1.The antisaccade in children with autistic spectrum disorders
International Journal of Pediatrics 2010;37(5):521-523
Recent studies demonstrate that autistic spectrum disprders children have deficits in executive functiony, particularly the function referred response inhibition. The antisaccade task provides a new tool for direct evaluation of inhibitory function and a new way to explore the character of response inhibition in children with cognitive impairment. Researchers have used the technologies of eye movement to reveal the ability of oculomotor inhibition in children with autistic spectrum disprders, which is poorer than that of normal children.
2.Review of Foreign Medical Education Management
Chinese Journal of Medical Education Research 2006;0(10):-
The state of scale management,structure of hierarchy,professional institutions,educational system and degree,situation of academy and cost of medical education in developed countries was summarized in this article respectively to provide reference for our medical education reform.
3.Soft regulation of inflammatory immune responses
Chinese Pharmacological Bulletin 2016;32(3):297-303
Inflammation reaction and immune response are in-separable in the levels of system, tissue, cell and molecule. In-flammatory immune responses ( IIR) is proposed in this paper, which is defined a moderate or abnormal system responses of in-flammatory immune related cells in responding to the internal and external environment changes of body. It is described briefly that the research progresses of inflammatory immune cells ( e. g. , macrophages, dendritic cells, T cells and B cells, etc. ) and non-inflammatory immune cells ( e. g. , glial cells, endothe-lial cells, epithelial cells, fibroblasts, synovial cells and liver cells, etc. ) , and cytokines/receptor signal transduction in-volved in IIR. Moreover, the existing problems about regulating IIR drugs clinically are summarized. It is firstly put forward that soft regulation of inflammatory immune responses ( SRIIR) is a new direction of discovery and development of new drugs for the treatment of IIR related diseases.
4.Comparative study of spray characteristics of domestic and foreign nasal spray delivery devices for live attenuated nasal influenza vaccine
Chinese Journal of Biologicals 2023;36(11):1291-1296
Objective To compare the spray characteristics of domestic and foreign nasal spray delivery devices for live attenuated influenza vaccine(LAIV). Methods The particle size distribution(DV10,DV50 and DV90),the proportion of droplets smaller than 10 μm and Span of atomized particles of two brands of nasal spray delivery devices at home and abroad were measured by laser diffraction method,the spray pattern[maximum diameter(D_(max)),shortest diameter(D_(min))and ovality(D_(max)/D_(min))]and spray geometry(spray angle and width)were detected by Spray view,and the comparative analysis was performed. Results There was no significant difference in DV10,DV50,DV90 particle size distribution,proportion of droplets smaller than 10 μm and Span of atomized particles between the two kinds of domestic and foreign nasal spray delivery devices[F-values of Levene's test for equality of variances were 0. 622,0. 135,3. 067,0. 212 and 0. 058,P-values were0. 434,0. 714,0. 085,0. 647 and 0. 810,and significance(two-tailed)values of equal variances assumed were 0. 439,0. 228,0. 281,0. 539 and 0. 910,respectively];D_(max),D_(min)and ovality of the spray patterns showed no significant difference[F-values of Levene's test for equality of variances were 2. 102,2. 666 and 0. 514,P-values were 0. 158,0. 114 and0. 479,and significance(two-tailed)values of equal variances assumed were 0. 651,0. 407,and 0. 160,respectively];The geometric mean ratios of spray angle and width were 0. 92 and 0. 91,respectively,which ranged from 0. 90 to 1. 11.Conclusion Both the domestic and foreign nasal spray delivery devices meet the delivery requirement of the nasal spray LAIV,which can be used for the delivery of nasal spray vaccines and drugs.
6.Investigation and analysis on anti-infective administration in out-patients of our hospital
Chinese Journal of Primary Medicine and Pharmacy 2009;16(1):58-60
Objective To investigate the use of anti-infective drugs in outpatients of our hospital, and to pro-mote rational administration in clinic. Methods Collecting the prescriptions of out-patient during June 2007 in our pharmscy,then statistically analyze the anti-infective drugs information in combination with adverse drug reaction (ADR) reports. Results The percentage of prescriptions was 45. 8%, the average amount of the prescriptions was 62. 56 yuan,the cost of anti-infective drugs accounted for 41.8% ,prescriptions of combined use and injection were 39.5% and 37.2% ,the ratio of ADR was 80. 6% ,irrational administration accounted for 10. 8%. Conclusion The use of anti-infective drugs in our prescriptions of out-patients has some problems, but rational use is the main trend in our hospital.
