Breast Neoplasms ; etiology ; genetics ; pathology ; Chromosome Aberrations ; Comparative Genomic Hybridization ; Epithelial Cells ; pathology ; Female ; Fibroadenoma ; genetics ; Humans ; Loss of Heterozygosity ; Phyllodes Tumor ; etiology ; genetics ; pathology ; Stromal Cells ; pathology

Animals ; Humans ; Learning ; drug effects ; Memory ; drug effects ; Metals ; toxicity ; Nervous System ; drug effects

A drill protector which can lock the drilling depth was designed, which is easy and safe.
Equipment Design ; Fracture Fixation ; instrumentation ; Surgical Instruments

OBJECTIVE:To establish a method for the contents determination of 5 coumarins in sulphur-fumigated and no sul-phur-fumigated Glehnia littoralis,and investigate the effect of sulphur fumigation on the coumarins in G. littoralis. METHODS:HPLC was performed on the column of Hypersil ODS C18 with mobile phase of acetonitrile-0.1% phosphoric acid (gradient elu-tion)at a flow rate of 1.0 ml/min,detection wavelength was 295 nm,column temperature was 30 ℃,and the volume was 20 μl. RESULTS:The linear range was 0.121 5-12.15 μg/L for psoralen,0.389-38.9 μg/L for xanthotoxin,0.055-5.5 μg/L for bergapten, 0.070 5-7.05 μg/L for imperatorin and 0.092 5-9.25 μg/L for isoimperatorin(r≥0.999 7);RSD of precision test was lower than 1.0,RSDs of reproducibility and stability tests were lower than 3.0;recovery was 98.01%-101.97%(RSD<3.0%,n=6). CON-CLUSIONS:The content of coumarins in G. littoralis was obviously decreased after sulphur fumigation. the method is simple and accurate,and canbe used for the quality control of sulphur-fumigated and no sulphur-fumigated G. littoralis.

Objective To explore the effect of clinical application of self-starting devices in patients after major abdominal surgery. Methods From January 2007 to June 2009, 90 patients with major abdominal surgery were randomly divided into the observation group and the control group with 45 patients in each. The observation group using self-starting devices 6 hours after surgery, the control group used the traditional approach to sit and lie. The effect of the two groups was compared. Results Significant difference existed in recovery of bowel movement, wound healing and incidence of pressure sore between the two groups. Conclusions Application of self- starting devices in patients after major abdominal surgery can promote recovery of bowel movement and wound healing and prevent incidence of pressure sore, so that patients can recover early.

Curcumin,a polyphenol compound,is a bioactive constituent extracted from the roots of the perennial herb Curcuma longa L.It has antioxidant,anti-inflammatory,anti-infective,heart protective and anti-tumor properties.Recent research has shown that curcumin can exert neuroprotective role in cerebral ischemia via the mechanisms of antioxidative stress,antiapoptosis,anti-cerebral edema,and anti-inflammation.This article reviews the neuroprotective mechanisms of curcumin in cerebral ischemia.

In 1963, we treated 6 cases of acute radiation sickness (200-8,000 rad) resulted from an accidental uneven 60Co ?-ray irradiation; two of them died of intestinal type within two weeks. Four cases survived and one of them recovered from septicemic shock. Loss of hair, systemic infection, high fever and bleeding occurred in 5 patients. The essential therapeutic measures were strict isolation, preventive treatment with antiinfection drugs, fresh blood transfusion and sometimes infusion of blood formed elements. Among the survivals 2 received homologous bone marrow transplantation.The general conditions of 4 patients followed up for a period of 18 years are apparently good with transparent lens, normal thyroid function and immunological reactions, except one who had low serum IgG level. Three of them showed subnormal adrenocortical activity and impairment of sex gland function. A girl patient (400 rad) gave birth to 2 children one of which has retarded intellectual development. Serial EEG changes occurred only in those received high cranial doses. In all the cases persistence of chromosome aberration in peripheral lymphocytes was observed. With high doses (above 10,000 rad) remote regional effects led to amputation of one leg in one patient and pathological fracture of the femur in another.

There are many methods adopted in the treatment of amblyopia.Now many accessory therapies are enhanced instead of classical therapies,such as application of some therapeutic instruments for amblyopia,acupuncture and Chinese traditional medicine. We still suggest treating amblyopia with classical therapies:correction of refractive errors,occlusion and penalization.In this way,we may avoid attending to trifles and neglect the essentials,and miss the opportunity of treatment.(Ophthalmol CHN,2006,15:292-293)

Objective To check the change of endothlins-1(ET-1) and CGRP in the patients with asthma bronchitis.Methods 45 cases of the treatment group and 15 cases of the routine group were detected by radioimmunossay(RIA).Results The contents of ET-1 and CGRP before treatment with dopamine(DP),dobutamine(DOB) and hentolamine(PTL) group were (117.6?7.5)ng/L,(102.1?12.3)ng/L;(112.4?6.5)ng/L,(104.1?10.3)ng/L;(120.6?6.5)ng/L,(99.1?9.3)ng/L,respectively;It was obviously higher than after treatment (69.9?8.6)ng/L,(72.8?17.1)ng/L;(56.9?8.0)ng/L,(68.8?16.1)ng/L;(72.0?9.0)ng/L,(67.8?15.3)ng/L(P