1.Generic drug- review of ibuprofen
Nomingerel B ; Enkhzaya B ; Ulambayr L ; Baynmunkh A
Mongolian Pharmacy and Pharmacology 2021;19(2):120-129
In recent years, due to increased drug use global generic drugs in 2019, the industry generated 79 billion U.S. dollars in generic prescription drug revenue worldwide. Until 2026, the global prescribed generics market is expected to exceed 100 billion U.S. dollars.
The study of generic drugs will be based on the list of comparative products approved by the World Health Organization. The World Health Organization has approved the International List of Essential medicines of international comparator products based on the ANNEX-7 and ANNEX-8. That list includes a total of 572 international comparator products.
Generic drugs has an important role in the market of any country, and generic drugs are required to be similar to comparator products in terms of therapeutic activity, quality, and safety. In multi sources generic drug is equivalent to the treatment of the comparable product, allowing the product to be used as a substitute for analysis.
Some results of recent studies of Ibuprofen is mentioned above here.
In 2010 in Madrid, Spain, the study Investigation on the possibility of biowaivers for Ibuprofen was conducted by Covadonga Lvarez, Ignacio Nunenz, Juan J. Torrado and John Gordon. The aim of the study was to investigate the ability of in vitro dissolution to ensure bioequivalence of ibuprofen products. Ibuprofen is a Biopharmaceutics Classification System (BCS) class II drug with low solubility at pH 1.2 and 4.5 and high solubility at pH 6.8. In vivo studies were performed following the updated Declaration of Helsinki, with the approval of the Ethical Committee for Clinical Re- search of the Hospital and the Spanish Agency for Medicines and Health Care Products.
In-vitro evaluation of the pharmaceutical quality of some ibuprofen tablets dispensed in Nigeria, University of Benin, Department of Pharmaceutics and Pharmaceutical Technology, analyzed Florence E. Eichie*, Ikhuoria M. Arhewoh and Oliver C. Ezeobi. The Ibuprofen tablets were assessed according to British Pharmacopoeia (BP), and unofficial standards as recommended by the manufacturers. Of the 19 brands of tablets assessed, 12 brands passed the uniformity of content test while 15 brands passed the disintegration test and only four brands passed the dissolution test. Ibuprofen tablets dispensed in Nigeria varied considerably in their pharmaceutical quality.
In 2015 in Nigeria, Benin City, University of Benin, Department of Pharmaceutics and Pharmaceutical Technology, Studies of comparative UV−HPLC analysis of ten brands of ibuprofen tablets. Those studies investigated the pharmaceutical equivalence of ten brands of ibuprofen tablets (400 mg) purchased from pharmacies in Benin City, Nigeria. According to the results of the study, the weight of the total brand of drugs varies significantly, fluctuates between 6.14-15.93kp due to the action of pressure, and the melting point does not meet the requirements of brands B and G. Drug decomposition brands C, F, H, I meet the requirements, but the solubility indicators D, E, G, I, J inadequate requirements. Brands C and D inadequate requirements for determining the content of ibuprofen in ultraviolet light. However, all brands of drugs approved requirements for HPLC.
In 2020 in Mekelle, Ethiopia, Comparative In Vitro Quality Evaluation of Different Brands of Ibuprofen Tablets Marketed. Studies included seven brands of 400 mg lm coated ibuprofen tablets were randomly purchased from different pharmacies and drug stores in Mekelle. Weight uniformity, hardness, friability, disintegration, dissolution and assay of drug content were performed based on specications stipulated in the British Pharmacopeia (BP) and the United State Pharmacopeia (USP). All the evaluated products of ibuprofen tablets marketed in Mekelle were within the acceptable compendial limits based on the in vitro results of the study except product IBU-E which failed in the disintegration test.
The aim of the study to determine the in vitro quality of some domestic and imported ibuprofen drugs.
2.Mongolian Health Human Resource management plan
Nyamjargal U ; Nomingerel S ; Amarsailhan B
Innovation 2018;12(4):58-
Mongolian health human resources’ main goal is to provide effective and indiscriminate service that is evenly distributed among each individual in country. In order to achieve its goal, the general health policy should focus on its human resources management.
This research work was done with document research method and got all the necessary information from databases of Public Health Development Center, Mongolian National statistical agency, Ministry of Health and Ministry of Education Culture and Science.
There are 32.4 chief doctors, 37.2 nurses and 24 other health employees assigned to work for 10000 people from the study of 2016. Comparing this study with the previous year’s study, the number of the doctors has gone up by 0.8, but the number of the nurses has gone down by 0.3. Due to the WHO’s statistic, the number of the patients per doctor is considered to be low.
