1.Association of IL-1beta gene -31T/C polymorphism with chronic rhinosinusitis.
Nijun CHEN ; Peihua NI ; Changping CAI ; Shili WANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2011;25(5):197-200
OBJECTIVE:
To investigate the relationship between polymorphism of IL-1beta gene 31T/C and chronic rhinosinusitis.
METHOD:
One hundred and twenty-three patients with chronic rhinosinusitis and 239 healthy controls were collected to determine the genotypes by polymerase chain reaction-restriction fragment length polymorphism.
RESULT:
There was significant difference in genotype and allelic frequencies between the CRS and control group (P < 0.05). -31CC genotype was an independent risk factor with CRS (P < 0.05, OR = 1.639). There was no significant difference in TIgE and ECP among these genotypes (P > 0.05).
CONCLUSION
IL-1beta gene 31CC genotype may be an independent risk factor with chronic rhinosinusitis.
Adult
;
Case-Control Studies
;
Chronic Disease
;
Female
;
Gene Frequency
;
Genotype
;
Humans
;
Interleukin-1beta
;
genetics
;
Male
;
Middle Aged
;
Polymorphism, Single Nucleotide
;
Sinusitis
;
genetics
2.The association between genetic polymorphisms of IL-6 and the susceptibility of chronic rhinosinusitis.
Meili ZHANG ; Peihua NI ; Changping CAI ; Nijun CHEN ; Shili WANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2012;26(5):197-204
OBJECTIVE:
To investigate the relationship between the promoter polymorphism of IL6 (-174G > C, -572G > C and -597G > A) and chronic rhinosinusitis (CRS).
METHOD:
The case-control study consisted of 123 patients with CRS and 239 controls from a Chinese Han population from Shanghai. The genotypes of the subjects were determined by polymerase chain reaction-restriction fragment length polymorphism and gene sequencing. Besides, the concentrations of the totle immunoglobulin E (TIgE) and eosinophilic cationic protein (ECP) in the blood were also determined.
RESULT:
The -174G > C and -597G > A polymorphisms were not detected in this study population. Significant differences in genotype and allele frequencies of -572C/G were observed between CRS patients and control groups. In CRS patients, the CC, CG, GG genotype frequencies were 69.1%, 29.3%, 1.6%, C, G allele frequencies were 83.7%, 16.3%. In control group, the genotype frequencies were 55.2%, 42.3%, 2.5%, the allele frequencies were 76.4%, 23.6%, respectively. The -572CC genotype was associated with an increased risk of developing CRS (P < 0.05, OR = 1.932, 95% CI, 1.205-3.097). There was no significant differences in the concentrations of the TIgE and ECP among each genotype.
CONCLUSION
IL-6 gene -572G > C polymorphism is associated with the susceptibility to CRS. CC genotype could be an independent risk factor.
Adolescent
;
Adult
;
Aged
;
Aged, 80 and over
;
Case-Control Studies
;
China
;
Chronic Disease
;
Female
;
Gene Frequency
;
Genetic Predisposition to Disease
;
Genotype
;
Humans
;
Interleukin-6
;
genetics
;
Male
;
Middle Aged
;
Polymorphism, Single Nucleotide
;
Risk Factors
;
Sinusitis
;
genetics
;
Young Adult