Objective : We performed a systematic review to investigate improvements in body function and structure, activity, and health-related quality of life from exercise programs of >150 days' duration in patients with knee osteoarthritis (OA). Methods : We collected data on randomized controlled trials (RCTs) comparing the effects of exercise intervention with those of either nonintervention or psychoeducational intervention in patients with knee OA. Data were collected on pain, stiffness, muscle strength, range of motion, flexibility, maximal oxygen uptake, proprioception, time to climb a flight of stairs, disability as assessed by the Western Ontario and McMaster Universities Arthritis Index (WOMAC), walking distance (e.g., 6-min walking-distance test), walking time (e.g., time to walk arbitrary distances), walking velocity, and health-related quality of life assessed using the SF-36^® Health Survey (SF-36). The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was used to determine the quality of the evidence. Results: Forty-one RCTs were identified. Outcomes that were significantly affected by exercise programs of >150 days were knee flexion muscle strength at a functional level, time to climb a flight of stairs and walking distance at activity level, and SF-36 General Health, Physical Functioning, Role-Physical, and Bodily Pain scales. The quality of evidence for these outcomes was moderate to high. Conclusion : In patients with knee OA, improvements in body function, activity, and health-related quality of life can be maintained with exercise programs of >150 days' duration, and these findings are supported by a moderate to high level of evidence.

A 28-year-old woman with patent foramen ovale who developed tricuspid valve infective endocarditis with complications of multiple infarctions and abscesses was treated surgically. The patient was transferred to our institution because of fever and joint pain. Echocardiography revealed a large vegetation (25 mm) on the tricuspid valve and a patent foramen ovale. Computed tomography and magnetic resonance imaging showed cerebral infarctions, multiple lung abscesses, and vertebral osteomyelitis. Staphylococcus epidermidis was identified in blood cultures. After treatment with adequate antibiotics for 5 weeks, the patient underwent surgical resection of the vegetation followed by tricuspid valve repair and direct closure of the patent foramen ovale. Antibiotic therapy was continued postoperatively, and the patient was discharged 7 weeks after the operation. No further endocarditis or embolism has occurred. In cases of right-sided endocarditis with systemic embolism and abscesses, the presence of a patent foramen ovale should be considered, and appropriate timing of the operation should be determined to prevent further systemic embolization of the vegetation.

Background :There have been only a few comparative observational studies on the safety and effectiveness of drugs in Japan. Comparative observational studies would provide important information to address these issues and thus we need to establish a means to facilitate such studies. In comparative studies, it is important to prevent the distortion of results due to selection bias. Though we do not yet have a claims database for use in pharmacoepidemiological studies, recently many hospitals and pharmacies have computerized prescription data which may be used to minimize selection bias. Good standardized procedures for the identification of patients prescribed one of two or more drugs to compare in a study using computerized prescription data would serve as a basis for a variety of pharmacoepidemiological studies in Japan.
Methods :We carried out a questionnaire survey in 2753 hospitals and 909 community pharmacies to estimate the fraction of hospitals where computerized data can be used to identify all eligible patients who used a specific drug.
Results :Questionnaires were returned by 1942 (71%) of 2753 hospitals and 632 (70%) of 909 pharmacies. From among those which responded, patients were identified, the patient list was printed, and the electronic file of the patient list was generated in 75%, 64% and 36% of the 1942 hospitals and in 100%, 93% and 49% of the 632 pharmacies respectively.
Conclusion :With procedures using computerized prescription data, the cohort for observational comparative studies may be identified with a minimal selection bias in a majority of hospitals and pharmacies.

Background: No study has compared flat and elevated-rim polyethylene liners in terms of stress distribution on the bearing surface. The purpose of this study was to investigate the difference in stress distribution between flat and elevated-rim polyethylene liners. Methods: A stress analysis was performed by using the 3-dimensional finite element method. The cup was placed at an open angle of 20°, the flat liner and the liner with a 10° elevation was placed at inclination angles of 80°, 70°, and 60°. Results: Compared with the 60° flat liner, the 80° and 70° flat liners showed higher stress at the liner edge. In the elevated-rim liner, the stress was high at the liner edge along the cup edge. When the von Mises equivalent stress was applied to each element of the liner, the high stress area (volume) was the largest for the 80° flat liner, second largest for the 80° elevated-rim liner, and third largest for the 70° flat liner. The average contact pressure also followed the same order. Conclusions Elevated-rim liners affect the stress distribution by increasing the area of contact. However, since elevated-rim liners exhibit high stress at the cup edge, they are likely to result in new problems including liner failure. These findings could aid surgeons in the selection of liners and determination of revision methods such as isolated liner exchange vs. acetabular cup revision for a well-fixed metal cup with a higher inclination angle in revision total hip arthroplasty.

Background: Implants with different neck offsets for hip replacement surgery are now available from various implant manufacturers and have become a widely used option for achieving postoperative hip stability. This study aimed to compare the impact of neck offset on initial stem fixation and the mechanical effects of different stem lengths when using cementless stems. Methods: We performed a finite element analysis using Mechanical Finder ver. 12.0. CAD models of the Profemur Preserve and Profemur TL cementless stems. Each stem was appropriately sized, and the von Mises stress was calculated. We defined micromotion as the relative displacement between the stem node and the surface of bone contact. The maximum micromotion values of these finite element models were compared under standing conditions. Results: The stress per zone for both stems (Preserve and TL) was the highest in zone 5, followed by zones 3 and 4, which were almost in line with each other. The high offset (HIGH) stress was higher than the standard offset (STD) stress in each stem and zone.The micromotion of each stem was higher at each load in the following order: Preserve HIGH, Preserve STD, TL HIGH, and TL STD, with HIGH being higher than STD at each stem. Conclusions The choice of higher offset or shorter length stems induced higher micromotion at the interface to the bone in the early postoperative period. Therefore, surgeons should be more careful to get appropriate initial fixation using shorter stems with higher offset necks due to the relatively high incidence of loosening or fractures.

