Aged ; Calcinosis ; complications ; Heart Aneurysm ; complications ; Heart Ventricles ; Humans ; Male ; Thrombosis ; complications

Objective To explore the clinical value of video-assisted thoracoscopic mediastinal tumor resection.Methods The clinical data of 32 patients(observation group) who performed video-assisted thoracoscopic mediastinal tumor resection were retrospectively analyzed,compared them with 53 patients with mediastinal tumor who underwent traditional thoracotomy (control group).The clinical outcomes including operation time,intraoperative blood loss,chest drainage duration,postoperative hospital stay,postoperative complication and postoperative analgesia drug application were compared between two groups.Results No perioperative death was observed in two groups.There were no statistical difference in operation time between two groups [(121.9 ± 41.2) min vs.(141.7 ± 35.2) min] (P ＞ 0.05).The observation group was significantly better in the intraoperative blood loss [(116.0 ±53.2) ml],chest drainage duration [(5.2 ± 1.2) d],postoperative hospital stay [(8.5 ± 1.3) d],postoperative analgesia drug application [(0.8 ± 0.7) times],postoperative comolication (3 cases),than those of the control group [(147.2 ± 45.2) ml,(6.8 ± 2.2) d,(11.2 ± 2.4) d,(2.1 ± 0.9) times,15 cases].There were statistical differences between two groups (P ＜0.05).Conclusion Complete video-assisted thoracoscopic mediastinal tumor resection is a valuable way in the treatment of mediastinal tumor,rapidly recovery and less postoperative complication.

Drugs, Chinese Herbal ; adverse effects ; Humans ; Nephritis ; chemically induced ; prevention & control

Objective To observe the bone mineral density(BMD)in type 2 diabetic women and discuss the methods for evaluation of BMD.Methods BMD was measured by dual-energy X-ray absorptiometry(DEXA)at skeletal regions of supine and lateral spine,left femur neck and left hip in 484 type 2 diabetic women and 868 healthy women.The relation of BMD of healthy women in skeletal regions with age changes was found to fit a cubic regression model.Results The peak BMD of lateral spine and hip appeared at 25-34 and 35-44 years old respectively.BMD in diabetic women was not different from age-matched healthy women.The BMD values of the different age stages in diabetic women showed no difference(P>0.05)as compared with healthy women,and decreased with the age increase.The numbers of damaged bone sites were increased with the age increase.The BMD difference values between peak value and values of different age stages showed no difference between diabetic and healthy women groups(P>0.05).Conclusion The changes of BMD in type 2 diabetic women show no difference from age-matched healthy women.And in both diabetic and healthy women,BMD decreases with age increasing.

This paper explains the research status of chemotherapy sensitivity test in three aspects of history of development, specific methods and clinical application. Chemotherapy sensitivity test is an important way to achieve individual treatment of cancer, after more than 60 years, there are two major categories(in vivo method and in vitro method) of more than 10 kinds of methods. The basic steps of sensitivity test inelude culture of primary tumor cells, chemotherapy drugs mixed, the reaction mixture, observing the results of detection and analysis of indicators. This paper focuses on basic principles, main steps and characteristics of six methods, such as the renal capsule of nude mice model of human cancer, the difference between staining cell, tetrazolium salt colorimetric, adenosine triphosphate based bioluminescence tumor chemosensitivity assay, collagen gel embedded culture method and targeting molecule sensitivity assay. Through the results of several clinical trials, it can be seen that chemotherapy under the guidance of drug sensitivity test significantly improved more than experience chemotherapy in efficient rate, median progression-free survival time, survival time, clinical complete remission rate, pathological complete remission rate, etc.

OBJECTIVETo study the reliability and validity of Chinese version of International Physical Activity Questionnaire (IPAQ) and to provide an instrument for physical activity measurement in Chinese-spoken population.

METHODSTest-retest reliability was systemically assessed in 94 participants sampled from college students. Questionnaires were completed twice with a three-day interval. The validity was established in 39 volunteers by Caltrac accelerometer monitoring and 24-hour activity recording for seven consecutive days.

RESULTSBoth long vision (LV) and short vision (SV) had intraclass correlation coefficients above 0.7 for physical activity. The total energy expenditure measured by LV, SV and PA records were 264.5 +/- 260.9, 185.4 +/- 128.9 (compared with activity records, P < 0.05) and 250.5 +/- 141.2 MET-min/d respectively. Energy expenditure of moderate physical activity were 81.7 +/- 165.4, 32.0 +/- 42.5 (compared with activity record, P < 0.05) and 61.3 +/- 72.0 MET-min/d. Caltrac accelerometer was moderately correlated with LV (r = 0.50) and SV (r = 0.63) while SV measured total daily energy expenditure was lower than activity records. When participants were categorized into two groups according to their time spent in physical activity above or below the target level, proportions of agreement of questionnaires and 24-hour activity records were high, including vigorous physical activity above 90% and moderate physical activity above 70%. LV, SV and activity records were measured during sedentary condition at an approximate level.

