Objective To analyze the clinical characteristics and treatment methods of recurrence hand,foot and mouth disease (HFMD).Methods The clinical data of 436 HFMD patients were retrospectively analyzed.The characteristics of clinical manifestations,laboratory tests were analyzed.Results There were a total of 211 patients,accounting for 48.4％,the recurrence age was 2 to 5 years old.All relapsed patients rash appeared in the hand,foot and mouth or buttocks,there were 104 cases of rash appeared in elbow and knee,9 cases appeared in the torso.The recurrence patients proned to occur respiratory system,digestive system,cardiovascular system and nervous system complications.Respiratory complications were the most common,accounting for about 76.4％,followed by the digestive system,accounting for 18.5％.The distribution of relapse in children with time to recurrence and recurrence in-terval analysis found mainly in April to June,a total of 251 patients,the total relapse proportion was 57.6％ ;time in-terval was more common between 3 months to 12 months,a total of 326 cases of recurrence,accounting for 74.8％.Conclusion Clinical manifestations are not typical in recurrence HFMD patients,most are ordinary,less critically illpatients,it is easy to merge the respiratory system,digestive system complications.Early detection and diagnosis is the key to the treatment.

OBJECTIVETo investigate the features of oral lesions in patients with human immunodeficiency virus infection/acquired immunodeficiency syndrome (HIV/AIDS).

METHODSA total of 127 HIV-seropositive patients were interviewed for health information and examined for their HIV-related oral lesions according to the EC Clearing House Criteria on Oral Problems related to HIV-Infection (1992). The examinations were conducted by dental specialist and HIV specialist. The CD4 T cell count in peripheral blood of the patients was tested by flow cytometry. The patients were divided into HIV- infected group (42) and AIDS group (85) according to CDC Classification System for HIV- Infected Adults and Adolescents (revised in 1993). Chi-square test was used to test the relationship between systemic disease and oral lesions, and the difference of the prevalence of oral lesions between the two groups.

RESULTSAmong the 127 patients, oral candidiasis (51/127), oral hairy leukoplakia (24/127) were common oral manifestation. There was no relationship between the oral manifestation and systemic disease (P = 0.397). The occurrence of oral lesions and oral candidiasis was significantly different between the two groups (χ² = 7.684, P = 0.006; χ² = 14.410, P < 0.001). The CD4 count was related to the prevalence of oral lesions (P = 0.006) and oral candidasis (P = 0.003).

CONCLUSIONSMost oral lesions appeared before the appearance of systemic disease. Oral candidiasis and oral hairy leukoplakia were the most common lesions.Oral lesions had no relationship with systemic disease but could be still an indicator for disease progress.

Acquired Immunodeficiency Syndrome ; complications ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes ; Candidiasis, Oral ; epidemiology ; China ; epidemiology ; HIV Infections ; Humans ; Leukoplakia, Hairy ; Mouth Diseases ; complications ; epidemiology ; Prevalence