1.Effect of nicardipine nitroprusside and enalapril on the survival of random pattern skin flaps in rats.
Han Yong KIM ; Byung Sam KIM ; Gi Young IM ; Sam Yong LEE ; Bek Hyun CHO
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1991;18(6):998-1005
No abstract available.
Animals
;
Enalapril*
;
Nicardipine*
;
Nitroprusside*
;
Rats*
;
Skin*
2.A Clinical Trial on Antihypertensive Effect of Nicardipine Hydrochloride.
Gyo Ik SOHN ; Jue Hong LEE ; Jang Geun PARK ; Suck Hyun YOON ; Yeong Woo SHIN ; Young Kee SHIN
Korean Circulation Journal 1985;15(3):479-482
The antihypertensive effect and side reactions of perdipine was studied in 22 cases of essential hypertension using 20mg 3 times daily regimen for average period of 5 weeks. 1) Average reduction of 20mmHg in systolic and 17mmhg in diastolic pressure was observed and percentile reduction was 11.90% and 14.92%, respectively. The overall effect rate was 81.82%. The blood pressure lowered significantly after 2 weeks of treatment both in systolic and diastolic pressure. 2) There was no significant change in heart rates before and after treatment. 3) No specific side reaction was observed except 1 case in which discontinued the medication because of severe headache and fatigability on the 1st day of medication.
Blood Pressure
;
Headache
;
Heart Rate
;
Hypertension
;
Nicardipine*
3.Use of Nicardipine and Esmolol in the Anesthetic Management for Bilateral Pheochromocytoma: A case report.
Pil Jae LIM ; Hyun Jeong KWAK ; Ho Sung KWAK
Korean Journal of Anesthesiology 2003;44(1):128-131
Pheochromocytoma stems from the chromaffin cell and mostly is located in the adrenal medulla. It is an important cause of secondary hypertension due to correction of hypertension by a resection of the tumor. Because it produces and secretes catecholamine, it bothers anesthesiologists with excessive hypertension, tachycardia and arrhythmia during the anesthetic period. Therefore, anesthetic management is directed to avoid these conditions. We report a case of bilateral pheochromocytoma successfully managed intraoperatively with an infusion of nicardipine and an intermittent esmolol injection.
Adrenal Medulla
;
Arrhythmias, Cardiac
;
Chromaffin Cells
;
Hypertension
;
Nicardipine*
;
Pheochromocytoma*
;
Tachycardia
4.Effect of Nicardipine on Pressor Response to Raised Intracranial Pressure and alpha-Adrenoceptor Agonist.
Journal of Korean Neurosurgical Society 1989;18(1):23-31
The effect of nicardipine was investigated on hypertension due to raised intracranial pressure, pressor response of alpha-adrenoceptor agonists in the dissected thoracic aorta. Intracerebroventricular(icv) and intravenous(iv) nicardipine produced dose-dependent depressor response and bradycardiac effect, especially marked response was observed following iv injection. The pressor response to raised intracranial pressures was potentiated following iv injection of 50 microgram/kg nicardipine but was markedly inhibited following iv 100 microgram/kg injection, and was not affected following icv 50 microgram/kg administration but was markedly inhibited following icv administration of 100-200 microgram/kg nicardipine. The nicardipine inhibited contractile effect of KCI 35 mM in a dose-dependent fashion but did not affect that of Ne and ME. These data suggest that nicardipine caused hypotensive effect by blocking calcium influx in the peripheral vessels and that direct effect of nicardipine on central nervous system involves the hypotensive action. Conclusively, the inhibitory effect of nicardipine on the pressor response to the intracranial pressure elevation may be induced by these two mechanisms.
Aorta, Thoracic
;
Calcium
;
Central Nervous System
;
Hypertension
;
Intracranial Pressure*
;
Nicardipine*
5.Clinical Observation on Antihypertensive Effects of Nicardipine Hydrochloride(Perdipine(R)).
Wang Seong RYU ; Byung Heui OH ; Myoung Mook LEE ; Jung Don SEO ; Young Woo LEE
Korean Circulation Journal 1985;15(4):659-663
The antihypertensive effect of nicardipine was studied in 31 cases of essential hypertension and following results were obtained. 1) Daily dose was 30-60mg for 10 weeks. 2) Mean systolic and diastolic pressure were decreased by 39.5mmHg 921%) and 17.2mmHg(15%) respectively(P<0.005) and in 84% of cases, good or fair control of blood pressure was proved. 3) There was no significant change in heart rates before and after treatment. 4) There were no significant side effects except two cases of mild headache and facial flushing which subsided spontaneously.
Blood Pressure
;
Flushing
;
Headache
;
Heart Rate
;
Hypertension
;
Nicardipine*
6.Nicardipine Augments Local Myocardial Perfusion after Coronary Artery Reperfusion in Dogs.
