Objective To explore the research status and trends of Danggui Shaoyao San-related literature from 2000 to 2023. Methods Danggui Shaoyao San-related research literature were searched in four databases: China National Knowledge Internet (CNKI), VIP Chinese Science and Technology Periodical Database (VIP), Wanfang Database, and SinoMed, with the time period set from January 1, 2000 to December 20, 2023. Duplicate literature was removed using the literature management software NoteExpress, and CiteSpace 6.1. R6 was employed to conduct a visual analysis of the literature. Results A total of 1, 163 articles were included, and the number of publications showed a fluctuating growth trend from 2000 to 2023. The journal with the highest number of publications was Chinese Journal of Experimental Traditional Medical Formulae (39 articles), the most prolific author was Xu Fan (19 articles), and the institution with the most publications was Henan University of Chinese Medicine (10 articles) and Jiangxi University of Traditional Chinese Medicine (10 articles). High-frequency keywords included "clinical application" "chronic pelvic inflammatory disease" "traditional Chinese medicine therapy" ect., and cluster analysis generated 11 labels. Conclusion Research hotspots of Danggui Shaoyao San encompass clinical application, literature textual research, and mechanisms of action, etc. Exploring its mechanisms and targets through network pharmacology and molecular docking technology represents the research trend.