Objective To establish a nomogram prediction model of hyperuricemia(HUA)onset risk in overweight and obese children and adolescents in order to provide reference for the prevention and treatment of HUA in this population.Methods The clinical data of 1 410 overweight and obese children and adolescents aged 6-17 years old visiting in this hospital from September 2021 to August 2022 were retrospectively analyzed.A total of 987 overweight and obese children and adolescents were randomly extracted according to a ratio of 7:3 to establish the model,and the remaining 423 cases were validated internally.Referring to the definition of high uric acid in"Zhu-futang Practical Pediatrics",the subjects were divided into high uric acid group and non-high uric acid group.The logis-tic regression analysis was used to analyze the influencing factors of HUA in overweight and obese children and adoles-cents.The nomogram model was constructed by using the R language.The area under the receiver operating character-istic(ROC)curve(AUC),decision analysis curve(DIC),clinical impact curve(CIC)and C-index were used to evalu-ate the predictive ability of the model,and the Bootstrap repeated sampling method(taking samples for 1000 times)was used for internal validation of the model.Results The results of multivariate analysis showed that the age(OR=2.324,95％CI:1.155-4.672,P=0.018),gender(OR=0.456,95％CI:0.256-0.810,P=0.007),triglycerides(OR=3.775,95％CI:2.321-6.138,P＜0.001),blood calcium(OR=26.986,95％CI:3.186-228.589,P=0.003)and blood creatinine(OR=1.047,95％CI:1.026-1.070,P＜0.001)were the influen-cing factors of HUA in overweight and obese children and adolescents.AUC of the ROC curve of the model was 0.840,the sensitivity was 0.786,the specificity was 0.762,the Youden index was 0.548,and the C-index was 0.840.The risk probability of DC A was 0.1-0.8,the net benefit rate of both models was＞0,AUC of ROC curve in the internal verification was 0.871.Conclusion The constructed nomogram in this study has a good predictive efficiency for the onset risk of HUA in overweight and obese children and adolescents,and may provide reference for the early diagnosis and treatment of this population.

BackgroundCompliance of functional exercise has considerable impact on the effectiveness of postoperative rehabilitation among patients with breast cancer. Both symptom burden and hope level of patients are in relation with the compliance mentioned above， but there is limited evidence for the relationship among the three in patients after breast cancer surgery. ObjectiveTo explore the pathway of hope level between symptom burden and functional exercise compliance in patients after breast cancer surgery， with intention to provide references for improving their functional exercise compliance. MethodsFrom March 26 to December 9， 2023， 312 patients who received breast cancer surgery in a tertiary grade A hospital in Sichuan Province were selected as the study objects. Investigation was conducted by adopting scales including the Chinese version of the M. D. Anderson Symptom Inventory （MDASI-C）， the Chinese version of the Herth Hope Scale （HHS-C） and the Functional Exercise Compliance Scale among breast cancer patients after discharge. Pearson correlation analysis was used to examine the correlation among each scale score. Model 4 from the macro program Process of SPSS 25.0 was used to analyze the pathway of hope level between symptom burden and functional exercise compliance. ResultsA total of 308 patients （98.72%） after breast cancer surgery completed effective questionnaire survey. As results showed， MDASI-C score was negatively correlated with scores of HHS-C and functional exercise compliance （r=-0.202， -0.279， P<0.01）， and HHS-C score was positively correlated with score of functional exercise compliance （r=0.453， P<0.01）. The hope level acted as pathway between symptom burden and functional exercise compliance in breast cancer patients after surgery， and the effect value was -0.083 （95% CI： -0.139~-0.009）， accounting for 29.74% of the total effect. ConclusionThe symptom burden of breast cancer patients after surgery can affect their compliance of functional exercise directly and can also indirectly affect the compliance through the level of hope. ［Funded by Nanchong Social Science Research "14th Five-Year Plan" 2022 Annual Project （number， NC22B301）］