Journal of Korean Medical Science 2003;18(1):23-26
Nicardipine is a potent coronary and systemic vasodilator without depression of ventricular function. We investigated the changes in local myocardial perfusion (LMP) according to the nicardipine administration after coronary reperfusion in a beating canine model. A Doppler probe was placed around the left anterior descending coronary artery (LAD) and thermal diffusion microprobe was implanted in the myocardium perfused by the exposed LAD. To define the nicardipine effects, we compared the two groups (control group, n=7 vs nicardipine group, n=7). In nicardipine group, 5 microgram/kg/min nicardipine was infused continuously. After the release of the LAD occlusion, LAD blood flow were increased compared to the baseline of both groups. However, there was no difference between groups in the LAD blood flow. The LMP after LAD reperfusion did not recover to the baseline level until 30 min after LAD reperfusion in control group (74%, 52% and 70% at 10, 20 and 30 min after LAD reperfusion, respectively). In nicardipine group, however, the LMP recovered to the baseline level at 20 min (99%), and increased more than the baseline level at 30 min (141%) after LAD reperfusion. Our findings suggest that the nicardipine augments the LMP following the release of a coronary occlusion.
Animals
;
Coronary Circulation/drug effects*
;
Dogs
;
Drug Evaluation, Preclinical
;
Myocardial Reperfusion*
;
Myocardial Reperfusion Injury/prevention & control*
;
Nicardipine/pharmacology*
;
Nicardipine/therapeutic use
;
Vasodilator Agents/pharmacology*
;
Vasodilator Agents/therapeutic use
7.Effects of Nicardipine on Changes of Blood Pressure and Heart Rate during Laryngeal Microscopic Surgery.
Jong Yeon PARK ; Da Huin SHIN ; Yu Mee LEE ; Jai Hyun HWANG ; Pyung Hwan PARK
Korean Journal of Anesthesiology 2004;47(1):48-53
BACKGROUND: Laryngoscopy, tracheal intubation and the suspension laryngoscopy often provoke an undesirable increase in blood pressure and/or heart rate during laryngeal microscopic surgery. Thus, the anesthesiologist's objectives are to maintain sufficient anesthetic depth and to promote rapid awakening. Nicardipine, a direct arterial dilator, can be used to attenuate increasing blood pressure. We investigated the effects of nicardipine on changes of blood pressure and heart rate during laryngeal microscopic surgery. METHODS: Eighty patients of ASA class 1 or 2 scheduled for laryngeal microscopic surgery were randomly allocated into 4 groups. For anesthetic induction, IV propofol 1.5 mg/kg, rocuronium 0.4 mg/kg, and glycopyrrolate 0.2 mg were administered followed by mask ventilation for 5 minutes with isoflurane. One minute before tracheal intubation and suspension laryngoscopy saline, nicardipine 10, 20, or 30microgram/kg was injected in each group. Thereafter we measured blood pressure and heart rate one minute after each procedure. RESULTS: Increases in blood pressure were blunted in the nicardipine 20 and 30microgram/kg group. In the nicardipine 30microgram/kg group, heart rates were significantly increased and facial flushing was observed in two patients. CONCLUSIONS: We suggest that nicardipine 20microgram/kg can alleviate blood pressure increases with little effect on heart rate during laryngeal microscopic surgery. However, although nicardipine 30microgram/kg could blunt blood pressure increases, it produces tachycardia and perhaps overdose.
Blood Pressure*
;
Flushing
;
Glycopyrrolate
;
Heart Rate*
;
Heart*
;
Humans
;
Intubation
;
Isoflurane
;
Laryngoscopy
;
Masks
;
Nicardipine*
;
Propofol
;
Tachycardia
;
Ventilation
8.Effect of Intracoronary Nicardipine on Functional Recovery of Stunned Myocardium in Halothane-Anesthetized Dogs.