The exact population of Mongolia is 3.119.935 in 2016. To compare the population spread through the country, Ulaanbaatar, capital city, has the highest density of population. The number of the hospitals and doctors were enough. Actually it was lower than world standard (500 patients per a doctor). Even the number of the doctors are enough, in remote area, it is not enough. In the whole country there are 309 patients per doctor, 237 patients per doctor in Ulaanbaatar and 433 patients per doctor in isolated areas. In conclusion, the human resource distribution is not even in the public health care.
3.УЛААНБААТАР ХОТЫН ХҮН АМЫН ДУНДАХ АМИА ЕГҮҮТГЭХ ТОХИОЛДЛЫН СУДАЛГАА
Ariunjargal B ; Uranbileg D ; Ishkhand B ; Nomingerel E ; Tserenbat M ; Unurmaa B
Innovation 2017;11(2):13-15
BACKGROUND. In the worldwide every 40 seconds one person takes their life, annually 1
million people die on Earth by the means of suicide. Regardless of gender it is one of the
main 3 causes of death in the population aged between 15-29. There have a tendency
to increase of suicide rates with each passing year in the Mongolia. Therefore, our study
goal is to determine the utilized methods and to identify some of the factors influencing
the escalation of this phenomenon. The data and materials were gathered by quantitative
research method from the post-mortem examination reports provided from the
central archive of National Institute of Forensic Science according to the descriptive
research design.
The fact that the bulk of the increasing suicide cases might be attributed to the unemployed
and working-age men without any chronic illnesses suggests correlation with
gender and socio-economic status.
4.Evaluation on satisfaction of customers and medical professionals at pharmacies of Ulaanbaatar
Uyangaa B ; Nomingerel B ; Altantsetseg A ; Ulambayar L ; Bazarragchaa S
Mongolian Pharmacy and Pharmacology 2023;23(2):33-40
Introduction:
Pharmacist and customer satisfaction is unique to other industries because it has a significant impact
on patient outcomes and the quality of primary health care. In the framework of health sector reforms,
improving the ethics and attitudes of medical professionals, the quality of care, internal environment
and safety has become a priority issue for the development of the organization.
According to statistical data, in 2020, there are 2343 second-class pharmacies in Mongolia, 1254 in
Ulaanbaatar, and 1249 pharmacies in Ulaanbaatar in 2021. As of 2020, there are 2639 pharmacists
and 2009 drug directors working in the country, and in 2021, there are 2913 pharmacists and 2010
drug directors. Compared to the previous year, the number of pharmacists has increased by 0.8%,
and the number of drug directors has increased by 13% has indicators. According to the above statistics, it is appropriate to study the satisfaction of specialists and clients in line with the increasing
number of pharmacies and specialists.
As of the 1st quarter of 2023, pharmaceutical experts who play an important role in the quality and
availability of pharmacy services and social economic development in the world (Pakistan, America,
Canada. Great Britain, Spain, South Africa, etc.) Because it is important to study the satisfaction of
pharmacists and the satisfaction of pharmacy users, we are conducting regular satisfaction surveys.
Purpose and objectives:
The purpose of the research is to evaluate the satisfaction of customers and pharmacists in the pharmacy of Ulaanbaatar. For this purpose, the following objectives were proposed. It includes:
1. Survey of pharmaceutical experts and pharmacy users determine the sample size
2. To evaluate the satisfaction of pharmacy users through a questionnaire
3. To evaluate the satisfaction of pharmacists by questionnaire
4. Compare the level of satisfaction by age group and perform statistical processing
Materials and methods:
A survey of pharmacy customers and pharmacist satisfaction was conducted using a Cross-sectional
studies model. The Survey system calculator was used to calculate the sample size based on the
representativeness of the sample to be studied. The survey was conducted between the 4th quarter
of 2022 and the 2nd quarter of 2023. and the satisfaction of customers and pharmacists was obtained by random sampling by the UB City Hospitals and Health Deparments, and data was collected using 2 types of questionnaires to be evaluated on a 5-point Likert scale using the SERVQUAL model. The results were processed using Microsoft Excel and SPSS 23.0 software. The reliability of the survey questionnaire was calculated using the Cronbach alpha coefficient.
Results:
A total of 758 people participated in our study, and satisfaction was determined by including n=369 pharmacists and n=389 customers, respectively. A breakdown of the results:
369 pharmacists participated in the survey, and according to the total number of questions, 48.0%
n=177 are satisfied, 37.7% n=139 are very satisfied. Considering the satisfied age group of pharmaceutical specialists, n=101 specialists in the age group of 26-35 years are the most satisfied.
52.85% n=195 satisfied. 25.20% n=93 Very satisfied, 20.87% n=77 Moderately satisfied, 0.54% n=2
Not at all satisfied, 0.54% n=2 He replied that he did not know. According to the results of the survey,
pharmaceutical professionals are highly satisfied.
