No abstract available.
Nicotine*

No abstract available.
Nicotine*

No abstract available.
Chlorpromazine* ; Nicotine* ; Skin*

No abstract available.
Nicotine* ; Periodontal Ligament*

Tabagism or health is one of important problems for our country, lung cancers are related commonly tabagism. To understand the relation between them, the general review of 9 scientific works, which published in Vietnam medical literature from 1957 to 1995 is made. 1. The rate of lung cancers related tabagism. Before 1993- year of foundation of national program against lung cancers. (n= 629 cases from 1966 to 1991) 61-95% the average 70-80%. After 1993 (n= 935 cases from 1994 to 1995) 75.3 - 78.2% equivalent to the former. Indice of lung cancers in the community is about 60/100,000 habitants 1993. 2. The rate of cigarettes or laos tobacco smoking 9 (water- pipe tobacco): cigarettes smoking 23.0%; laos tobacco smoking 40.0%; both two 70-80%. 3. Tabagism and sex. The majority are male smoker 75 - 90% and 46% are laos tobacco smoking. 4. Number of years and cigattes smoking per day. 5. Lung cancers and type of histology. This relation is not clearly proved, the one: type of histology is related to tabagism except adeno cancer, but another : there is no significative difference with p > 0.05. Conclusion; 70-80% lung cancers in Vietnam are smokers, it is nearly equivalent to developed countries (WHO 80-90%) It is necessary to carry out survey on tabagism in different regions and continue to study profoundly the relation between lung cancers and their types of histology
Lung Neoplasms ; Nicotine

OBJECTIVETo observe the effects of nicotine on the proliferation of odontoblasts and explore the possible mechanism.

METHODSOdontoblasts MDPC-23 were cultured, inoculated and divided into two groups randomly. With no stimuli added for the control group, the experimental group was stimulated by 100 microg/mL nicotine. After 8 hours, 10 micromol/L BrdU was added to label cells at S stage in cell cycle. 24 hours later, odontoblasts were fixed and immunofluorescence staining was performed with specific mouse BrdU antibody. After counterstaining with propidium iodide, BrdU positive cells were arbitrarily scored microscopically by an independent estimation conducted three times, and the corresponding total cell number in the same vision were counted in both groups. BrdU positive cell rates were calculated and compared statistically. At the same time, odontoblasts MDPC-23 were cultured and stimulated by 100 microg/mL nicotine, the dynamic Ca2+ concentration inside the cytoplasm were detected immediately by a confocal laser scanning microscope.

RESULTSThe ratio of S stage cells in the experimental group was 36.3% significantly lower than that (48.2%) in the control group. After the addition of 100 microg/mL nicotine, the Ca2+ concentration inside the cytoplasm rose rapidly, sustained at a high level for a short time and then relapsed gradually.

CONCLUSIONNicotine had inhibitory effects on the proliferation of odontoblasts MDPC-23, which might be related to the increased Ca2+ concentration in the cytoplasm.

No abstract available.
Animals ; Chick Embryo* ; Nicotine*

No abstract available.
Nicotine* ; Tobacco Use Cessation Products*

No abstract available.
Nicotine* ; Tobacco Use Cessation Products*

No abstract available in English.
Animals ; Nicotine* ; Rats* ; Urinary Bladder