were performed at NIMPE`s laboratory. The efficacy of Erapas was evaluated for uncomplicated P.falciparum malaria with 5-day regimens (4mg/kg on the first day, followed by 2mg/kg once a day for 4 days). 109 patients were gathered in a group of Erapas treatment. Of which, 102 patients were followed-up to Day 28. Blood sample PCR analysises of 2 patients having parasite re-appearance at day 21 showed that both 2 cases were P.falciparum re-infection. The median (range) fever clearance time was 1.3 (1-2) day(s). The median (range) parasite clearance time was 2.5 (1-3) day(s). The research results showed that the cure rate by the 28¬th day was 100%. Erapas has high effectiveness for treament of uncomplicates faciparum malaria with high tolerance
malaria ; Malaria, Falciparum ; Therapeutics ; Artemisinins