Objective : To investigate the willingness to receive HIV testing in primary health service institutions (PHSIs) among young students in Wuhan City, so as to provide the evidence for improving the detection of HIV testing among young students. Methods: Fifteen PHSIs were sampled using a stratified random sampling method in 14 districts of Wuhan City, and school students at ages of 15 to 24 years were sampled from each district using a convenience sampling method. Participants' demographics, awareness of AIDS-related knowledge, HIV testing and willingness to receive HIV testing were collected using questionnaires, and factors affecting the willingness to receive HIV testing in PHSIs were identified among school students using a multivariable logistic regression model. Results : A total of 301 questionnaires were allocated, and 299 valid questionnaires were recovered, with an effective recovery rate of 99.34%. The respondents included 143 men (47.83%) and 156 women (52.17%), and had a mean age of (19.36±2.40) years; there were 223 respondents with an educational level of diploma and above (74.58%). The awareness of AIDS-related knowledge was 71.57% among the respondents, and 144 respondents had received AIDS-related health education in PHSIs (48.16%). There were 34 respondents that had received HIV testing (11.37%) and 203 respondents that were willing to receive HIV testing in PHSIs (67.89%). The respondents that were unwilling to receive HIV testing in PHSIs were mainly attributed to considering to be unlikely to get HIV infections (82.29%). Multivariable logistic regression analysis showed that school students who knew AIDS-related knowledge (OR=2.797, 95%CI: 1.583-4.941), knew free HIV counseling and testing services in PHSIs (OR=2.070, 95%CI: 1.123-3.814), and had received AIDS-related health education in PHSIs (OR=2.814, 95%CI: 1.573-5.032) were more willing to receive HIV testing in PHSIs. Conclusions There were 67.89% of school students that were willing to receive HIV testing in PHSIs in Wuhan City, and the willingness to receive HIV testing was correlated with the awareness of risk of HIV infections, and awareness and experience of AIDS control services in PHSIs.

Objective To analyze the survival time and influencing factors of HIV Infectors/AIDS patients in Wuhan from 1994-2022 and provide evidence for future prevention and control strategies.Methods Data on HIV/AIDS epidemiology and antiviral treatment were collected from 1994 to 2022 by the national HIV/AIDS Comprehensive Prevention and Control Data In-formation System.The life table method and Cox proportional hazard regression model were used to analyze survival time and its influencing factors.Results A total of 8954 patients with HIV/AIDS were followed up for 47245.4 person-years,with 1078 deaths from all causes,and the median survival time was 22.3 years.The survival rates at 1,5,10,15,and 20 years were 92.9％,88.5％,83.5％,78.7％,and 73.8％,respectively.The results of the Cox proportional hazard regression model analysis revealed that untreated,older age,unemployed,male,low literacy,native,heterosexual and injection drug transmission,being founcl by medical institution examination,and lower CD4 baseline levels were risk factors for HIV/AIDS patient survival time(untreated vs.treated,HR=13.979,95％CI:11.883-16.446;without stable occupations vs.stable occupations:HR=1.140,95％CI:1.004-1.295;locally registered residence vs.mobile patients:HR=1.682,95％CI:1.415-2.000;medical institution testing findings vs.VCT:HR=1.823,95％CI:1.421-2.339).Conclusion For risk factors such as being 50 years old and a-bove,being unemployed,having a low level of literacy,being detected by medical institutions and having a low CD4 baseline lev-el,we should improve the public's scientific understanding of HIV/AIDS through publicity and education and promote early de-tection and treatment through medical and prevention cooperation and social organization participation.Making full use of healthy big data of HIV/AIDS patients,forming multi-dimensional full-life cycle health files,providing accurate medical care for different individuals,including psychological intervention,and extending life time and improving quality of life are directions for future efforts.

Objective:To investigate the relationship between urate deposition on ultrasound and coronary artery calcification score in maintenance hemodialysis (MHD) patients.Methods:A total of 100 stable MHD patients undergoing hemodialysis for at least one year were enrolled in this study. All the patients had clinical and ultrasound examination at both knees, ankles and first metatarsophalangeal joints. Subgroup analysis was done depending on whether double contour sign (DCS) or tophus was found on ultrasound. The volume of coronary artery calcification (CAC) score were determined by a 64-slice CT. Main statistical analysis methods were t test, chi-square test, Spearman correlation and logistic regression model. Results:Among these 100 patients, DCS was found in 35 (35%) patients and tophus was found in 21 (21%) patients. The serum uric acid level, serum phosphate (P), parathyroid hormone (PTH), C-reactive protein (CRP) and incidence of CAC, CAC score of the DCS positive group [(629±61) μmol/L, (2.4±0.8) mmol/L, (658±56) pg/ml, (9.5±2.1) mg/L, 83%(29/35), (276±37), n=35] was significantly higher than the DCS negative group [(569±68) μmol/L, (2.0±0.6) mmol/L, (536±49) pg/ml, (7.9±3.1) mg/L, 59% (38/65), (219±42), n=65] ( t=4.322 6, P<0.01; t=2.712 6, P<0.01; t=11.293 1, P<0.01; t=2.700 3, P<0.01; t=5.070 1, P=0.024 3; t=6.827 6, P<0.01). The serum uric acid level was positively correlated with urate deposition on ultrasound ( r=0.317, P<0.05), which was positively correlated with CAC score ( r=0.302, P<0.05). The serum uric acid level, urate deposition on ultrasound and CAC score were all positively correlated with CRP ( r=0.298, P<0.05; r=0.345 , P<0.05; r=0.336, P<0.05) . Multivariate logistic regression analysis showed that the serum uric acid level and CRP were independent risk factors for positive DCS in MHD patients [ OR=3.040, 95% CI (1.507, 6.133); OR=3.438, 95% CI(1.822,6.489)]. Positive DCS and CRP were independent risk factors for CAC [ OR=3.504, 95% CI (1.414, 9.684); OR=3.885, 95% CI(1.364, 11.063)]. Conclusion:In MHD patients, positive DCS is related with high serum uric acid level and CRP. Positive DCS and CRP are independent risk factors for CAC.

Objective:To evaluate the reliability and validity of the Reward Probability Index-Chinese version (C-RPI) among individuals with opioid dependence.Methods:A total of 160 individuals with opioid dependence were recruited from the methadone maintenance treatment(MMT) programs in Wuhan.The C-RPI was used in the investigation, and items/exploratory factors and confirmatory factors were adopted to analyze with IBM SPSS 22.0 and AMOS 24.0, respectively.Results:The correlation between each item and the total score of the scale was 0.325-0.657 (all P<0.01) and the item discrimination of the scale was good.Exploratory factor analysis extracted two factors, including reward probability and environmental suppressors, and a load of each item on its factor ranged from 0.519 to 0.744.The fitting indexes of confirmatory factor analysis were as follows: χ 2/ df=1.623, RMR=0.030, RMSEA=0.063, IFI=0.902, TLI=0.885, CFI =0.900.The internal consistency coefficient (Cronbach's α) of the C-RPI was 0.800; and there was no ceiling/floor effect on each dimension and total scale. Conclusion:The classification of dimensions for the C-RPI is reasonable, and the scale has good reliability and validity to measure the ability to obtain environmental rewards for individuals with opioid dependence.