1.How You Become Who You Are: A New Concept of Beauty for Plastic Surgery.
Vittoradolfo TAMBONE ; Mauro BARONE ; Annalisa COGLIANDRO ; Nicola DI STEFANO ; Paolo PERSICHETTI
Archives of Plastic Surgery 2015;42(5):517-520
No abstract available.
Beauty*
;
Plastics*
;
Surgery, Plastic*
2.An Integrated Air Monitoring Approach for Assessment of Formaldehyde in the Workplace.
Stefano DUGHERI ; Alessandro BONARI ; Ilenia POMPILIO ; Marco COLPO ; Nicola MUCCI ; Giulio ARCANGELI
Safety and Health at Work 2018;9(4):479-485
The aim of this study is to validate an integrated air monitoring approach for assessing airborne formaldehyde (FA) in the workplace. An active sampling by silica gel impregnated with 2,4-dinitrophenylhydrazine, a passive solid phase microextraction technique using O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine as on-fiber derivatization reagent, an electrochemical direct-reading monitor, and an enzyme-based badge were evaluated and tested over a range of 0.020–5.12 ppm, using dynamically generated FA air concentrations. Simple linear regression analysis showed the four methods were suitable for evaluating airborne FA. Personal and area samplings in 12 anatomy pathology departments showed that the international occupational exposure limits in the GESTIS database were frequently exceeded. This monitoring approach would allow a fast, easy-to-use, and economical evaluation of both current work practices and eventual changes made to reduce FA vapor concentrations.
Chromatography
;
Formaldehyde*
;
Humans
;
Linear Models
;
Occupational Exposure
;
Pathology
;
Silica Gel
;
Solid Phase Microextraction
3.Impact of Pedal Arch Patency on Tissue Loss and Time to Healing in Diabetic Patients with Foot Wounds Undergoing Infrainguinal Endovascular Revascularization
Nicola TROISI ; Filippo TURINI ; Emiliano CHISCI ; Leonardo ERCOLINI ; Pierfrancesco FROSINI ; Renzo LOMBARDI ; Francesca FALCIANI ; Cristiana BAGGIORE ; Roberto ANICHINI ; Stefano MICHELAGNOLI
Korean Journal of Radiology 2018;19(1):47-53
OBJECTIVE: To retrospectively evaluate the impact of pedal arch quality on tissue loss and time to healing in diabetic patients with foot wounds undergoing infrainguinal endovascular revascularization. MATERIALS AND METHODS: Between January 2014 and June 2015, 137 consecutive diabetic patients with foot wounds underwent infrainguinal endovascular revascularization (femoro-popliteal or below-the-knee, arteries). Postprocedural angiography of the foot was used to divide the patients into the following three groups according to the pedal arch status: complete pedal arch (CPA), incomplete pedal arch (IPA), and absent pedal arch (APA). Time to healing and estimated 1-year outcomes in terms of freedom from minor amputation, limb salvage, and survival were evaluated and compared among the three groups. RESULTS: Postprocedural angiography showed the presence of a CPA in 42 patients (30.7%), IPA in 60 patients (43.8%), and APA in 35 patients (25.5%). Healing within 3 months from the procedure was achieved in 21 patients with CPA (50%), 17 patients with IPA (28.3%), and in 7 patients with APA (20%) (p = 0.01). There was a significant difference in terms of 1-year freedom from minor amputation among the three groups (CPA 84.1% vs. IPA 82.4% vs. APA 48.9%, p = 0.001). Estimated 1-year limb salvage was significantly better in patients with CPA (CPA 100% vs. IPA 93.8% vs. APA 70.1%, p < 0.001). Estimated 1-year survival was significantly better in patients with CPA (CPA 90% vs. IPA 80.8% vs. APA 62.7%, p = 0.004). CONCLUSION: Pedal arch status has a positive impact on time to healing, limb salvage, and survival in diabetic patients with foot wounds undergoing infrainguinal endovascular revascularization.
Amputation
;
Angiography
;
Diabetic Foot
;
Foot
;
Freedom
;
Humans
;
Limb Salvage
;
Retrospective Studies
;
Tibial Arteries
;
Wounds and Injuries
4.Liver transplantation for organ failure following multiple locoregional treatments for breast cancer metastasis
Giammauro BERARDI ; Valerio GIANNELLI ; Marco COLASANTI ; Roberto CIANNI ; Roberto MENICONI ; Nicola GUGLIELMO ; Stefano FERRETTI ; Ludovica Di CESARE ; Adriano PELLICELLI ; Guido VENTRONI ; Enrico CORTESI ; Giuseppe Maria ETTORRE
Annals of Hepato-Biliary-Pancreatic Surgery 2024;28(4):516-521
Patients with nonresectable breast cancer liver metastasis (BCLM) face a dismal prognosis. Despite liver transplantation (LT) for metastatic liver tumors having recently shown good results, BCLM represents an absolute contraindication. This study aimed to investigate the potential for long-term survival after LT for BCLMs in a patient experiencing end-stage liver disease, following multiple oncologic treatments. In July 2019, we performed a deceased donor LT on a 41-year-old female with BCLM controlled with human epidermal growth factor receptor 2 targeted therapy, who developed liver failure following multiple locoregional liver-directed treatments. The primary tumor was treated with surgical resection and adjuvant chemoradiation in 2000. The procedure was performed under a protocol approved by the local ethical committee, and by the Italian National Transplant Center. A 12-month treatment with trastuzumab was performed immediately after LT. Immunosuppression following transplantation was undertaken without steroids, and with everolimus. The patient completed 12 months of follow-up without recurrence. Trastuzumab was then withdrawn. Fifteen months after LT, a liver recurrence occurred that was treated with chemotherapy. In October 2021, she developed 2 brain lesions that were treated with stereotactic radiation. The patient is still alive, with a positron emission tomography/computed tomography performed in January 2024 showing no disease. LT for this patient with BCLM of extreme selectivity showed a good clinical outcome. Perioperative systemic treatment and tumor control are necessary. A specific protocol should be discussed within a multidisciplinary team, and with local and national authorities. Even if tumor recurrence occurs, multimodal therapy can control the disease.