On the other hand, 389 customers participated in the satisfaction survey of pharmacy users, and
according to the total results of the group questions, 67.4% n=262 customers were moderately satisfied with the organization's care and service culture and intimate environment outside the organization is satisfied. Looking at the satisfaction of pharmacy customers by age group, n=121 customers under 25 years of age have moderate satisfaction is satisfied.
49.61% n=193 not satisfied at all, 35.22% n=137 Moderately satisfied with the pharmacy services
from the surveyed customers, degree, 9.55% n=37 Very satisfied, 5.66% n=22 answered that they
do not know. Therefore, it shows the need to consider the quality of care.
Conclusion
369 experts were included in the survey to evaluate the satisfaction of customers and pharmacists with the pharmacy, and 2 groups of evaluations were used in the survey. The reliability of the
22 questionnaires, calculated by Cronbach's alpha coefficient, is good between 0.9 a≥0.846. The
majority of pharmaceutical professionals (n=316) surveyed are satisfied with their profession and
workplace.
However, the reliability of the questionnaire used in the research to evaluate the satisfaction of customers in the pharmacy, when calculated by Cronbach's alpha coefficient, is acceptable between 0,8 a≥0.777. The n=262 customers surveyed are moderately satisfied with pharmacy services.
Depending on the age group of the people involved in the research, the location where they work
and serve, the relationship attitude, understanding, and workload satisfaction level are different.
5.The issue of people with disability: (Pharmaceutical care services)
Anujin S ; Adilbish L ; AItantsetseg A ; UIambayar B ; Odgerel P ; Zultsetsetseg N ; Nomingerel B
Mongolian Pharmacy and Pharmacology 2023;23(2):47-52
Introduction:
16% of the world's 8 billion people, or more than 1.3 billion, are people with special needs or people with disabilities. Of these, there are unofficial studies that show that there are about 650 million people with disabilities in Asian countries. [1] One of the most common problems faced by people with special needs is that disability service organizations, especially pharmacies, do not have access to complete information on their necessary medications.
According to the 2019 data of the National Statistics Committee [4] in our country, 3.4 percent of the total population or 107.6 thousand are citizens with special needs. Article 1.1 of the Law "On the Rights of Persons with Disabilities" [5] provides for the equal rights of persons with disabilities to participate in social relations, to ensure and implement them, to provide an accessible environment, to create conditions, housing, public buildings, roads, public transport, and information., communication technology is included as being accessible to people with disabilities. However, health and pharmacy services for people with special needs are very challenging.
The main basis of this research work is to make pharmacy services easier for people with special needs, especially people with speech, hearing, visual, mental, and motor disabilities, and to identify and solve problems.
Methods:
The research was carried out in a one-moment model. Based on the General Department of Development of People with Disabilities, data was collected by questionnaire using the minimum sample size calculation, which was calculated as 478 people per 1000 population. Statistical analysis was carried out using SPSS-23 software.
Our survey was conducted between November to December 1, 2022 using a snapshot model. Processing of results was carried out using survey data processing.
Conclusion
1. According to the 2019 data of the National Statistics Committee, 3.4 percent or 107.6 thousand of the total population of our country are citizens with special needs. This information has not been updated for 2021-2022.
Out of a total of 478 people in the survey, 54% were male, while 42.8% of the respondents were 20-30 years old. 48.8% of citizens use pharmacies independently, 42.4% with the help of a guardian, and 8.8% of other citizens use pharmacies. The lack of understanding of drug information on prescription forms affects the physician's prescription, drug information, visual and hearing impairments, and misunderstandings.
2. People with speech, hearing, visual, mental, and motor disabilities face the biggest problem in using the pharmacy. Therefore, it is a priority to make certain innovative changes in order to make pharmacy operation* equal to citizens. These include: Prescription forms can be read using technology such as Qr and AR on the phone, delivering medication instructions and information in audio form to people with visual and mental disabilities, providing more clear and understandable information to people with speech and hearing disabilities identifying medications for people with visual impairments, and using drugs correctly. We believe that suggestions and solutions are needed, such as placing names and instructions in braille on product labeling and packaging, implementing stairs and doors for people in wheelchairs or with mobility impairments in accordance with standards in all buildings, and providing seats for stairwells between floors. In most cases, it takes 10-20 minutes for people with disabilities to visit a pharmacy. Some citizens are experiencing delays in services for up to an hour. It can be seen that spending a lot of time to visit a pharmacy is difficult for citizens.
In order to solve this problem, under the supervision of a manager and a pharmacist, a post-graduate student of "Pharmacy" of the "University of Pharmaceutical Sciences" should be created to provide advice and information to citizens and reduce the burden.