Humans ; Hypertension ; Sympathetic Nervous System ; metabolism ; pathology

Based on the standard strain-Vibrio parahaemolyticus BJ1.1997, temperature (7?C～43?C) and salinity (0.5%～9.5% NaCl) which affected its growth status was studied with uniform design. The results showed that Logistic equation was optimal in primary models, the second was Gompertz equation, the last was Linear equation, so growth parameters can calculated from Logistic equation. The secondary model was developed by square root models, its r value was 0.9863, the lowest growth temperature was 9.0506?C and the highest growth salinity was 5.93% [the corresponding lowest growth water activity (Aw min) was 0.9227]. Through F test, residual analysis and evaluation by bias factor and accuracy factor, the model can exactly describe the relationship between the growth rate and combined effect of temperature and salinity (water activity).

Drugs, Chinese Herbal ; adverse effects ; Humans ; Nephritis ; chemically induced ; prevention & control

Electrical stimulation is well used in medical therapeutics,but the mechanism still needs to be studied further. This paper applies an electrical stimulator to generate low frequency pulse,which is used to stimulate at the root of the thumb,right on the median nerve. EEGs were recorded before and after the stimulation. Comparing the EEGs changes between the former and latter using power spectral analysis,the effect of low frequency electrical stimulation on human nerve excitability is discussed.

Objective To evaluate the selective angiography and interventional management in nonvariceal gastrointestinal hemorrhage.Methods 94 cases with nonvariceal gastrointestinal hemorrhage were accepted for selective angiography.According the location and cause of hemorrhage finding by angiography,these patients were checked by arterial embolization and/or perfusion of vasoconstrictor substance.Results DSA revealed positive result in 58 cases(61.7%) of 94 cases.Meanwhile,13 cases accepted 99m Tc-labeled erythrocytes nuclear scan,11 cases(84.6%) showed hemorrage.Arterial embolization was carried out in 34 cases,the hemostasis and relapse rate was 91.2% and 8.8% respectively.Besides arterial embolization,8 cases were selected vasopressin infusion,the hemostasis and relapse rate of vasopressin infusion was 75.0% and 25.0% respectively.No severe complication such as intestinal necrosis occurred among the 42 cases with interventional therapy.Conclusion Selective angiography is a valuable method for the diagnosis of the nonvariceal gastrointestinal hemorrhage of unknown reasons.The()~(99m)Tc-labeled erythrocytes nuclear scan is more sensitive than selective angiography in detecting bleeding,however,as to find bleeding location accurately,it was inferior to selective angiography.

Objective To study the writing characteristics and related focuses in brain in patients with Uighur and Chinese agraphia.Methods Aphasia Battery of Chinese (ABC) and Uighur ABC were used to examine the characteristics of speaking and writing. The focues were observed with CT and MRI. Results 67 patients were with agraphia, in which 37 were Uigur and 30 were ethnic Han. Both groups mostly showed aphasic agraphia, the focuses were found in various areas in the brain, and mostly located on the left frontal, parietal, temporal lobes and basal ganglion. Conclusion The characteristics of writing were various with the types of agraphia, but similar between Uighur and Chinese cases with same writing characteristics.Writing behavior relies on the cooperation of the whole neuromechanism.

AIM: To study the effect of SCUBE2 on epithelial-mesenchymal transition (EMT) in colorectal cancer cells and its mechanism .METHODS:The expression of SCUBE2 in human colorectal cancer cell line HCT 116 and normal colonic cell line FHC was detected by real-time PCR and Western blot .HCT116 cells were transfected with GV144-SCUBE2 to over-express SCUBE2, and then the cell viability, migration, and apoptosis were determined by MTT assay , Transwell assay and flow cytometry, respectively.The expression of EMT markers (E-cadherin, vimentin, and Snail),β-catenin, c-Myc and cyclin D1 in the HCT116 cells was analyzed by real-time PCR or Western blot after transfection with GV144-SCUBE2 for 6 h, followed by the stimulation of 10 μg/L recombinant TGF-β1 protein for 48 h.Additionally, the EMT process of HCT116 cells, which were stimulated by TGF-β1, over-expressed SCUBE2, and treated with Wnt/β-cate-nin pathway activator lithium chloride ( LiCl) or inhibitor XAV93920, was analyzed by Western blot .RESULTS: Com-pared with FHC cells , the expression of SCUBE 2 in the HCT116 cells was significantly decreased .The viability and migra-tion ability of the HCT116 cells were suppressed by SCUBE2 over-expression, but the apoptosis was not markedly changed . Elevated expression of SCUBE2 increased E-cadherin expression, and decreased the expression of vimentin, Snail,β-cate-nin, c-Myc and cyclin D1 induced by TGF-β1.Treatment with LiCl blocked but treatment with XAV 93920 enhanced the effects of SCUBE2 on EMT.CONCLUSION:Over-expression of SCUBE2 may inhibit the cell growth and migration , and suppress EMT through Wnt/β-catenin signaling pathway .