CONCLUSIONSBoth LV and SV of IPAQ appeared to have acceptable reliability and validity, compared to other physical activity instruments that were used in various large epidemiological studies. The total or physical energy expenditures were similar between LV and activity records. For activity levels, the proportion of agreement were similar between activity records and LV or SV. However, SV underestimated the energy expenditure of total and moderate physical activity.

Adult ; China ; Exercise ; Female ; Humans ; Internationality ; Language ; Male ; Reproducibility of Results ; Surveys and Questionnaires ; standards

Objective To study the effects of Danhong Granule on blood rheology of blood stasis rats,and further to investigate the mechanism of promoting blood circulation and removing blood stasis.Methods 60 SD rats were selected and randomly divided into 6 groups,namely,normal control group,model group to the capacity of 0.5％ sodium carboxymethyl cellulose (CMC-Na),Danhong granules in high dose group (3 g/kg),Danhong granules dose group(1.5 g/kg),Danhong granules low dose group(0.75 g/kg),and compound Danshen dripping pill group(3 g/kg).Each group received gastric lavage at 1 ml/kg volume,1/d,for 7 days.After the last administration,the rat model of blood stasis was reproduced by subcutaneous injection of high dose epinephrine with ice water bath method.The effects of Danhong granules on blood rheology of blood stasis model rats were studied.Results Danhong granules in high dose group and compound Danshen dripping pills could reduce blood stasis model rats in blood viscosity (high shear,cut and low cut values were:Danhong granules in high dose group were(5.69±0.16)mPa·s,(6.97±0.48)mPa·s,(22.56±1.69) mPa·s; Compound Danshen Dropping Pill group (5.71 ± 0.24) mPa·s,(7.04 ± 0.51) mPa·s,(22.63 ± 1.64) mPa·s,plasma viscosity respectively:Danhong granules in high dose group were (1.43 ±0.03)mPa·s,compound Danshen dripping pill group(1.42±0.03)mPa·s,RBC (hematocrit value were:Danhong granules in high dose group were (0.42± 0.027) L/L,compound Danshen dripping pill group (0.41 ± 0.032) L/L; Danhong granules dose group could significantly lower the blood stasis model rats in blood viscosity (high,low cut)value (5.95 ± 0.37) mPa·s,(23.45 ± 1.57) mPa·s,plasma viscosity(1.47 ± 0.02)mPa·s and RBC hematocrit value (0.48 ± 0.029) L/L low dose group; Danhong granules low dose group could reduced blood stasis model rats obviously in blood viscosity (high shear,cut and low shear),plasma viscosity and hematocrit values of RBC [respectively:the whole blood viscosity in(7.15±0.41)mPa · s,(7.86±0.36)mPa · s,(28.68±1.69)mPa · s,(1.67±0.03)mPa · s,(0.50±0.033)L/L].Conclusion Danhong Granule can reduce the blood stasis model rats in blood viscosity (high shear,cut and low shear),plasma viscosity and hematocrit value of RBC,by activating blood circulation,removing blood stasis and improving blood rheology.

Cancer metastasis is the most dangerous stage of tumorigenesis and evolution, the primary cause of death in cancer patients. Clinically, more than 60% of cancer patients have found metastasis at the time of examination. Modern medicine has made significant progress on the mechanisms of cancer metastasis in recent years, from the simple "anatomy and machinery" theory forward to the "seed and soil" theory, then to the "microenvironmental" theory and the "cancer stem cell" theory. The emerging "cancer stem cell" theory successfully explains phenomenon such as tumor genetic heterogeneity, anoikis resistance, tumor dormancy, providing more new targets and ideas for the diagnosis and treatment of cancer metastasis.
Animals ; Humans ; Medicine ; methods ; Neoplasm Metastasis ; Neoplasms ; drug therapy ; pathology

ZJ-XD-I multifunctional internal sterilization machine for medical instrumentation is applied in medical instrumentations with circulatory loop such as anesthetic machine and respirator. The machine can generate ozone and hydrogen peroxide, and then the two gases are mixed and introduced into the internal loop to eliminate adnexed hydrogen peroxide such as the virus and germ, and thus the nosocomial infection due to repeated uses of medical instrumentations. The machine is composed of the gas compression component, atomization unit, gas extraction component, control circuit and the filtrating unit.

Metastasis is one of the main complaints of nasopharyngeal carcinoma. After radiotherapy and chemotherapy, residual and recurrent lymph nodes in the neck are still partially seen. Neck dissection is an important salvage treatment to improve survival and life quality. The present review summarizes the distribution of residual and recurrent lymph nodes, the applications of different salvage surgeries and outcomes.