1. Angelica sinensis polysaccharide promotes stress erythropoiesis in mice caused by 5-FU
Bi-Yao WANG ; Han-Xian-Zhi XIAO ; Yi-Lin NIU ; Nian-Ci SUN ; Zi-Ling WANG ; Ya-Ping WANG ; Lu WANG ; Bi-Yao WANG ; Han-Xian-Zhi XIAO ; Yi-Lin NIU ; Nian-Ci SUN ; Zi-Ling WANG ; Ya-Ping WANG ; Lu WANG
Chinese Pharmacological Bulletin 2023;39(10):1949-1956
Aim To investigate the effects of angelica sinensis polysaccharide (ASP) antagonizing 5-fluorou-raeil (5-FU) on spleen stress erythropoiesis in mice and its related mechanism. Methods C57BL/6J mice aged 6-8 weeks were randomly divided into control group, ASP group, 5-FU group and ASP + 5-FU group. The mouse body weight during the modeling pe-riod was recorded, and peripheral blood routine and the number of mononuclear cells in the bone marrow of femur were measured. Histopathology of spleen was de-tected, also the index and cellularity of spleen were analyzed. BFU-E of spleen mononuclear cells was counted. The number of F4/80
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