Kyung Yeon YOO ; Young Mee CHAE ; Kyeong Hee KIM ; Myung Ha YOON ; Chang Young JEONG
Korean Journal of Anesthesiology 1996;31(2):167-177
BACKGROUND: Myocardial calcium overload during reperfusion may contribute to myocardial stunning. The protective effect of nicardipine against post-ischemic myocardial dysfunction was investigated. METHODS: Twenty-two halothane-anesthetized dogs were subjected to 15 minutes of left anterior descending coronary artery (LAD) occlusion and subsequent 3 hour reperfusion. One group of dogs (n=11) received nicardipine (1 microgram/kg/min) and another group (n=11) received saline (0.5 ml/kg/h) through intracoronary catheter for 1 hour beginning 15 minutes before LAD occlusion. Systolic shortening (%SS) and preload recruitable stroke work slope (Mw), as an index of regional myocardial contractility, and IMP-tau (time constant of myocardial relaxation based on intramyocardial pressure (IMP)) and post-systolic shortening (%PSS), as an index of regional diastolic function, were evaluated. LAD blood flow was measured by Doppler flowmeters as well. RESULTS: Regional systolic as well as diastolic functions during acute myocardial ischemia were similar between the two groups. However, Mw recovered to the baseline value with the onset of reperfusion in the nicardipine group but was significantly decreased throughout the reperfusion period in the controls. After 3 hours of reperfusion, the nicardipine group had recovered 67% of %SS, compared with 20% of the control group. IMP-tau was restored to the baseline value by 60 min of reperfusion in the control group but was significantly prolonged in the nicardipine group throughout the reperfusion period. CONCLUSIONS: Intracoronary nicardipine enhances the recovery of regional contractile function but prolongs myocardial relaxation in the canine model of myocardial stunning.
Animals
;
Calcium
;
Catheters
;
Coronary Vessels
;
Dogs*
;
Flowmeters
;
Myocardial Ischemia
;
Myocardial Stunning*
;
Nicardipine*
;
Relaxation
;
Reperfusion
;
Stroke
9.Effectiveness of Nicardipine for Blood Pressure Control in Patients with Subarachnoid Hemorrhage.
Sang Yong KIM ; Seong Min KIM ; Moon Sun PARK ; Han Kyu KIM ; Ki Seok PARK ; Seong Young CHUNG
Journal of Cerebrovascular and Endovascular Neurosurgery 2012;14(2):84-89
OBJECTIVE: The purpose of the study is to determine the effectiveness and safety of nicardipine infusion for controlling blood pressure in patients with subarachnoid hemorrhage (SAH). METHODS: We prospectively evaluated 52 patients with SAH and treated with nicardipine infusion for blood pressure control in a 29 months period. The mean blood pressure of pre-injection, bolus injection and continuous injection period were compared. This study evaluated the effectiveness of nicardipine for each Fisher grade, for different dose of continuous nicardipine infusion, and for the subgroups of systolic blood pressure. RESULTS: The blood pressure measurement showed that the mean systolic blood pressure / diastolic blood pressure (SBP/DBP) in continuous injection period (120.9/63.0 mmHg) was significantly lower than pre-injection period (145.6/80.3 mmHg) and bolus injection period (134.2/71.3 mmHg), and these were statistically significant (p < 0.001). In each subgroups of Fisher grade and different dose, SBP/DBP also decreased after the use of nicardipine. These were statistically significant (p < 0.05), but there was no significant difference in effectiveness between subgroups (p > 0.05). Furthermore, controlling blood pressure was more effective when injecting higher dose of nicardipine in higher SBP group rather than injecting lower dose in lower SBP group, and it also was statistically significant (p < 0.05). During the infusion, hypotension and cardiogenic problems were transiently combined in five cases. However, patients recovered without any complications. CONCLUSION: Nicardipine is an effective and safe agent for controlling acutely elevated blood pressure after SAH. A more systemic study with larger patients population will provide significant results and will bring solid evidence on effectiveness of nicardipine in SAH.
Aneurysm
;
Blood Pressure
;
Humans
;
Hypertension
;
Hypotension
;
Nicardipine
;
Prospective Studies
;
Subarachnoid Hemorrhage
10.Effects of a Combination of Nicardipine and Alfentanil on Hemodynamic Response after Endotracheal Intubation.
Chang Mo KIM ; Sung Tae JEONG ; Seok Jai KIM ; Hong Beom BAE ; Jeong Il CHOI ; Seong Wook JEONG ; Sung Su CHUNG ; Kyung Yeon YOO ; Chang Young JEONG ; Myung Ha YOON
Korean Journal of Anesthesiology 2005;48(6):587-591
BACKGROUND: The present study was designed to examine the effect of a combination of nicardipine and low dose alfentanil on hemodynamic response following endotracheal intubation. METHODS: Thirty patients (20-65 yr) were assigned randomly to receive nicardipine (N: 20microgram/kg) or a combination of nicardipine and low dose of alfentanil (NA: nicardipine 10microgram/kg and alfentanil 5microgram/kg). Systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were measured at 1, 2 min after anesthetic induction, and every minute for 5 min after intubation. RESULTS: The magnitude of increases in SBP and DBP were non-significantly smaller in the NA group than in the N group, and increase in HR were significantly lower in the NA group. CONCLUSIONS: These results indicate that the nicardipine with alfentanil combination was more effective than nicardipine alone at attenuating blood pressure and heart rate increases following intubation.
Alfentanil*
;
Blood Pressure
;
Heart Rate
;
Hemodynamics*
;
Humans
;
Intubation
;
Intubation, Intratracheal*
;
Nicardipine*