More studies are now focusing on vitamin E as an anticancer agent for its good effects in many in-vitro studies. Current studies proposed that vitamin E might be a suitable candidate as an alternative treatment for cancer due to its antioxidant properties. Vitamin E act as an antioxidant by their long-chain polyunsaturated fatty acids, and thus the integrity of membranes in the cells is maintained and consequently retain the bioactivity of the cells. This mini review will focus on the activity of vitamin E as an antioxidant to protect against cancer in in-vitro, in-vivo, and clinical studies. Although most studies reported great outcomes for the anticancer activity of vitamin E, there were some conflicting data. To date, studies on effects of vitamin E are still undergoing where researchers are still debating on the positive and negative effects of vitamin E as an anticancer therapeutic action.

Objective: To evaluate the antioxidant and antiproliferative effect of methanolic bee pollen extract (BPE) of Malaysian stingless bee [Lepidotrigona terminata (L. terminata)] and its synergistic effect with cisplatin (a chemotherapeutic drug) on MCF-7 cancer cell line. Methods: The antioxidant activity of BPE from L. terminata was measured by using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) assay. Antiproliferative activity at different concentrations of BPE and cisplatin was determined through using MTT assay on MCF-7 and L929 cell lines. An interaction effect (synergistic, additive and antagonistic) between BPE and cisplatin was determined by CompuSyn software based on MTT assay data. Results: The EC

Garcinia celebica (G. celebica), an aromatic plant which is domestically planted for fruits and ornamental purposes, is exceptionally rich in important phytochemicals that may contribute to its medicinal properties. The mechanistic basis of cytotoxic action of G. celebica essential oil (EO-GC) in MCF-7, MCF-7/TAMR-1, and MCF-10A cell cultures was explored in this study. The study findings showed that the EO-GC potently inhibited the proliferation of the MCF-7 and MCF-7/TAMR-1 cells by 50% at 37.5 µg/mL and 18.8 µg/mL concentrations, respectively. In contrast, a higher concentration (77.5 µg/mL) of the essential oil was needed to inhibit the MCF-10A cells. These findings demonstrated that the EO-GC possesses selective cytotoxic effects by two-fold and four-fold towards the MCF-7 and MCF-7/TAMR-1 cells, respectively, than the MCF-10A cells. Flow cytometric analysis has proven that the EO-GC can effectively induce apoptotic cell death in the cultured MCF-7 and MCF-7/TAMR-1 cells, while having minimal effect on the MCF-10A cells. Therefore, these preliminary findings may add novel scientific data related to the potential therapeutic efficacy of the ethereal oil derived from G. celebica leaves.