Human ; Male ; Adult: 25-44 Yrs Old ; Madura Foot ; Mycetoma

BACKGROUND

Mycetoma is a chronic, progressively destructive granulomatous infection caused by fungi (eumycetoma) or bacteria (actinomycetoma). It is recognized by the WHO as a neglected tropical disease. Despite its presence globally, the incidence and burden in the Philippines remain poorly documented.

To determine the prevalence, clinicodemographic profile, and outcomes of mycetoma diagnosed at the Jose R. Reyes Memorial Medical Center - Department of Dermatology from January 2014 to December 2024.

A retrospective chart review was conducted among patients diagnosed clinically and confirmed either microbiologically and/or histopathologically with mycetoma. Data collected included age, sex, occupation, risk factors, lesion characteristics, causative agent, diagnostic method, treatment, and outcomes.

Four cases of actinomycetoma were identified, all with pedal involvement. The majority were male (75%) and over 40 years old. One patient had an agricultural occupation. Most were from outside Metro Manila. Histopathologic confirmation was present in all cases. Three patients were lost to follow-up. Only the patient treated for over 12 months achieved clinical improvement.

Mycetoma remains a rare but significant disease in the Philippines. Findings support existing literature on male predominance, pedal localization, and the importance of prolonged antimicrobial treatment. Greater surveillance, early diagnosis, and follow-up strategies are essential.

Botryomycosis is a rare pyogenic disease that presents with chronic suppurative and granulomatous skin lesions, commonly caused by Staphylococcus aureus. We report a case of botryomycosis presenting similarly to mycetoma, secondary to the emerging cutaneous pathogen Staphylococcus simulans. A 46-year-old female who previously worked in a wet market presented with a 13-year history of suppurative papules on a gradually enlarging right foot, and pain on ambulation. She had no systemic symptoms or co-morbidities, and does not recall preceding trauma. Physical examination showed brawny edema of the right foot with multiple sinus tracts draining purulent discharge. The clinical diagnosis at presentation was mycetoma. Magnetic resonance imaging showed a soft tissue mass involving the right foot and ankle with osseous destruction. Biopsy revealed suppurative granulomatous dermatitis; staining with Grocott methenamine silver did not highlight fungal elements. Potassium hydroxide mount of the purulent discharge did not show grains or hyphal elements. Tissue cultures showed growth of co-trimoxazole-susceptible Staphylococcus simulans. The patient was managed as a case of botryomycosis and treated with co-trimoxazole for 12 months. There was a significant decrease in right foot circumference along with scarring and resolution of associated pain. Repeat biopsy showed no evidence of infection. This is the first reported case of botryomycosis in the Philippines as well as the first report citing Staphyloccocus simulans as a causative agent. Botryomycosis is an important differential in patients clinically presenting as mycetoma. Animal pathogens may need to be considered as etiologic agents in at-risk patients with chronic subcutaneous infections.

Humans ; Retrospective Studies ; Bronchiectasis ; Mycobacterium avium Complex ; Syndrome ; Nocardia Infections/drug therapy* ; Nocardia ; Mycobacterium avium-intracellulare Infection

Aspergillosis ; Ethics Committees, Research ; Fungi ; Humans ; Korea ; Magnetic Resonance Imaging ; Mycetoma ; Paranasal Sinuses ; Retrospective Studies ; Sinusitis

Hematopoietic Stem Cell Transplantation ; Humans ; Nocardia Infections ; Transplantation, Homologous

We report a case of eumycetoma in a Filipino patient who presented with a solitary reddish brown, moist, multinodular tumor on the dorsum of the left foot of 2 years duration. Biopsy with Periodic acid Schiff (PAS) & Gomori methenamine silver (GMS) staining, fungal culture, ultrasound and X-ray of the foot were done in our institution which confirmed the diagnosis of eumycetoma. The patient was successfully treated with itraconazole 400/day for 3 months, followed by 200mg/day for the succeeding 9 months, leading to complete resolution of the lesion leaving an atrophic hypopigmented scar. A high index of suspicion supported by diagnostic tests aided in the early detection of the disease which also resulted to complete resolution of the disease.
Mycetoma ; Mycoses ; Itraconazole

Herein, we describe the case of a 67-year-old female patient who presented with cough and haemoptysis. Chest computed tomography revealed destruction of the left lower lobe and multiple fungus balls in a bronchiectatic cavity. A left lower lobectomy was performed via thoracotomy. Histopathological examination of the lung showed a concomitant aspergilloma and multiple tumourlets in the large bronchiectatic cavity. Pulmonary intracavitary aspergilloma and concomitant tumourlets are quite rare. Our report presents this interesting case that manifested with haemoptysis.
Aged ; Bronchiectasis ; Cough ; Female ; Fungi* ; Hemoptysis ; Humans ; Lung ; Mycetoma ; Pulmonary Aspergillosis ; Thoracotomy ; Thorax

No abstract available.
Nocardia Infections* ; Nocardia*

Pulmonary nocardiosis is a rare opportunistic infection that commonly affects immunocompromised hosts, such as patients with organ transplants, acquired immunodeficiency syndrome, or prolonged immunosuppression. Recently, we encountered a case of pulmonary nocardiosis with empyema that progressed to severe sepsis. The patient was treated in the intensive care unit. Thereafter, medical thoracoscopy was performed to improve drainage of the pleural fluid. Nocardia was identified in the culture of the pleural fluid.
Acquired Immunodeficiency Syndrome ; Drainage ; Empyema* ; Humans ; Immunocompromised Host ; Immunosuppression ; Intensive Care Units ; Nocardia Infections ; Nocardia* ; Opportunistic Infections ; Sepsis* ; Thoracoscopy ; Transplants