5.Liver transplantation for organ failure following multiple locoregional treatments for breast cancer metastasis
Giammauro BERARDI ; Valerio GIANNELLI ; Marco COLASANTI ; Roberto CIANNI ; Roberto MENICONI ; Nicola GUGLIELMO ; Stefano FERRETTI ; Ludovica Di CESARE ; Adriano PELLICELLI ; Guido VENTRONI ; Enrico CORTESI ; Giuseppe Maria ETTORRE
Annals of Hepato-Biliary-Pancreatic Surgery 2024;28(4):516-521
Patients with nonresectable breast cancer liver metastasis (BCLM) face a dismal prognosis. Despite liver transplantation (LT) for metastatic liver tumors having recently shown good results, BCLM represents an absolute contraindication. This study aimed to investigate the potential for long-term survival after LT for BCLMs in a patient experiencing end-stage liver disease, following multiple oncologic treatments. In July 2019, we performed a deceased donor LT on a 41-year-old female with BCLM controlled with human epidermal growth factor receptor 2 targeted therapy, who developed liver failure following multiple locoregional liver-directed treatments. The primary tumor was treated with surgical resection and adjuvant chemoradiation in 2000. The procedure was performed under a protocol approved by the local ethical committee, and by the Italian National Transplant Center. A 12-month treatment with trastuzumab was performed immediately after LT. Immunosuppression following transplantation was undertaken without steroids, and with everolimus. The patient completed 12 months of follow-up without recurrence. Trastuzumab was then withdrawn. Fifteen months after LT, a liver recurrence occurred that was treated with chemotherapy. In October 2021, she developed 2 brain lesions that were treated with stereotactic radiation. The patient is still alive, with a positron emission tomography/computed tomography performed in January 2024 showing no disease. LT for this patient with BCLM of extreme selectivity showed a good clinical outcome. Perioperative systemic treatment and tumor control are necessary. A specific protocol should be discussed within a multidisciplinary team, and with local and national authorities. Even if tumor recurrence occurs, multimodal therapy can control the disease.
6.Liver transplantation for organ failure following multiple locoregional treatments for breast cancer metastasis
Giammauro BERARDI ; Valerio GIANNELLI ; Marco COLASANTI ; Roberto CIANNI ; Roberto MENICONI ; Nicola GUGLIELMO ; Stefano FERRETTI ; Ludovica Di CESARE ; Adriano PELLICELLI ; Guido VENTRONI ; Enrico CORTESI ; Giuseppe Maria ETTORRE
Annals of Hepato-Biliary-Pancreatic Surgery 2024;28(4):516-521
Patients with nonresectable breast cancer liver metastasis (BCLM) face a dismal prognosis. Despite liver transplantation (LT) for metastatic liver tumors having recently shown good results, BCLM represents an absolute contraindication. This study aimed to investigate the potential for long-term survival after LT for BCLMs in a patient experiencing end-stage liver disease, following multiple oncologic treatments. In July 2019, we performed a deceased donor LT on a 41-year-old female with BCLM controlled with human epidermal growth factor receptor 2 targeted therapy, who developed liver failure following multiple locoregional liver-directed treatments. The primary tumor was treated with surgical resection and adjuvant chemoradiation in 2000. The procedure was performed under a protocol approved by the local ethical committee, and by the Italian National Transplant Center. A 12-month treatment with trastuzumab was performed immediately after LT. Immunosuppression following transplantation was undertaken without steroids, and with everolimus. The patient completed 12 months of follow-up without recurrence. Trastuzumab was then withdrawn. Fifteen months after LT, a liver recurrence occurred that was treated with chemotherapy. In October 2021, she developed 2 brain lesions that were treated with stereotactic radiation. The patient is still alive, with a positron emission tomography/computed tomography performed in January 2024 showing no disease. LT for this patient with BCLM of extreme selectivity showed a good clinical outcome. Perioperative systemic treatment and tumor control are necessary. A specific protocol should be discussed within a multidisciplinary team, and with local and national authorities. Even if tumor recurrence occurs, multimodal therapy can control the disease.