The effect of radiation therapy, either alone or combined with surgery or chemotherapy is accepted well in the treatment of metastatic carcinoma, multiple myeloma, reticulum cell sarcoma and Ewing's sarcoma. But its effect on osteosarcoma and chondrosarcoma is less clear. The authors reviewed 90 patients treated with radiation therapy, 62 cases with primary bone tumor and 28 cases with multiple myeloma, from 1969 to 1988. There were 20 Ewing's sarcoma, 12 osteosarcoma, 12 chondrosarcoma, 9 Histiocytosis-X and 3 reticulum cell sarcoma among 62 primary bone tumors. And 40 patients with more than three months follow-up were analyzed for the primary response of tumor three months after radiation therapy and the long term effect of the radiation therapy. When the radiation therapy was done alone, the primary response was poor in osteogenic sarcoma, chondrosarcoma, Ewing's sarcoma and reticulum cell sarcoma. But with the multimodal therapy, the primary response was rslatively good in reticulum cell sarcoma and chondrosarcoma. In 15 patients, more than one year follow-up was done. The status of these patients at the last follow-up was poor in all cases trearted with radiation therapy alone than the multimodal therapy except Histiocytosis-X. In multiple myeloma, the effect of radiation therapy for the relief of pain was analyzed. There were complete relief of pain in 14.3%, partial relief in 71.4% and no relief in 10.7%.
Chondrosarcoma ; Drug Therapy ; Follow-Up Studies ; Histiocytosis, Langerhans-Cell ; Humans ; Lymphoma, Non-Hodgkin ; Multiple Myeloma ; Osteosarcoma ; Sarcoma, Ewing

No abstract available.

No abstract available.

No abstract available.

No abstract available.
Esophageal and Gastric Varices*

The cause of pemphigus vulgaris is autoimmune. The serum containes antibodies against the intercellular substance of stratified epithelium, as demonstrated by means of immunofluorescent staining. Therefore antigen-antibody reaction takes place in the intercellalar spaces of squamous epithelium and leads to acantholysis. The association of pemphigus with malignant conditions was frequently reported. Thus there is now increasing evidence of an association between malignaney and the production of pemphigus antibodies by a tumor itaelf. By the evidence that pemphigus is autoimmune disease, it is used to treat with corticosteroid and immunosuppressive drugs, such as methotrexate. Very high doses of corticosteroid appear to he necesaary for an adequate control of the disease. Even though large doae repersents an effective treatment of pemphigus vulgaris, side effects from thia form of therapy have heen quite significant. Two cases of pemphigus vulgaris are reported. .First patient, a 33 year-old housewife, with flaccid bullae and rupture to form erosions of 3 months duration especialIy on buccal mueosa and genitlia. Second patient, a 66 year-old female, with above skin lesions of 6 months duration on buccal mucosa and whole body. Clinically and histopathologically their eruptions were consistent with pemphigus vulgaris. Large initial dose of predniaolone was employed in these treatment. These patients were improved with treatment prednisolone. Prednisolone therapy gave rise to a large numbar of side effects of varying degrees of severity, such as iatrogenic diabetea mellitus, oral candidiasis, hypokalemia, and pychosis etc. At admission 57days, first case complained of lower abdominal pain and tenderness. At this point it was found clinically that the mass on vaginal vault is present. Punch biopsy was p rformed and confirmed epidermoid carcinoma poorly differentiated (stage V). Cystoscopy showed tumor mass of cervix with extension to bladder posterior wall. We advised. External radiation therapy for carcinoma for about 5 weeks (5,000 Rads) but hopeless she was discharged. Second. Patient was much improved without recurrence. Side effects of prednisolone were also controlled.
Abdominal Pain ; Acantholysis ; Adult ; Aged ; Antibodies ; Antigen-Antibody Reactions ; Autoimmune Diseases ; Biopsy ; Candidiasis, Oral ; Carcinoma, Squamous Cell ; Cervix Uteri ; Cystoscopy ; Epithelium ; Female ; Humans ; Hypokalemia ; Methotrexate ; Mouth Mucosa ; Pemphigus* ; Prednisolone ; Recurrence ; Rupture ; Skin ; Urinary Bladder

