Nocardia is an aerobic gram-positive, weak acid-fast, branching, filamentous bacteria causing various clinical infections such as pulmonary nocardiosis, systemic nocardiosis, extrapulmonary nocardiosis, cutaneous nocardiosis and nocardial mycetoma. They are most commonly caused by N. asteroides complex. Humans become infected by inhaling contaminated air-borne dust particles or by traumatic implantation of the bacterium into the subcutaneous tissues. We isolated Nocardia asteroides complex from the hemo-vac of trauma patient and CSFs of two hydrocephalus patients. Nocardia asteroides complex has been isolated less commonly in Korea than in other countries. We think that it is important to extend an incubation time of culture plate when we find the gram positive, branched, beaded filaments and coccoid cells.
Bacteria ; Cerebrospinal Fluid* ; Dust ; Humans ; Hydrocephalus ; Inhalation ; Korea ; Mycetoma ; Nocardia asteroides* ; Nocardia Infections ; Nocardia* ; Subcutaneous Tissue ; Wounds and Injuries*

No abstract available.
Nocardia Infections* ; Nocardia*

No abstract available.
Nocardia Infections*

Nocardia is aerobic gram positive bacteria, which is found in the soil. Cutaneous nocardiosis is divided into the primary skin infection and secondary infection due to systemic dissemination from the internal organ. Its clinical manifestations are mycetoma, lymphocutaneous infection and superficial infection, such as abscess or granuloma. In lymphocutaneous infection, it is important to make differential diagnosis with other diseases with sporotrichoid pattern, such as sporotrichosis, leishmaniasis and mycobacterial infection. In our case, 58 year old male who had history of chemotherapy due to lung cancer visited with granulomatous nodule on the left wrist, and following lymphangitis along the forearm for 2 months. Through a skin biopsy, culture, AFB stain and 16S rRNA gene sequencing, cutaneous nocardiosis by N. brasiliensis was diagnosed.
Abscess ; Biopsy ; Coinfection ; Diagnosis, Differential ; Forearm ; Genes, rRNA ; Gram-Positive Bacteria ; Granuloma ; Humans ; Leishmaniasis ; Lung ; Lung Neoplasms ; Lymphangitis ; Male ; Mycetoma ; Nocardia ; Nocardia Infections ; Skin ; Soil ; Sporotrichosis ; Wrist

The authors report a extemely rare case of primary cerebellar nocardial abscess. Cerebral nocardiosis is arare disease and often fatal, and commonly spreaded from nocardiosis of lung or skin. Total excision of abscess and medication with sulfonamide is the treatment of choice. The patient was treated by continuous external dirainage with intermittent irrigation of abscess cavity by sulfonamide and given with sulfonamide for 10 months.
Abscess ; Humans ; Lung ; Nocardia Infections* ; Skin

Nocardia is an opportunistic pathogen that can cause disseminated disease in serious immunosuppressive patients with organ transplantation, advanced HIV infection, malignancy or long-term corticosteroid use. Cerebral nocardiosis constitutes the most severe form of Nocardial infection. Early detection and treatment of cerebral abscess of Nocardia is important because the mortality is three times higher than that of other bacterial cerebral abscesses. We report a case of N. farcinica brain abscess in a focal segmental glomerulosclerosis (FSGS) patient after steroid treatment.
Brain ; Brain Abscess ; Glomerulosclerosis, Focal Segmental ; HIV Infections ; Humans ; Nocardia ; Nocardia Infections ; Organ Transplantation ; Steroids ; Transplants

Even though nocardiosis is one of opportunistic infections, and can occur in Cushing's syndrome, it rarely occurs in patients with Cushing's disease. Herein, a case with Cushing's disease in whom nocardiosis had manifested as a pulmonary lesion, which after percutaneous needle aspiration, empyema and a breast abscess were also noted.
Abscess ; Breast ; Cushing Syndrome ; Empyema ; Humans ; Needles ; Nocardia ; Nocardia Infections* ; Opportunistic Infections

Nocardiosis is an opportunistic infection occurring in immunocompromised patients. Worldwidely, about four cases of nocardiosis of the breast have been previously reported, but none of these were in Korea. We describe a case of breast nocardiosis associated with pulmonary infection in a patient with Cushing's disease. In our patient, multiple, well-defined, conglomerated, tubular-shaped, isodense mass was revealed at mammography, and an irregular-shaped, ill-defined, heterogeneous echoic mass with movable debris at ultrasonography.
Breast* ; Humans ; Immunocompromised Host ; Korea ; Mammography ; Nocardia ; Nocardia Infections* ; Opportunistic Infections ; Ultrasonography

Nocardiosis is well-known opportunistic infection in immunocompromised patients. The timely diagnosis and treatment, however, is still a difficult problem. Recently, as newer molecular techniques, particularly 16S rRNA sequencing, are implemented, the diagnosis and management of the infection are improving. We report a case of lung abscess in a 39-year-old-man who underwent kidney transplantation. He was diagnosed of Nocardia elegans by 16S rRNA sequencing and was cured of the infection with appropriate antibiotic therapy.
Immunocompromised Host ; Kidney ; Kidney Transplantation ; Lung ; Lung Abscess ; Nocardia ; Nocardia Infections ; Opportunistic Infections

Nocardiosis is well-known opportunistic infection in immunocompromised patients. The timely diagnosis and treatment, however, is still a difficult problem. Recently, as newer molecular techniques, particularly 16S rRNA sequencing, are implemented, the diagnosis and management of the infection are improving. We report a case of lung abscess in a 39-year-old-man who underwent kidney transplantation. He was diagnosed of Nocardia elegans by 16S rRNA sequencing and was cured of the infection with appropriate antibiotic therapy.
Immunocompromised Host ; Kidney ; Kidney Transplantation ; Lung ; Lung Abscess ; Nocardia ; Nocardia Infections ; Opportunistic Infections