7.The roles of amyloid βprotein in neurovascular unit injiny
International Journal of Cerebrovascular Diseases 2009;17(12):926-930
The deposition of amyloid β-protein (Aβ is the key pathological basis of cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD). The current studies emphasis that the stability of internal environment between cells of the neurovascular unit is the key to maintain normal brain function. This article reviews the relationship between the Aβand the neurovascular unit injury, and we expect to provide some new ideas for the clinical prevention and treatment of CAA and AD.
8.Retrospective analysis of renal anemia variability on the patients with chronic kidney disease
Clinical Medicine of China 2015;31(5):394-397
Objective To investigate the effect of renal anemia variability on the progression of renal function in patients with chronic kidney disease and hemoglobin variability on the incidence of cardiovascularevents,mortality and re-hospitalization rate.Methods one hundred and twenty-three patients with chronickidney disease with stage Ⅲ-Ⅴ were enrolled in this study.The information of hemoglobin variability,creatinineclearance rate (Ccr),renal function,the incidence of cardiovascular events,mortality and rehospitalization rate,the incidence of cardiovascular events,mortality and rehospitalization rate were recorded and analyzed.ResultsThe change of hemoglobin level was (20.6 ± 10.7) g/L and Ccr change level was (16.3 ± 4.1) ml/min inpatients,and the pearson correlation coefficient was 0.82.Multiple covariance analysis showed that Ccr increaselevel was higher in CKD Ⅲ-Ⅴ period patients with hemoglobin fluctuations than that of hemoglobin stabilitypatients after adjusting smoking history,blood pressure,24 h urinary protein quantitative factors (F =7.6,9.1,4.3;P<0.05).The incidence of cardiovascular events in patients,mortality,rehospitalization rate of hemoglobinwave group were higher than those of hemoglobin stabilizing group(x2 =26.9,5.1,10.6,P<0.05 or P<0.01).Conclusion The fluctuation of hemoglobin is able to aggravate quickly of renal function development,increasethe incidence,mortality and rehospitalization rate of cardiovascular events.
9.Medical Ethics Education New Path under the Academy System Mode for College Medical Students---Taking Xi′an Jiaotong University the Acadeny System Mode As an Example
Chinese Medical Ethics 2015;(4):520-522
The authors discussed ancient academy system in our country and foreign college education environment and characteristic analysis, combined with Xi′an Jiaotong university academy system student management pattern, from the college general education, the implementation of students′comprehensive ability promotion plan, build undergraduate edu-cationsecond classroom, create a harmonious community and college student life characteristic culture, medical ethics education for medical students explore a new path.
10.The clinical analysis of recombinant human endostatin hormone combined with transcatheter arterial chemoembolization of primary hepatocellular carcinoma for 52 patients
Chinese Journal of Postgraduates of Medicine 2014;37(17):26-29
Objective To study the effect of recombinant human endostatin hormone combined with transcatheter arterial chemoembolization (TACE) for the treatment of primary hepatocellular carcinoma (HCC).Methods Fifty-two primary HCC patients were divided into combined group (26 patients) and control group (26 patients) by random digits table method.The patients in combined group received TACE and recombinant human endostatin hormone added in embolism emulsion.The recent curative effect,level of serum vascular endothelial growth factor (VEGF),adverse reactions,recurrence rate and survival rate were compared between two groups.Results The response rate(RR) and clinical benefit rate(DCR) in combined group were 57.69%(15/26),84.62%(22/26),in control group were 34.62%(9/26),73.08%(19/26),there were significant differences (x2 =5.237,P < 0.05 ; x2 =4.284,P < 0.05).The 7th,14th,28th day after TACE,the level of VEGF in two groups was first increased and then a downward trend,the difference were statistically significant (P < 0.05).The level of VEGF in combined group was significantly lower than that in control group (P< 0.05).The follow up rate was 94.23%(49/52),the 1-year and 2-year recurrence rate in combined group was significantly lower than that in control group (P< 0.05).The 2-year and 3-year survival rate in combined group was significantly higher than that in control group (P < 0.05).Conclusion With TACE plus recombinant human endostatin hormone can effectively inhibit the increase of serum VEGF level,improve curative effect and disease control rate,reduce tumor recurrence and improve survival rate.