Background: Implants with different neck offsets for hip replacement surgery are now available from various implant manufacturers and have become a widely used option for achieving postoperative hip stability. This study aimed to compare the impact of neck offset on initial stem fixation and the mechanical effects of different stem lengths when using cementless stems. Methods: We performed a finite element analysis using Mechanical Finder ver. 12.0. CAD models of the Profemur Preserve and Profemur TL cementless stems. Each stem was appropriately sized, and the von Mises stress was calculated. We defined micromotion as the relative displacement between the stem node and the surface of bone contact. The maximum micromotion values of these finite element models were compared under standing conditions. Results: The stress per zone for both stems (Preserve and TL) was the highest in zone 5, followed by zones 3 and 4, which were almost in line with each other. The high offset (HIGH) stress was higher than the standard offset (STD) stress in each stem and zone.The micromotion of each stem was higher at each load in the following order: Preserve HIGH, Preserve STD, TL HIGH, and TL STD, with HIGH being higher than STD at each stem. Conclusions The choice of higher offset or shorter length stems induced higher micromotion at the interface to the bone in the early postoperative period. Therefore, surgeons should be more careful to get appropriate initial fixation using shorter stems with higher offset necks due to the relatively high incidence of loosening or fractures.

Background: Implants with different neck offsets for hip replacement surgery are now available from various implant manufacturers and have become a widely used option for achieving postoperative hip stability. This study aimed to compare the impact of neck offset on initial stem fixation and the mechanical effects of different stem lengths when using cementless stems. Methods: We performed a finite element analysis using Mechanical Finder ver. 12.0. CAD models of the Profemur Preserve and Profemur TL cementless stems. Each stem was appropriately sized, and the von Mises stress was calculated. We defined micromotion as the relative displacement between the stem node and the surface of bone contact. The maximum micromotion values of these finite element models were compared under standing conditions. Results: The stress per zone for both stems (Preserve and TL) was the highest in zone 5, followed by zones 3 and 4, which were almost in line with each other. The high offset (HIGH) stress was higher than the standard offset (STD) stress in each stem and zone.The micromotion of each stem was higher at each load in the following order: Preserve HIGH, Preserve STD, TL HIGH, and TL STD, with HIGH being higher than STD at each stem. Conclusions The choice of higher offset or shorter length stems induced higher micromotion at the interface to the bone in the early postoperative period. Therefore, surgeons should be more careful to get appropriate initial fixation using shorter stems with higher offset necks due to the relatively high incidence of loosening or fractures.

Background: Implants with different neck offsets for hip replacement surgery are now available from various implant manufacturers and have become a widely used option for achieving postoperative hip stability. This study aimed to compare the impact of neck offset on initial stem fixation and the mechanical effects of different stem lengths when using cementless stems. Methods: We performed a finite element analysis using Mechanical Finder ver. 12.0. CAD models of the Profemur Preserve and Profemur TL cementless stems. Each stem was appropriately sized, and the von Mises stress was calculated. We defined micromotion as the relative displacement between the stem node and the surface of bone contact. The maximum micromotion values of these finite element models were compared under standing conditions. Results: The stress per zone for both stems (Preserve and TL) was the highest in zone 5, followed by zones 3 and 4, which were almost in line with each other. The high offset (HIGH) stress was higher than the standard offset (STD) stress in each stem and zone.The micromotion of each stem was higher at each load in the following order: Preserve HIGH, Preserve STD, TL HIGH, and TL STD, with HIGH being higher than STD at each stem. Conclusions The choice of higher offset or shorter length stems induced higher micromotion at the interface to the bone in the early postoperative period. Therefore, surgeons should be more careful to get appropriate initial fixation using shorter stems with higher offset necks due to the relatively high incidence of loosening or fractures.

BACKGROUND AND PURPOSE: Plasma D-dimer levels are elevated during the acute phase of cerebral infarction (CI). We investigated whether the D-dimer level on admission and other clinical characteristics could be used to predict the poor outcome of patients with acute CI. METHODS: The clinical characteristics and plasma D-dimer levels measured within 3 days of onset were compared according to outcome among patients with acute CI. RESULTS: In total, 359 consecutive patients (mean age, 71.8 years) were examined, of which 174 had a poor outcome [score on the modified Rankin scale (mRS) > or =3] at 30 days after hospitalization. The mean mRS score was higher and a poor outcome was observed more frequently among women than among men (p<0.001 for each). The proportions of women, cardioembolism, atrial fibrillation, advanced age (> or =75 years), prior history of CI or transient ischemic attack, and elevated D-dimer level (> or =1.0 microg/mL) were significantly higher among patients with a poor outcome than among those with a good outcome. A multivariate analysis showed that elevated D-dimer level [> or =1.0 microg/mL; odds ratio (OR), 2.45; 95% confidence interval (95% CI), 1.52-3.89; p<0.01], advanced age (OR, 1.93; 95% CI, 1.21-3.07; p<0.01), and female gender (OR, 1.75; 95% CI, 1.08-2.83; p=0.02) were independent predictors of a poor outcome. CONCLUSIONS: Certain clinical characteristics (gender and advanced age) and an elevated D-dimer level upon admission can be used to predict the outcome of patients with acute CI at 30 days after hospitalization.
Atrial Fibrillation ; Cerebral Infarction ; Female ; Fibrin Fibrinogen Degradation Products ; Hospitalization ; Humans ; Ischemic Attack, Transient ; Male ; Multivariate Analysis ; Odds Ratio ; Plasma ; Stroke