Pretibial myxedema is a rare condition whieh may occur following the active or treated hyperthyroidism. The preeise cause of pretibial myxedema is not known, but it is now established the Long Acting Thyroid Stimulator(LATS) is 7S-gammaglobulin, that it is present in the serum of 80% of patients with hyperthyroidism and that its activity is as being an autoantibody against a thyroid antigen, retroorbital tissues and in the skin. A 28-year old pregnant housewife was well until age 24 when she developed hyperthyroidism with swelling of the thyroid gland, exopbthalmos and clubbing of the fingers. She was treated with subtotal thyroidectomy 2 years ago at other clinic. The skin lesions revealed circumscribed, firm, and elevated nodules with excess hair growth on shin and dorsum of feet since their onset of one and half years to visit to our hospital. The hiatologic findings showed considerable amounts of mucin especially in the midportion of the dermis. The leaions were improved by the local application of 0.01% Fluocinolone acetonide(Synalar') ointment with occlusive dressing technique.
Adult ; Dermis ; Fingers ; Foot ; Hair ; Humans ; Hyperthyroidism ; Mucins ; Myxedema* ; Occlusive Dressings ; Skin ; Thyroid Gland ; Thyroidectomy

No abstract available.
Pyelonephritis*

No abstract available.
Basophils* ; Humans*

Abnormalities of the short arm of chromosome 12 are relatively common in childhood ALL. Approximately 5~7% of children with ALL have cytogenetic evidence of a translocation involving 12p, whereas 3~5% have deletions which suggest the presence of a tumor suppressor gene at this location. Through the use of sensitive molecular techniques, 12p or 12p 12~13 loss of heterozygosity (LOH) has been demonstrated in approximately 25 oyo of childhood ALL cases. FISH mapping has detected a minimum region of overlap for the 12p deletions between the TEL(ETV6) and CDKN1B(KIP1) geness). Recently, chromosomal translocations involving the TEL gene at 12p13 have been cloned in several hematopoietic disorders. In ALL cells with thet(12;21)(p13;q22), the 5' part of TEL is fused with the AML1 gene. Abnormalities of 12p, especially the t(12 ; 21), are more reliably detected by FISH than by classical cytogenetics because the translocated portions 12p and 21q are virtually identical cytologically. When FISH was combined with Southern blotting and RT-PCR, the t(12;21) was identified as a recur-ring chromosomal abnormality in 16~25% of childhood B-lineage ALL. Despite the identification of the fusion partners in the t(12;21), the actual function of the TEL-AML1 and AML1-TEL fusion proteins in promoting malignant transformation is unclear. Whether the TEL-AML1 fusion alone is necessary and sufficient for malignant transformation in ALL and whether TEL inactivation has a role in leukemogenesis is currently unknown. Loss of the CDKN2(p16) gene at 9p21 is a common genetic abnormality in ALL and a variety of other malignancies. Homozygous CDKN2 deketions have been deteced in approximate 15% of B-lineage ALL and 75% of T-lineage ALL cases. The p16 protein functions as an inhibitor of cyclin-dependent kinase 4, and normally acts to stop cell cycle progression. Whether loss of p16 alone is necessary and sufficient for malignant transformation in childhood ALL has not been determined.
Arm ; Blotting, Southern ; Cell Cycle ; Child ; Chromosome Aberrations ; Chromosomes, Human, Pair 12 ; Clone Cells ; Cyclin-Dependent Kinase 4 ; Cytogenetics ; Genes, Tumor Suppressor ; Humans ; Loss of Heterozygosity ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Translocation, Genetic