OBJECTIVE:To provide reference for prescriptions audit before payment in hospital pharmacy. METHODS:The management measures of prescriptions audit and intervention before payment in our hospital were introduced. 1 200 outpatient pre-scriptions within 1 year before and after management were subjected to a statistical analysis. The effects of prescriptions audit be-fore payment were evaluated through analyzing and comparing qualification rate of prescription and unqualified prescriptions. RE-SULTS:Our hospital adopted a series of measure to realize prescriptions audit and intervention before payment by clinical pharma-cists,such as using information audit system,formulating audit standard,educating pharmacists,establishing audit job system, prescriptions review and feedback system,setting up communication system,etc. Of the total audited 189 665 prescriptions, 14 581(7.69%)failed to audit and 606 prescriptions hadn’t been revised after 1 year management,with effective intervention rate of 95.84%. Compared with before management,the prescription qualification rate increased from 88.83% to 98.67% after manage-ment(P<0.01). The quantity of overdose,inconformity with medical insurance,overload and other conditions reduced to 0. CON-CLUSIONS:It is feasible for pharmacists to audit and intervent prescriptions before payment in hospital pharmacy to improve pre-scription qualification and promote rational drug use in the clinic.

BACKGROUND:Numerous studies have demonstrated that the use of periodontal tissue-guided regeneration technique significantly elevated success rate of immediate technical planting. No significant difference is detected as compared with the delayed planting success rate in the clinic. OBJECTIVE: To compare the clinical effects of immediate implant and delayed implant in the restoration of anterior teeth. METHODS:A total of 100 cases with former dental implants, who had 160 diseased teeth, were enroled in this study. They were divided into experimental and control groups according to the principle of random pairing. In the experimental group, the implant was put into the extraction sockets after minimaly invasive tooth extraction with the use of periodontal guided tissue regeneration technique. In the control group, at 3 months after minimaly invasive tooth extraction, implant was implanted in the sockets. Delayed planting repair of denture in the missing teeth area was performed with the use of periodontal guided tissue regeneration technique. Crown restoration was conducted in both groups at 3 months after implantation. Aesthetics, periodontal pocket depth and implant success rate were compared after repair in both groups. RESULTS AND CONCLUSION: Gingival esthetics score was better at 1, 3, 6 and 12 months after repair in the experimental group than in the control group (P < 0.05). Periodontal pocket depth was less at 1, 3, 6 and 12 months after repair in the experimental group than in the control group (P < 0.05). No significant difference in success rate of implants was detected at 12 months after repair between both groups (P> 0.05). Above findings confirmed that aesthetic effect, treatment cycle, and the health of periodontal tissue were better in the immediate implanting group than in the delayed implanting group. However, no significant difference in success rate was detected between immediate implanting and delayed implanting groups.

BACKGROUND:A large amount of apicocoronal and buccolingual bone resorption occur in alveolar bone after tooth extraction, leading to the distinct shortage of bone mass of alveolar bone in tooth-missing area, which has a certain effect on the stability of early implantation and postoperative aesthetic outcomes and greatly affects the long-term success rate of denture implantation. Therefore, immediate-delayed implantation can shorten the time of repair. OBJECTIVE:To evaluate the effect of implant repair after immediate-delayed implantation and application of guided bone regeneration technique in anterior maxila area. METHODS:Nineteen patients (28 teeth lost) with maxilary anterior tooth loss and labial one-waled bone defects were selected. Twenty-eight OSSTEM implants were implanted at 4 weeks after tooth extraction. Guided bone regeneration technique was applied concurrently in labial bone defect area. The secondary repair was performed after 6 months. RESULTS AND CONCLUSION:The success rate of these 28 implants was 100% at 24 months after denture implantation. The peri-implant bone height loss at 6, 12 and 24 months was 0.1, 0.6 and 0.11 mm, respectively. Red aesthetic scores were satisfactory. Immediate-delayed implantation combined with application of guided bone regeneration technique for treatment of maxilary anterior tooth loss and mild bone defect can restore the height and width of peri-implant bone and acquire stable vertical bone resorption and satisfactory gingival aesthetic outcomes .