1.Management of maxillofacial injuries in bear mauling cases: a review of 20 cases.
Indu Bhusan KAR ; Prashant Dilip CHOPDA ; Niranjan MISHRA ; Alok Kumar SETHI ; Bikas Ranjan MAHAVOI
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2016;42(1):13-19
OBJECTIVES: As the craniofacial and neck regions are prime areas of injury in bear attacks, the careful management of soft and hard tissue injuries and selection of reconstructive options is of the utmost importance. This study will review the incidence and patterns of bear mauling in eastern India reported to our department and the various modalities used for their treatment over a period of 7 years. It also documents the risks of infection in bear mauling cases and the complications that have occurred. MATERIALS AND METHODS: Twenty cases were treated over the study period. Cases were evaluated for soft and hard tissue injuries including tissue loss and corresponding management in the craniofacial region. Cases were also evaluated for other associated injuries, organ damage and related complications. RESULTS: Various modalities of treatment were used for the management of victims, ranging from simple primary repairs to free tissue transfers. Simple primary repairs were done in 75% of cases, while the management of the injured victims required reconstruction by local, regional or distant flaps in 25%. Free tissue transfers were performed in 15% of cases, and no cases of wound infection were detected in the course of treatment. CONCLUSION: Knowledge of various reconstructive techniques is essential for managing maxillofacial injuries in bear mauling cases. Modern reconstructive procedures like free tissue transfer are reliable options for reconstruction with minimal co-morbidity and dramatic improvement in treatment outcomes.
Free Tissue Flaps
;
Incidence
;
India
;
Maxillofacial Injuries*
;
Neck
;
Reconstructive Surgical Procedures
;
Wound Infection
2.The phytochemical, biological, and medicinal attributes of phytoecdysteroids: An updated review.
Niranjan DAS ; Siddhartha Kumar MISHRA ; Anusha BISHAYEE ; Eunüs S ALI ; Anupam BISHAYEE
Acta Pharmaceutica Sinica B 2021;11(7):1740-1766
The phytoecdysteroids (PEs) comprise a large group of biologically-active plant steroids, which have structures similar to those of insect-molting hormones. PEs are distributed in plants as secondary metabolites that offer protection against phytophagus (plant-eating) insects. When insects consume the plants containing these chemicals, they promptly molt and undergo metabolic destruction; the insects eventually die. Chemically, ecdysteroids are a group of polyhydroxylated ketosteroids that are structurally similar to androgens. The carbon skeleton of ecdysteroids is termed as cyclopentanoperhydro-phenanthrene with a